Recombinant Mouse Interleukin-1 receptor type 1 (Il1r1)

1. Study conclude that while interleukin-1 signaling is not critical for lipopolysaccharide induced anorexia or stress hormone release, interleukin-1 type 1 receptor expressed on brain endothelial cells, contributes to the febrile response to lipopolysaccharide. PMID: 28655587
2. Data indicate that IL-1RI and TNF-1R contribute to regulation of stress-induced, negatively reinforced drinking perhaps through overlapping signaling events downstream of these receptors, while leaving rewarding properties of alcohol largely unaffected. PMID: 27273552
3. interleukin-1 receptor 1/MyD88 signalling has roles in the development and progression of pulmonary hypertension PMID: 27418552
4. These results suggest that cytokines, particularly IL-1, areassociated with pulmonary anti-influenza immune response and inflammatory lung injury, particularly via the influence on neutrophil mobilization and inflammatory cytokine/chemokine production. PMID: 28585438
5. Using respective knockout mice it was found that LPS-mediated GIP secretion was selectively dependent on IL-1 signalling. PMID: 27350651
6. Results demonstrated the essential role of IL-1R1 in kindling-induced sleep disturbance by using transgenic IL-1R1 KO mice. Epilepsy-induced sleep disturbances were absent in the IL-1R1 KO mice, indicating the importance of IL-1 signals. The knockout of IL-1R1 did not change the seizure thresholds, suggesting that IL-1R1 signaling is not in involved in the kindling-induced epileptogenesis. PMID: 27875989
7. findings show elements of the IL-1 network, including IL-1alpha, IL-1beta, and IL-1R1, are essential for the optimal host response to VACV cutaneous infection PMID: 28468973
8. These data show that the normal distribution of surface glycosylation requires IL-1R, but not MyD88, and is not sufficient to prevent bacterial binding. PMID: 28223334
9. Study provides direct evidence that IL-1R1 is a potent target for adjunctive control of diazepam refractory status epilepticus in mice. Both pharmacological block and gene KO of IL-1R1 may reverse or prevent the progressive diazepam-refractoriness of status epilepticus in mice. Thus, combination of IL-1R1 antagonists with diazepam may be a novel strategy for the treatment of refractory prolonged status epilepticus. PMID: 27133574
10. IL-1R1 signaling via MyD88 is critical for the first step of inflammatory response to papain. PMID: 27569535
11. IL-1 receptor (IL-1R1) deficiency or blockade limits blood pressure elevation in this model by mitigating sodium reabsorption via the NKCC2 co-transporter in the nephron. PMID: 26712462
12. mediates signals by allograft parenchymal cells in generating the stimuli-provoking development and elicitation of optimal alloimmune responses to the grafts PMID: 26856697
13. data identify a previously unappreciated Trim24-dependent requirement for IL-1R expression on TH2 cells and an important nonredundant role for T-cell-intrinsic Trim24 in TH2-mediated allergy and antihelminth immunity PMID: 26787865
14. The results present identification of critical regions within the TIR domain of IL-1 receptor type in humans and mice. PMID: 26279140
15. IL-1R1/MyD88 signaling negatively regulates bone regeneration via impairment of mesenchymal stem cell proliferation, migration and differentiation by inhibiting the Akt/GSK-3beta/beta-catenin pathway. PMID: 27001940
16. adult mice lacking interleukin-1 receptor 1 (IL-1R1) exhibit increased expression of both the excitatory scaffolding protein postsynaptic density-95 (PSD-95) and inhibitory scaffolding proteingephyrin, respectively, in the hippocampus. PMID: 25263489
17. these studies demonstrate, through the use of novel transgenic mice, that IL1R1 on neurons and astrocytes differentially mediates aspects of sleep PMID: 25849975
18. Results suggest that the IL-1R1/IL-1ra complex regulates specific ethanol behaviors and affects the sensitivity to flurazepam sedation PMID: 25839897
19. IL-1R1 contributes to the IMQ-induced skin inflammation, and disruption of MyD88 signaling completely abrogates this response. PMID: 26147228
20. Data show that interleukin 1beta (IL-1beta) increased the expression of the IL-1 receptor type 1 in hippocampal neuronal cultures. PMID: 26305968
21. Because IL-1R-/- mice have impaired bystander responses during in vivo infection, we investigated whether IL-1R signaling was sufficient to induce TNF, IL-6, or CD86 expression in various innate immune cell types. PMID: 26034289
22. These results demonstrate this IL-1R1 restore model is a valuable tool for studying cell-type-specific functions of IL-1R1. PMID: 25698726
23. the NLRP3 inflammasome/IL-1RI axis is dispensable for PM10-facilitated allergic sensitization. PMID: 24988285
