Your Good Partner in Biology Research

  1. 首页
  2. 蛋白
  3. 跨膜蛋白
  4. Recombinant Mouse Mas-related G-protein coupled receptor member X1 (Mrgprx1)

Recombinant Mouse Mas-related G-protein coupled receptor member X1 (Mrgprx1)

  • 货号：
    CSB-CF817224MO
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
  • Uniprot No.：
  • 别名：
    Mrgprx1; Mrgc11; Mrgprc11; Mas-related G-protein coupled receptor member X1; Mas-related G-protein coupled receptor member C11; Sensory neuron-specific G-protein coupled receptor 1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-322
  • 氨基酸序列
    MDPTISSHDTESTPLNETGHPNCTPILTLSFLVLITTLVGLAGNTIVLWLLGFRMRRKAI SVYILNLALADSFFLCCHFIDSLLRIIDFYGLYAHKLSKDILGNAAIIPYISGLSILSAI STERCLCVLWPIWYHCHRPRNMSAIICALIWVLSFLMGILDWFSGFLGETHHHLWKNVDF IITAFLIFLFMLLSGSSLALLLRILCGPRRKPLSRLYVTIALTVMVYLICGLPLGLYLFL LYWFGVHLHYPFCHIYQVTAVLSCVNSSANPIIYFLVGSFRQHRKHRSLKRVLKRALEDT PEEDEYTDSHLHKTTEISESRY
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Orphan receptor activated by neuropeptides terminating in Arg-Phe or Arg-Phe-amide. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. May regulate the function of nociceptive neurons by modulation of pain perception.
  • 基因功能参考文献：
    1. SLIGRL-amide inhibits influenza A virus infection independently of MRGPRC11 and independently of capsaicin-sensitive, neuropeptide-releasing sensory nerves. PMID: 27215903
    2. Der p1 also induced the release of IL-6 from heterologous cells expressing MRGPRX1. In summary, activation of Mrgprs by the allergen Der p1 may contribute to inflammation. PMID: 28768771
    3. Cathepsin S activates MrgprC11 and evokes receptor-dependent scratching in mice. PMID: 26216096
    4. Results suggest that activation of MrgC11 may inhibit high-voltage-activated calcium current in mouse dorsal root ganglion neurons through a voltage-independent mechanism that involves activation of the phospholipase C, but not Galphai or Galphas, pathway PMID: 26022362
    5. Mouse bone marrow-derived mast cells express the MrgC11 receptor agonist, RF-amide precursor gene proneuropeptide FF. PMID: 18250432

    显示更多

    收起更多

  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 1 family, Mas subfamily
  • 组织特异性：
    Expressed in a subset of IB4-positive small diameter nociceptive dorsal root neurons.
  • 数据库链接：

    KEGG: mmu:404242

    STRING: 10090.ENSMUSP00000091954

    UniGene: Mm.354955