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  4. Recombinant Mouse L-selectin (Sell)

Recombinant Mouse L-selectin (Sell)

  • 货号：
    CSB-CF020977MO
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
  • Uniprot No.：
  • 别名：
    Sell; Lnhr; Ly-22; Ly22; L-selectin; CD62 antigen-like family member L; Leukocyte adhesion molecule 1; LAM-1; Leukocyte-endothelial cell adhesion molecule 1; LECAM1; Lymph node homing receptor; Lymphocyte antigen 22; Lymphocyte surface MEL-14 antigen; CD antigen CD62L
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    39-372
  • 氨基酸序列
    WTYHYSEKPMNWENARKFCKQNYTDLVAIQNKREIEYLENTLPKSPYYYWIGIRKIGKMWTWVGTNKTLTKEAENWGAGEPNNKKSKEDCVEIYIKRERDSGKWNDDACHKRKAALCYTASCQPGSCNGRGECVETINNHTCICDAGYYGPQCQYVVQCEPLEAPELGTMDCIHPLGNFSFQSKCAFNCSEGRELLGTAETQCGASGNWSSPEPICQVVQCEPLEAPELGTMDCIHPLGNFSFQSKCAFNCSEGRELLGTAETQCGASGNWSSPEPICQETNRSFSKIKEGDYNPLFIPVAVMVTAFSGLAFLIWLARRLKKGKKSQERMDDPY
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Calcium-dependent lectin that mediates cell adhesion by binding to glycoproteins on neighboring cells. Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia.
  • 基因功能参考文献：
    1. data suggest that Ly6C(+)CD62L(+) infected monocytes served as a Trojan horse across the cerebral endothelium to induce brain infection. Therefore, CD62L should be considered as not only a temporally elicited antigen but also a disease-relevant leukocyte marker during the development of neurologic melioidosis. PMID: 27646437
    2. Myeloid-derived suppressor cell-induced L-selectin loss occurs through a contact-dependent, post-transcriptional mechanism that is independent of the major L-selectin sheddase, ADAM17, but results in significant elevation of circulating L-selectin in tumor-bearing mice. PMID: 27929373
    3. CD8(+) T-cells mediate ischemia reperfusion injury in a fatty liver through L-selectin. PMID: 28543181
    4. L-selectin is transported constitutively by the AP-1 complex, leading to the formation of a trans-Golgi network reserve pool; phosphorylation of the L-selectin tail blocks AP-1-dependent retrograde transport of L-selectin PMID: 28235798
    5. freeze and thaw of murine and human Tregs is associated with reduced expression of L-selectin (CD62L), which was previously established to be an important factor that contributes to the in vivo protective effects of Tregs PMID: 26693907
    6. endothelial colony-forming cells interact with activated neutrophils via PSGL-1 and L-selectin PMID: 24606340
    7. These data indicate that L-selectin plays a major role in the development of C protein induced polymyositis, whereas ICAM-1 plays a lesser role, if any. PMID: 24644046
    8. Data suggest that modulation of P- and L-selectins may constitute a promising therapeutic approach. PMID: 24177139
    9. These results put into question the utility of CD62L as a predictive biomarker for the efficacy of ex vivo-expanded T cells after ACT in lymphopenic conditions. PMID: 24218360
    10. The PSGL-1-L-selectin complex-induced signaling effects on neutrophil slow rolling and recruitment in vivo demonstrate the functional importance of this pathway. PMID: 24127491
    11. L-selectin-dependent signalling - exploring the different signals that potentially arise from distinct phases of the multi-step adhesion cascade and the contribution of known binding partners of L-selectin in this respon PMID: 23299028
    12. CD62L marks a mature natural killer (NK) cell subset by affecting the magnitude of the local NK cell response to adenovirus infection in the liver. PMID: 23509354
    13. Data indicate that naive lung CD4 cells supply the draining lymph nodes through a CD62L-independent, CCR7-dependent pathway. PMID: 23319636
    14. Signaling induced by ligation of L-selectin using mAb or endothelial cell-expressed ligand significantly enhanced the chemotaxis of murine T cells and B cells to SLC but not to other homeostatic chemokines. PMID: 22387549
    15. Pretreatment of cardiac mesoangioblasts with SDF-1 or transient expression of L-selectin induced a two- to three-fold increase in their transmigration and homing to the damaged heart. PMID: 21869829
    16. Hematopoietic lineage cells with Sca-1(high) expression and CD62L(neg/low) expression are characterized as multipotent progenitor cells, based on transient engraftment. PMID: 21998453
    17. the binding of L-selectin to its vascular and extravascular ligands is differentially regulated by pH. PMID: 21982762
    18. CD4 T cell co-stimulation with ICOS promotes the down-regulation of CCR7 and CD62L after activation, leading to a reduced return of activated CD4 T cells to the lymph nodes and a more efficient entry into the lungs. PMID: 21421907
    19. Data show a mechanism of control of CD62-L expression involving the miRNA let-7b. PMID: 21768364
    20. Atherosclerotic plaques did not exhibit any differences in cellular composition assessed by immunohistochemistry for CD68, CD3, CD4, and CD8 in ApoE(-/-)L-sel(-/-) as compared to ApoE(-/-) mice. PMID: 21760899
    21. migratory profile of CD62L-/- Tregs was that of an intermediate activated phenotype with higher expression of pro-inflammatory chemokine receptors compared to CD62LHi Tregs and much greater expression of CCR7 compared to CD62LLo Tregs. PMID: 21070606