24. Contrary to prior studies, IL-1RI(-/-) mice are not robustly impaired on hippocampal-dependent memory. PMID: 24205219
25. major population of intestinal lamina propria lymphocytes expressing IL-1 receptor 1 (IL-1R1) is the lymphoid tissue inducer (LTi)-like cell PMID: 23750260
26. Overexpression of Sprouty4 or pharmacological inhibition of ERK upregulated IL-1R1 expression in primary T cells. PMID: 24732356
27. The role of IL-1 receptor and toll-like receptor 2 in the induction of MyD88-dependent immunization with a Coccidioides vaccine are reported. PMID: 24614655
28. These results demonstrate a role for the NLRP3 inflammasome in the control of Trypanosoma cruzi infection and identify NLRP3-mediated, caspase-1-dependent and IL-1R-independent nitric oxide production as a novel effector mechanism. PMID: 24098823
29. Both wild-type (WT) and eIL-1R1kd mice had increased circulating monocytes PMID: 24523548
30. IL-1 signaling, via IL-1R1 and MyD88, is required for development of postoperative ileus after intestinal manipulation in mice. PMID: 24067878
31. early stimulation of fibroblast IL-1R1 signaling during the inflammatory phase may prevent premature activation of a matrix-synthetic contractile phenotype until the wound is cleared, and the infarct microenvironment can support mesenchymal cell growth. PMID: 24078695
32. Knockout of IL-1RI protected mice from high fat diet-induced adipose tissue inflammation and insulin resistance. PMID: 22841542
33. These findings indicate an important interaction between dietary fat and IL-1R, relevant to optimal metabolic health. PMID: 23921145
34. These results suggest that IL-1RI is involved in normal growth plate development and extracellular matrix homeostasis and that it is significant in the physiological process of bone modeling. PMID: 23592480
35. These results demonstrate that IL-1alpha and IL-1R1 signaling is essential for microabscess formation, neutrophil recruiting chemokine expression, and acanthosis in psoriasis-like skin inflammation induced by imiquimod. PMID: 23407395
36. High viral persistence is found in the late stage of Theiler's virus infection in IL-1R-deficient mice. PMID: 22985464
37. Functional IL-1 receptor is required for Th17, but not Th2, cytokine production after in vitro antigen restimulation of lung cells. PMID: 23371061
38. data indicate that IL-1R1 signaling promotes virologic control during West Nile virus infection specifically within the central nervous system PMID: 23460727
39. study found that after infection with live influenza A virus, signaling through the interleukin 1 receptor was required for productive priming of CD8( ) T cells, but signaling through the pattern-recognition receptors TLR7 and RIG-I was not PMID: 23314004
40. IL-1RI signalling is a major antimicrobial effector pathway during acute brain-abscess formation. PMID: 22414156
41. Doxorubicin toxicity increased IL-1RI expression in cardiac tissues. Expression correlated with histology score in cardiotoxic injury. PMID: 22000485
42. Lymphocytic choriomeningitis virus is not cleared in IL-1R-deficient mice, and yet the infected mice develop neither splenomegaly nor hepatitis. PMID: 22674984
43. IL1R activation contributes to hypersomnolence that occurs after sleep loss PMID: 22387068
44. The immune pathogenesis of IL-1/IL-1R1 signaling on the ocular surface and in the lacrimal gland depends on tissue-specific CD4+ T cells and activation of IL-1R1-expressing epithelial and stromal cells. PMID: 22231738
45. These results indicate that IL-1R signaling is required at multiple steps during the course of sensitization and challenge to elicit Contact hypersensitivity. PMID: 22238457
46. TIR8 has a nonredundant effect in modulating the inflammation caused by Pseudomonas aeruginosa, in particular, by negatively regulating IL-1RI signaling, which plays a major role in the pathogenesis of bacterial pneumonia. PMID: 22025515
47. Inhibition of MyD88- or IL-1 receptor signalling reduces neointima formation in response to carotid artery injury. PMID: 21421554
48. The response in aged IL-1R knockout mice differs from wild-type mice in that starvation increases atrophy and is associated with decreased cell proliferation rather than increased apoptosis. PMID: 20605606
49. Lack of IL-1RI protects against HFD-induced IR coincident with reduced local adipose tissue inflammation, despite equivalent immune cell recruitment. PMID: 21515850
50. Following exposure to cigarette smoke in IL-1RI-deficient mice, PTX3 expression is not enhanced compared to wild-type mice. PMID: 20920344

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KEGG: mmu:16177

STRING: 10090.ENSMUSP00000027241

UniGene: Mm.896