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  4. Recombinant Mouse Lysophosphatidic acid receptor 1 (Lpar1)

Recombinant Mouse Lysophosphatidic acid receptor 1 (Lpar1)

  • 货号：
    CSB-CF013047MO
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
  • Uniprot No.：
  • 别名：
    Lpar1; Edg2; Gpcr26; Lpa1; Vzg1; Lysophosphatidic acid receptor 1; LPA receptor 1; LPA-1; Lysophosphatidic acid receptor Edg-2; Rec1.3; VZG-1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-364
  • 氨基酸序列
    MAAASTSSPVISQPQFTAMNEQQCFYNESIAFFYNRSGKYLATEWNTVSKLVMGLGITVC VFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYFYLMFNTGPNTRRLTVST WLLRQGLIDTSLTASVANLLAIAIERHITVFRMQLHTRMSNRRVVVVIVVIWTMAIVMGA IPSVGWNCICDIDHCSNMAPLYSDSYLVFWAIFNLVTFVVMVVLYAHIFGYVRQRTMRMS RHSSGPRRNRDTMMSLLKTVVIVLGAFIVCWTPGLVLLLLDVCCPQCDVLAYEKFFLLLA EFNSAMNPIIYSYRDKEMSATFRQILCCQRNENPNGPTEGSDRSASSLNHTILAGVHSND HSVV
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Receptor for lysophosphatidic acid (LPA). Plays a role in the reorganization of the actin cytoskeleton, cell migration, differentiation and proliferation, and thereby contributes to the responses to tissue damage and infectious agents. Activates downstream signaling cascades via the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Signaling inhibits adenylyl cyclase activity and decreases cellular cAMP levels. Signaling triggers an increase of cytoplasmic Ca(2+) levels. Activates RALA; this leads to the activation of phospholipase C (PLC) and the formation of inositol 1,4,5-trisphosphate. Signaling mediates activation of down-stream MAP kinases. Contributes to the regulation of cell shape. Promotes Rho-dependent reorganization of the actin cytoskeleton in neuronal cells and neurite retraction. Promotes the activation of Rho and the formation of actin stress fibers. Promotes formation of lamellipodia at the leading edge of migrating cells via activation of RAC1. Through its function as lysophosphatidic acid receptor, plays a role in chemotaxis and cell migration, including responses to injury and wounding. Plays a role in triggering inflammation in response to bacterial lipopolysaccharide (LPS) via its interaction with CD14. Promotes cell proliferation in response to lysophosphatidic acid. Required for normal skeleton development. May play a role in osteoblast differentiation. Required for normal brain development. Required for normal proliferation, survival and maturation of newly formed neurons in the adult dentate gyrus. Plays a role in pain perception and in the initiation of neuropathic pain.
  • 基因功能参考文献：
    1. Study shows that lysophosphatidic acid (LPA) propagates post-injury schwann cell (SC) dedifferentiation through lysophosphatidic acid 1 signaling. These data indicate that LPA may be a critical factor that shifts SCs towards a post-injury phenotype and contributes to the onset of Wallerian degeneration. PMID: 29051083
    2. we demonstrate that LPA1/3 antagonism mildly reduced plasma LDL cholesterol levels. Therefore, pharmacological inhibition of LPA1/3 receptors may prove a promising approach to diminish atherosclerosis development. PMID: 27883026
    3. LPA receptor 1 signaling increased TGFbeta expression via GSK3beta phosphorylation and SREBP1 activation, contributing to the development of diabetic nephropathy. PMID: 28111010
    4. Our data suggest that LPAR signaling stimulates SS development by induction of IL-17 production via ROCK and p38 MAPK pathways. Thus, LPAR inhibition could be a possible therapeutic strategy for SS. PMID: 28460477
    5. Our results suggest that LPA-enhanced foam cell formation is mediated by LPA1/3 -AKT activation and subsequent SRBI expression. PMID: 28765047
    6. Lysophosphatidic acid-LPA1 signaling is critically required for septation during alveolarization. PMID: 27082727
    7. Data show that lysophosphatidic acid receptor 1 (LPA1)-green fluorescent proteins can be used to directly quantify the running-induced increase in precursor proliferation. PMID: 27050949
