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  4. Recombinant Mouse Melanocyte-stimulating hormone receptor (Mc1r)

Recombinant Mouse Melanocyte-stimulating hormone receptor (Mc1r)

  • 中文名称：
    小鼠Mc1r重组蛋白
  • 货号：
    CSB-CF013558MO
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
  • Uniprot No.：
  • 别名：
    Mc1r; Msh-r; Melanocyte-stimulating hormone receptor; MSH-R; Melanocortin receptor 1; MC1-R
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-315
  • 氨基酸序列
    MSTQEPQKSLLGSLNSNATSHLGLATNQSEPWCLYVSIPDGLFLSLGLVSLVENVLVVIA ITKNRNLHSPMYYFICCLALSDLMVSVSIVLETTIILLLEAGILVARVALVQQLDNLIDV LICGSMVSSLCFLGIIAIDRYISIFYALRYHSIVTLPRARRAVVGIWMVSIVSSTLFITY YKHTAVLLCLVTFFLAMLALMAILYAHMFTRACQHAQGIAQLHKRRRSIRQGFCLKGAAT LTILLGIFFLCWGPFFLHLLLIVLCPQHPTCSCIFKNFNLFLLLIVLSSTVDPLIYAFRS QELRMTLKEVLLCSW
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Mediates melanogenesis, the production of eumelanin (black/brown) and phaeomelanin (red/yellow), via regulation of cAMP signaling in melanocytes.
  • 基因功能参考文献：
    1. These data clearly show a new and hitherto unsuspected role for MC1R in noncutaneous solid tissues before birth. PMID: 29316344
    2. Collectively, our findings suggest that melanocortin therapy confers a proteinuria reducing and podoprotective effect in proteinuric glomerulopathies via MC1R-independent mechanisms. PMID: 27270328
    3. results highlight a central role for MC1R palmitoylation in pigmentation and protection against melanoma PMID: 28869973
    4. We conclude that MC1R plays an important role in regulating melanoma growth and morphology PMID: 27028866
    5. Activation of Mc1r prevents cholesterol uptake and confers protection against macrophage foam cell formation. PMID: 28450348
    6. MC1-mediated effects were reduced, and MC3 anti-inflammatory circuits predominated. Mice bearing a nonfunctional MC1 displayed a transient exacerbation of neutrophil recruitment after global I/R, which diminished by 2 hours. PMID: 26112010
    7. MR importantly contributes to diabetes-associated vascular dysfunction by inducing oxidative stress and by increasing the activity of redox-sensitive proteins PMID: 25967696
    8. MC1 has an endogenous regulatory function in collagen synthesis and controls the extent of fibrotic stress responses of the skin. PMID: 24698097
    9. A melanin-independent interaction between Mc1r and Met signaling pathways is required for hepatocyte growth factor-dependent melanoma. PMID: 24975581
    10. In summary, we have identified a new alpha-MSH-MC1R physiologic pathway that reduces HO-induced RPE cell damage, and might minimize the risk of developing AMD. PMID: 24316214
    11. Absence of Mc1r does not impair the inflammatory response to UV radiation or the generation of immunosuppression. PMID: 23489427
    12. MC1R decrease the inflammation in vitro and vivo, and might be part of a signaling pathway in inflammatory diseases. PMID: 23090482
    13. Melanocortin receptors 1 and 5 might mediate inhibitory effects of alpha-melanocyte-stimulating hormone on antigen-induced chronic allergic skin inflammation in IgE transgenic mice. PMID: 22437312
    14. MC1R regulates melanoma cell migration via inhibition of syndecan-2 expression. PMID: 22493442
    15. Spatiotemporal localization of MC1R and alpha-MSH in cutaneous wounds warrants future investigation into the role of MC1R/alpha-MSH signaling in the inflammatory and fibroproliferative responses to cutaneous injury. PMID: 21378282
    16. Data show RNA interference that targets Ube3a in P19 cells caused downregulation of Mc1r and Nr4a2, whereas overexpression of Ube3a results in the upregulation of Mc1r and Nr4a2. PMID: 20571502
    17. MC1R contributes to pain of inflammatory origin. PMID: 20856883
    18. MC1R protects by a combination of pigmentary and non-pigmentary effects in vivo and when MC1R function is compromised the melanin type in skin is still protective against UVR PMID: 20237490
    19. The pigmentation of atopic dermatitis is related to increased levels of alpha-MSH, MC1R (in the skin) and MC3R (in intestines). PMID: 19889022
    20. The human receptor efficiently rescued mouse Mc1r deficiency and appeared to be completely resistant to the effect of agouti, suggesting agouti protein may play a role in human pigmentary variation. PMID: 11689486
    21. Antagonist and agonist activities of the mouse agouti protein fragment (91-131) at the melanocortin-1 receptor. PMID: 11693171
    22. the function of the MC1 and MC4 receptors can be positively modulated by metal ions acting both as partial agonists and as potentiators for other agonists PMID: 12244039
    23. the melanocortin-1 receptor (Mc1r) gene mediates kappa-opioid analgesia in female mice only PMID: 12663858
    24. Regulation of melanocortin 1 receptor mRNA and protein levels. PMID: 14500544
    25. there was a significant difference in anesthetic requirements between mice with homozygous melanocortin 1 receptor and control heterozygous mice PMID: 15277941
    26. UV-induced expression of POMC and MC1R is dependent on the p-38-activated upstream stimulating factor-1 PMID: 15358786
    27. The The expression of the Melanocortin Receptor 1 genes in the epidermis and dermis of the dorsal skin was surveyed from 13 d old embryos to 5.5 d old neonates. PMID: 15541020
    28. Melanocortin 1 receptor signaling is regulated by GRK2 and GRK6, which may be important determinants of skin pigmentation. PMID: 15650023
    29. C57BL/6-Mc1r(e/e) mutant mice and human redheads--both with non-functional MC1Rs--display reduced sensitivity to noxious stimuli and increased analgesic responsiveness to the mu-opioid selective morphine metabolite, M6G. PMID: 15994880
    30. ultraviolet light potently induces expression of MSH in keratinocytes, but fails to stimulate pigmentation in the absence of functional MC1R in red/blonde-haired Mc1r(e/e) mice PMID: 16988713
    31. These findings offer insights into the transcriptional nature of the response to ultraviolet rays (UV) in the skin and provide a molecular framework for the mechanisms by which melanocytes and the Mc1r independently afford protection against UV radiation. PMID: 17222061
    32. Results suggest that the Mc1r(e) mutation affects the proliferation and differentiation of melanocytes and l-tyrosine rescues the reduced proliferative and differentiative activities. PMID: 17532540
    33. two genes interact epistatically: the phenotypic effects of Mc1r are visible only in genetic backgrounds containing the derived Agouti allele PMID: 17696646
    34. These data identify the NR4A receptor family as potential mediators of an MC1R-coordinated DNA damage response to ultraviolet rays exposure in melanocytic cells. PMID: 18292087
    35. These findings demonstrate that alpha-MSH suppression of lipopolysaccharide-induced inflammatory activity in macrophages requires expression of MC1r. PMID: 18388300
    36. molecular effects elicited by MC1R ligands that may function during development and may affect skin cancer risk PMID: 19174519

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 1 family
  • 数据库链接：

    KEGG: mmu:17199

    STRING: 10090.ENSMUSP00000095929

    UniGene: Mm.324942