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  4. Recombinant Mouse Neuromedin-B receptor (Nmbr)

Recombinant Mouse Neuromedin-B receptor (Nmbr)

  • 货号：
    CSB-CF015881MO
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
  • Uniprot No.：
  • 别名：
    Nmbr; Neuromedin-B receptor; NMB-R; Neuromedin-B-preferring bombesin receptor
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-390
  • 氨基酸序列
    MPPRSLSNLSFPTEANESELVPEVWEKDFLPDSDGTTAELVIRCVIPSLYLIIISVGLLG NIMLVKIFLTNSAMRNVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWVFGKLGCKLIP AIQLTSVGVSVFTLTALSADRYRAIVNPMDMQTSGVLLWTSLKAVGIWVVSVLLAVPEAV FSEVARIGSLDNSSFTACIPYPQTDELHPKIHSVLIFLVYFLIPLVIISIYYYHIAKTLI KSAHNLPGEYNEHTKKQMETRKRLAKIVLVFVGCFVFCWFPNHVLYLYRSFNYKEIDPSL GHMIVTLVARVLSFSNSCVNPFALYLLSESFRKHFNSQLCCGRKSYPERSTSYLLSSSAV RMTSLKSNTKNVVTNSVLLNGHSTKQEIAL
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Receptor for neuromedin-B.
  • 基因功能参考文献：
    1. Neuromedin B expression identifies retrotrapezoid nucleus neurons in the mouse. PMID: 29066557
    2. NMB or NMBR silencing inhibited M-CSF/c-Fms-mediated downstream signaling pathways like activation of ERK and Akt and induction of D-type cyclins, cyclin D1 and D2. PMID: 28780306
    3. mice with deletion of NB receptor have lower insulinemia, especially in response to oral glucose, and females also exhibited a better glucose tolerance, suggesting the involvement of neuromedin b and its receptor in regulation of insulin secretion induced by incretins, and also, in insulin sensitivity. PMID: 27756093
    4. ablating NMB receptor-expressing neurons eliminated basal and hypoxia-induced sighing, but left breathing otherwise intact initially PMID: 26855425
    5. The neuromedin B pathways are importantly involved in secretory pathways of TSH and revealed its participation in the in vivo regulation of gene expression of TSH beta-subunit and pituitary MCT8 and Thrb and hypothalamic TRH and type 2 deiodinase. PMID: 25454367
    6. Together, we define the respective function of NMBR and GRPR in itch transmission, and reveal an unexpected relationship not only between the two receptors but also between the two populations of interneurons in itch signaling. PMID: 25209280
    7. spinal GRPr and NMBr independently drive itch neurotransmission in mice. PMID: 23826298
    8. Results implicate that NMB is involved in cartilage development, either in an autocrine or paracrine manner. PMID: 22652580
    9. The mRNA and protein expressions of NMBR reach a peak at the onset of labor. PMID: 19587437
    10. disruption of the neuromedin B receptor pathway did not change body weight homeostasis in female mice fed a normolipid diet PMID: 20211980
    11. NMB-R-deficient mice exhibited decreased behavior in both the L-D box and elevated plus maze tests. PMID: 11803457
    12. 5-HT expression in the dorsal raphe (DR)nucleus is elevated in NMB-R-deficient mice. NMB/NMB-R may modulate 5-HT neuronal activity by affecting DR function. PMID: 12031854
    13. Impaired memory in stressed neuromedin B receptor-deficient mice not consequence of changes in activity, anxiety, or pain response. NMB/NMB-R pathway may have role in regulating stress response via neural system controlling learning and memory. PMID: 12576129
    14. NMBR and BRS-3 genes were expressed from embryonic days 13-16 and on multiple postnatal days for lungs PMID: 12959933
    15. Selectivity of NMBR for neuromedin B over the gastrin-releasing peptide receptor depends primarily on differences in amino acids in the third extracellular domains of the receptors and in the adjacent upper fifth transmembrane region of the two receptors. PMID: 19628633

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 1 family
  • 数据库链接：

    KEGG: mmu:18101

    STRING: 10090.ENSMUSP00000020015

    UniGene: Mm.487342