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  4. Recombinant Mouse Potassium voltage-gated channel subfamily A member 5 (Kcna5)

Recombinant Mouse Potassium voltage-gated channel subfamily A member 5 (Kcna5)

  • 中文名称：
    小鼠Kcna5重组蛋白
  • 货号：
    CSB-CF726758MO
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
    Kcna5
  • Uniprot No.：
  • 别名：
    Kcna5; Potassium voltage-gated channel subfamily A member 5; Voltage-gated potassium channel subunit Kv1.5; KV1-5
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-602
  • 氨基酸序列
    MEISLVPMENGSAMTLRGGGEAGASCVQSPRGECGCPPTAGLNNQSKETSPRRRATHEDA GQGGRPLPPMPQELPQPRRPSAEDEEGEGDPGLGTVEEDQAPQDSGSLHHQRVLINISGL RFETQLGTLAQFPNTLLGDPVKRLRYFDPLRNEYFFDRNRPSFDGILYYYQSGGRLRRPV NVSLDVFADEIRFYQLGDEAMERFREDEGFIKEEEKPLPRNEFQRQVWLIFEYPESSGSA RAIAIVSVLVILISIITFCLETLPEFRDERELLRHPPVPPQPPAPAPGANGSGSGVLSSG PTVAPLLPRTLADPFFIVETTCVIWFTFELLVRFFACPSKAEFSRNIMNIIDIVAIFPYF ITLGTELAEQQPGGGGQNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGKTLQASM RELGLLIFFLFIGVILFSSAVYFAEADNQGSHFSSIPDAFWWAVVTMTTVGYGDMRPITV GGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETDHEEQAALKEEQGIQRRESGLDTG GQRKVSCSKASFCKTGGPLESTDSIRRGSCPLEKCHLKAKSNVDLRRSLYALCLDTSRET DL
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane. Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA5, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel. Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation. Homotetrameric channels display rapid activation and slow inactivation. May play a role in regulating the secretion of insulin in normal pancreatic islets.
  • 基因功能参考文献：
    1. KV1.5 channels predominantly associate with KVbeta1 and KVbeta2 proteins and that KVbeta2 performs a chaperone function for KV1.5 channels in arterial myocytes, thereby facilitating Kv1alpha trafficking and membrane localization. PMID: 28342889
    2. The findings uncover detailed molecular mechanisms underpinning a channelopathy-linked form of atrial fibrillation and emphasize the inevitability of considering extracardiac mechanisms in genetic arrhythmia syndromes. PMID: 26985008
    3. Silencing of Kv1.5 improved endothelium-dependent vasodilatation in thoracic aorta from type 2 diabetes mice. PMID: 26764232
    4. Intracellular urate taken up by UATs enhanced Kv1.5 protein expression and function in HL-1 atrial myocytes. PMID: 26477273
    5. KV1.5, a DPO-1-sensitive KDR channel, plays a major role in determining microvascular tone and the response to vasoconstrictors and vasodilators. PMID: 25808400
    6. Kv1.5 channels in vascular smooth muscle play a critical role in coupling myocardial blood flow to cardiac metabolism. PMID: 26224794
    7. the Kv1.5 subunit has a role in electrical remodeling of preoptic GABAergic neurons PMID: 24797243
    8. MYO5A and MYO5B control functionally distinct steps in the surface trafficking of Kv1.5. PMID: 24508725
    9. e-LXA4 promoted a modest upregulation of Kv1.5 mRNA that was suppressed by LPS or IL-4/IL-13. PMID: 24249731
    10. The combined down-regulation of Kv4.2, Kv1.5 and KChIP2 prior to the onset of HF may play an important role in the premature sudden death in this DCM model. PMID: 22514734
    11. cortactin was required for N-cadherin-mediated enhancement of Kv1.5 channel activity PMID: 21507952
    12. Data confirm KCNA5 in left/right atria & indicate functional interaction of KCNA5 (ultra rapid) & KCNH2 (rapid). Action potentials are longer in right atrial myocytes than in left; this is due partly to smaller amplitude of KCNA5 in right atrium. PMID: 20826138
    13. KChIP2 contributes to the formation of functional mouse ventricular Kv1.5 channels PMID: 15878168
    14. hyperthyroidism resulted in more significant action potential shortening and greater delayed rectifier K(+) current increases in the right vs. the left atrium, which can contribute to the propensity for atrial arrhythmia in hyperthyroid heart PMID: 15894573
    15. Our results show that Kcna5 promoter activity in vascular smooth muscle is critically dependent on Sp1 regulation via CACCC box motifs and identify mechanisms that potentially influence the expression of K(V)1.5 channel expression. PMID: 17660393
    16. Kv1.5 has a role in Rab-GTPase-dependent endocytic recycling in atrial myocytes PMID: 17673464
    17. These results suggest that the inhibition of K(v) channel expression and rise in [Ca(2+)](i) during chronic hypoxia may be the result of HIF-1-dependent induction of ET-1. PMID: 18065659
    18. Antiarrhythmic drug-induced internalization of the atrial-specific k+ channel kv1.5. PMID: 19443837
    19. Downregulation of Kv4.3 and Kv1.5 transcripts by estrogen are one mechanism defining gender-related differences in mouse ventricular repolarization. PMID: 19608983

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Potassium channel family, A (Shaker) (TC 1.A.1.2) subfamily, Kv1.5/KCNA5 sub-subfamily
  • 组织特异性：
    Highly expressed in heart and moderately in brain. Low levels in thymus, skeletal muscle and spleen. Not expressed in liver, lung or kidney.
  • 数据库链接：

    KEGG: mmu:16493

    STRING: 10090.ENSMUSP00000055673

    UniGene: Mm.222831