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  4. Recombinant Mouse Probable G-protein coupled receptor 37 (Gpr37)

Recombinant Mouse Probable G-protein coupled receptor 37 (Gpr37)

  • 货号：
    CSB-CF870763MO
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
  • Uniprot No.：
  • 别名：
    Gpr37; Prosaposin receptor GPR37; G-protein coupled receptor 37
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    27-600
  • 氨基酸序列
    ALSFVPEPRNGTCLGESCSPLIQRRSRDARGPGNSAKDALRVHVPREKLEAEVRGATSWD LPPPRGGDTGVIEEAAAAGPLGPPTKPPSAWRWKSAQGKEPSGHLRRRDPTDPQLFFPTS EGGEMSSKRDGIPQSRQEHSVKTEPRDLFYWPRRTGQLQDSQHRPSAVHEGRTLAPPGRA LPQNGSADDWVPDQGGPRRGNTTRRVRLKNPFYPLTQESYGAYAVMCLSVVIFGTGIIGN LAVMCIVCHNYYMRSISNSLLANLAFWDFLIIFFCLPLVIFHELTKKWLLEDFSCKIVPY IEVASLGVTTFTLCALCIDRFRAATNVQMYYEMIENCSSTTAKLAVIWVGALLLALPEVV LRQLSKEDLGFSGQAPAERCVIKISPDLPDTIYVLALTYDGARLWWYFGCYFCLPTLFTI TCSLVTARKIRKAEKASTRGNKRQIHLESQMNCTVVALTILYGFCIIPENICNIVTAYMA TGVSQQTMDLLNIISQFLLFFKSCVTPVLLFCLCRPFSRAFMECCCCCCEECIQKSSTVT SDDNDNEYTTELELSPFSTIRREMSTFASVGTHC
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Receptor for the neuroprotective and glioprotective factor prosaposin. Ligand binding induces endocytosis, followed by an ERK phosphorylation cascade.
  • 基因功能参考文献：
    1. This studies revealed that Gpr37(-)(/)(-) mice exhibit dramatically increased loss of myelin in response to cuprizone. PMID: 28642167
    2. We conclude that GPR37 is crucial for cellular protein quality control during Wnt signaling. PMID: 28341812
    3. Data suggest that GPR37 regulates central nervous system myelination by controlling the transition from early-differentiated to mature oligodendrocytes. PMID: 26961174
    4. Knocking-out GPR37 triggers anxiolytic-like effects and regulates hippocampal A2AR-mediated signaling. PMID: 25824528
    5. These data show functional association between GPR37, prosaposin, and GM1 ganglioside in the plasma membrane. PMID: 24371137
    6. GPR37 knockout mice show age and sex specific improvements in olfaction, increased anxiety and depression-like behaviors. PMID: 23574697
    7. Upregulation of Pael-R in the substantia nigra pars compacta of mice by retrograde infection induced endoplasmic reticulum (ER) stress leads to death of dopaminergic neurons. PMID: 17116640
    8. GPR37 associates with the dopamine transporter to modulate dopamine uptake and behavioral responses to dopaminergic drugs. PMID: 17519329
    9. Data show that GPR37 overexpression can induce cellular autophagy, which may prevent the selective degeneration of GPR37-expressing neurons, as reported for Parkinson's and related neurodegenerative diseases. PMID: 19218498
    10. Macroautophagy of the GPR37 orphan receptor and Parkinson disease-associated neurodegeneration PMID: 19398891

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 1 family
  • 数据库链接：

    KEGG: mmu:14763

    STRING: 10090.ENSMUSP00000052185

    UniGene: Mm.409670