    8. Results suggest a relevant role for the Lysophosphatidic acid/Lysophosphatidic acid receptor 1 signaling system in alcoholism. In addition, the LPA1-null mice emerge as a new model for genetic vulnerability to excessive alcohol drinking PMID: 26700247
    9. Findings describe a functional role for lysophosphatidic acid 1 receptor in the regulation of oligodendrocyte differentiation and myelination in the central nervous system. PMID: 25226845
    10. Data show that lysophosphatidic acid (LPA) induces phosphorylation of trkA receptor (TrkA) through lysophosphatidic acid receptor 1 (LPA1) binding to TrkA PMID: 26597701
    11. LPA receptor has a role in bone loss in ovariectomized mice, but the favorable effect of its inhibition on bone remodeling is less general than hypothesized PMID: 24994065
    12. These findings suggest that tumor and stromal LPA receptors, in particular LPA1 and LPA5, play different roles in invasion and the seeding of metastasis PMID: 25158955
    13. LPA1 receptor is involved in emotional behaviors and in the anatomical integrity of the corticolimbic circuit, the deregulation of which may be a susceptibility factor for anxiety disorders. PMID: 23775489
    14. These results suggest that Ile325, Tyr85, and Leu87 within LPA1 are essential for LPA1 protein properly folding in the ER. PMID: 25025571
    15. These results suggest that LPA1 receptor-mediated amplification of spinal LPA production is required for the development of paclitaxel-induced neuropathic pain. PMID: 25411045
    16. these results demonstrate that LPA1 is essential for in vitro and in vivo osteoclast activities. PMID: 24429286
    17. Ultrastructural analyses of peripheral nerves in mouse null-mutants for LPA1 showed delayed schwann cell-to-axon segregation, polyaxonal myelination by single schwann cells, and thinner myelin sheaths. PMID: 24115248
    18. This study demonstrate a correlation between gene expression and cell birthdates. Lpar1 cells are preferentially generated on E11.5 and survive preferentially after the first postnatal week compared with other subplate neurons PMID: 22628460
    19. Lysophosphatidic acid receptor 1 is necessary for development of arthritis. PMID: 23666827
    20. LPA1 receptor signaling plays key roles in the development of central neuropathic pain following cerebral ischemia PMID: 23318243
    21. Galphaq-coupled Lpar1 regulates cell proliferation and migration by activating two distinct PLC-beta isozymes, PLC-beta1 and PLC-beta2, respectively. PMID: 23478264
    22. LPA(1) is involved in bone development by promoting osteogenesis. PMID: 22867754
    23. LPA(1)-null mice displayed a basal c-Fos hyperactivity in the hippocampus and in the medial prefrontal cortex, which was regulated differently by the two different memory tasks employed. PMID: 22537775
    24. findings suggest that LPA1 receptor may be necessary for a normal associative contextual learning associated to cocaine, probably through the modulation of hippocampal glutamatergic circuits. PMID: 21887497
    25. The ability of LPA-LPA(1) signaling to promote epithelial cell apoptosis and fibroblast resistance to apoptosis may therefore contribute to the capacity of this signaling pathway to regulate the development of pulmonary fibrosis after lung injury. PMID: 22021336
    26. the ATX-LPA-LPAR axis is a critical regulator of embryonic vascular development that is conserved in vertebrates PMID: 21971049
    27. These results suggest that LPA1 strongly influences bone development both qualitatively and quantitatively and that, in vivo, its absence results in decreased osteogenesis with no clear modification of osteoclasis. PMID: 21569876
    28. the absence of the LPA receptor aggravates the chronic stress-induced impairment to hippocampal neurogenesis and its dependent functions PMID: 21980482
    29. Lysophosphatidic acid receptor 1 modulates lipopolysaccharide-induced inflammation in alveolar epithelial cells and murine lungs. PMID: 21821728
