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  4. Recombinant Mouse Interleukin-13 receptor subunit alpha-1 (Il13ra1)

Recombinant Mouse Interleukin-13 receptor subunit alpha-1 (Il13ra1)

  • 货号：
    CSB-CF011591MO
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
  • Uniprot No.：
  • 别名：
    Il13ra1; Il13r; Il13ra; Interleukin-13 receptor subunit alpha-1; IL-13 receptor subunit alpha-1; IL-13R subunit alpha-1; IL-13R-alpha-1; IL-13RA1; Interleukin-13-binding protein; Novel cytokine receptor 4; NR4; CD antigen CD213a1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    26-424
  • 氨基酸序列
    ATEVQPPVTNLSVSVENLCTIIWTWSPPEGASPNCTLRYFSHFDDQQDKKIAPETHRKEELPLDEKICLQVGSQCSANESEKPSPLVKKCISPPEGDPESAVTELKCIWHNLSYMKCSWLPGRNTSPDTHYTLYYWYSSLEKSRQCENIYREGQHIACSFKLTKVEPSFEHQNVQIMVKDNAGKIRPSCKIVSLTSYVKPDPPHIKHLLLKNGALLVQWKNPQNFRSRCLTYEVEVNNTQTDRHNILEVEEDKCQNSESDRNMEGTSCFQLPGVLADAVYTVRVRVKTNKLCFDDNKLWSDWSEAQSIGKEQNSTFYTTMLLTIPVFVAVAVIILLFYLKRLKIIIFPPIPDPGKIFKEMFGDQNDDTLHWKKYDIYEKQSKEETDSVVLIENLKKAAP
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Binds with low affinity to interleukin-13 (IL13). Together with IL4RA can form a functional receptor for IL13. Also serves as an alternate accessory protein to the common cytokine receptor gamma chain for interleukin-4 (IL4) signaling, but cannot replace the function of IL2RG in allowing enhanced interleukin-2 (IL2) binding activity.
  • 基因功能参考文献：
    1. Chronic stress significantly reduced the number of substantia nigra dopaminergic neurons in Il13a1 knock-out mice. PMID: 28427412
    2. Delivery of sIL13ralpha1 to mice by either gene transfer or recombinant protein decreases blood glucose levels. Surprisingly, the glucose-lowering effect of sIL13ralpha1 was preserved in mice lacking IL-13, demonstrating that IL-13 was not required for the effect. In contrast, deletion of IL-4 in mice eliminated the hypoglycemic effect of sIL13ralpha1. PMID: 28874358
    3. findings indicate that NOD mice lacking the IL-4Ralpha/IL-13Ralpha1 heteroreceptor (HR) display resistance to Type 1 Diabetes as the rise in blood glucose level and islet inflammation were significantly delayed in these HR-deficient relative to HR-sufficient mice PMID: 28646042
    4. IL-13Ralpha1 has a protective role in bleomycin-induced pulmonary injury and repair. PMID: 26153764
    5. These results show that activation of IL-13Ralpha1 is critical for key aspects of the immune and functional responses to Hb2 infection that facilitate expulsion. PMID: 26810038
    6. CAR T cells killed IL13Ra1- and/or IL13Ra2-positive cells in contrast to IL13Ra1- and IL13Ra2-negative controls PMID: 24841514
    7. IL-13Ralpha1 is a surface marker for M2 macrophages influencing their differentiation and function. PMID: 24281978
    8. Expression of IL-13Ralpha1 on dopaminergic neurons can increase their susceptibility to oxidative stress-mediated damage, thereby contributing to their preferential loss. PMID: 23169588
    9. IL-13Ralpha1 is the key receptor mediating airway hypersensitivity responses, mucus production, and transforming growth factor (TGF)-beta induction in response to aeroallergens. PMID: 21957151
    10. The loss of IL-13Ralpha1 on islet-reactive T cells may be a biomarker for fading regional immune regulation and progression to overt diabetes. PMID: 21617187
    11. peaks of upregulation in allergic bronchial asthma at 6 hours and 3-12 hours after the last antigen inhalation PMID: 20383033
    12. Il13ra1-/- mice showed less mortality after infection with Schistosoma mansoni and more susceptibility to Nippostrongylus brasiliensis. IL-13Ralpha1 was essential for allergen-induced airway hyperreactivity and mucus hypersecretion. PMID: 18066066
    13. Differential expression of IL-4Ralpha, IL-13Ralpha1, and gammac regulates relative cytokine sensitivity. PMID: 18852293
    14. IL-13R alpha 1 is required for allergen-induced airway hyperreactivity and mucus production but not for alternative macrophage activation. PMID: 18066066

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  • 亚细胞定位：
    Membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Type I cytokine receptor family, Type 5 subfamily
  • 组织特异性：
    Spleen, liver, thymus, heart, lung, kidney, testis, stomach, brain, skin, and colon; but not skeletal muscle.
  • 数据库链接：

    KEGG: mmu:16164

    STRING: 10090.ENSMUSP00000033418

    UniGene: Mm.24208