    22. IL-7 drives Cdc25A-mediated T-cell proliferation, which prevents the nuclear translocation of Foxo1, leading to reduced expression of CD62L and the migration of T cells into circulation. PMID: 20831893
    23. In cultured cells and in mice, myeloid differentiation (MyD88)-dependent activation of B cells via Toll-like receptor TLR2 or TLR9 causes rapid loss of expression of CD62L by shedding caused by systemic infection with Salmonella typhimurium. PMID: 20660707
    24. Study suggests that L-selectin and ICAM-1 regulate Th2 and Th17 cell accumulation into the skin and lung, leading to the development of fibrosis. PMID: 20624949
    25. Division-linked differentiation predicts the differences in proportion of cells CD62L(high) observed between responses of different adoptive transfer number and within individual mice. PMID: 19859082
    26. lymphoma cells are the major contributors to levels of soluble forms of L-selectins in lymphoma-bearing mice PMID: 20001233
    27. Auditory stress enhances contact hypersensitivity (CH) response and that the augmentation of this CH response might be mediated through L-selectin, but not through P- or E-selectin pathways. PMID: 19948832
    28. Our data indicate a critical role for CD62L and lymph node homing for the process of homeostatic proliferation PMID: 19658092
    29. the role of L-selectin in induction of alloantigen-specific tolerance PMID: 11823485
    30. required for recruitment of dendritic cells to lymph nodes during mouse mammary tumor virus infection PMID: 11830477
    31. Surprisingly, L-selectin expressed on endogenous leukocytes also facilitates metastasis in both the syngeneic and xenogeneic (T and B lymphocyte deficient) systems PMID: 11854515
    32. CD62L expression is not essential for the development of T cell-mediated type 1 diabetes in NOD mice. PMID: 11884430
    33. L-selectin contributes to immune complex-induced skin injury cooperatively with ICAM-1 by regulating the accumulation of neutrophils and mast cells. PMID: 11884469
    34. L-selectin dimerization enhances tether formation to properly spaced ligand. PMID: 11907045
    35. Heparin's anti-inflammatory effects require glucosamine 6-O-sulfation and are mediated by blockade of L- and P-selectins. PMID: 12093896
    36. influences lymphocyte migration in vivo and increased levels present in certain pathologic conditions may adversely affect leukocyte migration PMID: 12165530
    37. CD62L expression is necessary for the diabetes-delaying effect of transfer of CD4+CD25+ splenocytes in vivo, but not for their suppressor function in vitro. PMID: 12193715
    38. Culture-activated T cells with the CD62 L-selectin(low) phenotype have potent antitumor activity and memory in vitro and in vivo and when adoptively transferred can eliminate advanced pulmonary metastases and cure subcutaneous tumors. PMID: 12218152
    39. L-selectin is involved in the P- and E-selectin-independent migration of cytotoxic T lymphocytes into inflamed skin. PMID: 12370362
    40. L-selectin regulates pulmonary fibrosis by mediating the accumulation of leukocytes. PMID: 12414509
    41. Loss of nasal passage and reproductive tract immunity in L-selectin-deficient mice at 16 days postprimary intranasal immunization with cholera toxin is due to delay of L-selectin(low)/alpha4beta7 integrin (double- low) B cells entering these sites. PMID: 12421944
    42. L-selectin cooperatively with ICAM-1 regulates induction of the immediate-type hypersensitivity response by mediating mast cell accumulation into inflammatory sites. PMID: 12682269
    43. L-selectin/PNAd, alpha4beta1 integrin/VCAM-1, and LFA-1, targets specific lymphocyte subsets to BALT. PMID: 12756264
    44. leukocyte-expressed PSGL-1 serves as the main L-selectin ligand in inflamed postcapillary venules. PMID: 12756271
    45. Data suggest that Trousseau syndrome is likely triggered by interactions of circulating carcinoma mucins with leukocyte L-selectin and platelet P-selectin without requiring accompanying thrombin generation. PMID: 12975470
    46. L-selectin shedding from antigen-activated T cells prevents reentry into peripheral lymph nodes PMID: 14597735
    47. In a chronic ileitis model, pathogenic CD4+ T cells alternatively engage L-selectin in order to recirculate to the chronically inflamed small intestine. PMID: 15699171
    48. L-selectin has a role in the growth of thymic lymphoma PMID: 15705798
    49. leukocytes can continue to roll in the absence of optimal P-selectin/PSGL-1 interaction using an alternative mechanism that involves P-selectin-, L-selectin-, and sLe(x)-bearing ligands PMID: 15743805
    50. preferential migration of CD62L+CD4+ cells into the appendix as compared to the colon PMID: 15905618

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  • 亚细胞定位：
    Cell membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Selectin/LECAM family
  • 组织特异性：
    Predominantly expressed in lymphoid tissue.
  • 数据库链接：

    KEGG: mmu:20343

    STRING: 10090.ENSMUSP00000027871

    UniGene: Mm.1461