    30. These results suggest defined pathways for signaling through the lysophosphatidic acid receptor 1 to promote lysophosphatidic acid-mediated myosin II activation and subsequent cell migration in 4T1 breast cancer cells. PMID: 21302283
    31. This study shows that CaMKII and related synaptic mechanisms at glutamatergic synapses are strongly dysregulated in LPA1 KO mice. PMID: 20942999
    32. These data identify stereotyped and selective hypoxia-induced cerebral cortical disruption requiring LPA(1) signaling. PMID: 21878565
    33. LPA1 receptor has a role in angiogenesis in tumor cells and xenografts PMID: 20708100
    34. These results suggest that lysophosphatidic acid, which is converted from lysophosphatidylcholine by ATX, activates LPA1 receptors and induces dorsal root demyelination following nerve injury, which causes neuropathic pain. PMID: 21062487
    35. LPA(1-3) are differentially expressed in the central nervous system and their expression is upregulated in response to injury. PMID: 20495828
    36. exploratory and emotional impairments did not account for the cognitive deficits that may be attributed to maLPA(1) nulls' hippocampal malfunction PMID: 20388543
    37. LPA(1) and LPA(3) (lysophosphatidic acid)receptors promote neointima formation through activation of CXCL12-mediated mobilization and recruitment of smooth muscle progenitor cells. PMID: 20360252
    38. lysophosphatidic acid receptor-1 has a role in diet-induced obesity PMID: 20358347
    39. We propose that the LPA(1) receptor may play a major role in both spatial memory and response to anxiety-like conditions. PMID: 19689455
    40. LPA stimulation promotes the interaction of the LPA(2) receptor with a focal adhesion molecule, TRIP6 PMID: 14688263
    41. A marked deficit in prepulse inhibition, changes in the levels of brain 5-HT and a craniofacial dysmorphism is seen in LPA1 receptor-deficient mice, defects resembling those found in psychiatric disease. PMID: 14697676
    42. LPA and angiotensin II were also capable of inducing LPA1 receptor phosphorylation, showing that LPA1 receptor can be subjected to homologous and heterologous desensitization PMID: 15369458
    43. LPA does not behave as a potent PPARgamma agonist in adipocytes but, conversely, inhibits PPARgamma expression and adipogenesis via LPA(1) receptor activation PMID: 15710620
    44. LPA(1) function in normal cortical development and suggest that the presence of genetic modifiers of LPA(1) influences cerebral cortical development PMID: 17656621
    45. LPA1 links pulmonary fibrosis to lung injury by mediating fibroblast recruitment and vascular leak PMID: 18066075
    46. distinct molecular mechanisms regulate agonist-dependent and PMA-dependent internalization of the LPA 1 receptor. PMID: 18089565
    47. The results demonstrated that in C9 cells estrogens modulate LPA(1) action through estrogen receptor alpha with the participation of protein kinase C alpha and phosphoinositide 3-kinase. PMID: 18166159
    48. A novel in vivo function for LPA signaling as a germ cell survival factor during spermatogenesis. PMID: 18448840
    49. Results support the operation of lysophosphatidic acid receptor (1) signaling pathways in normal proliferation, maturation and differentiation of neuronal precursors. PMID: 18708146
    50. a direct role for LPA receptor signaling in cell transformation and tumorigenesis in conjunction with c-Myc PMID: 18762810

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  • 亚细胞定位：
    Cell surface. Cell membrane; Multi-pass membrane protein. Endosome.
  • 蛋白家族：
    G-protein coupled receptor 1 family
  • 组织特异性：
    Detected in lung. Detected in oligodendrocytes in corpus callosum in brain cortex (at protein level). Expressed within the embryonic cerebral cortex, where it is enriched in the ventricular zone. In the adult brain, also expressed in oligodendrocytes, as
  • 数据库链接：

    KEGG: mmu:14745

    STRING: 10090.ENSMUSP00000052581

    UniGene: Mm.4772