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  4. Recombinant Mouse Interferon gamma receptor 1 (Ifngr1)

Recombinant Mouse Interferon gamma receptor 1 (Ifngr1)

  • 货号：
    CSB-CF011051MO
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
  • Uniprot No.：
  • 别名：
    Ifngr1; Ifngr; Interferon gamma receptor 1; IFN-gamma receptor 1; IFN-gamma-R1; Interferon gamma receptor alpha-chain; IFN-gamma-R-alpha; CD antigen CD119
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    26-477
  • 氨基酸序列
    ALTSTEDPEPPSVPVPTNVLIKSYNLNPVVCWEYQNMSQTPIFTVQVKVYSGSWTDSCTN ISDHCCNIYEQIMYPDVSAWARVKAKVGQKESDYARSKEFLMCLKGKVGPPGLEIRRKKEEQLSVLVFHPEVVVNGESQGTMFGDGSTCYTFDYTVYVEHNRSGEILHTKHTVEKEECNE TLCELNISVSTLDSRYCISVDGISSFWQVRTEKSKDVCIPPFHDDRKDSIWILVVAPLTVFTVVILVFAYWYTKKNSFKRKSIMLPKSLLSVVKSATLETKPESKYSLVTPHQPAVLESE TVICEEPLSTVTAPDSPEAAEQEELSKETKALEAGGSTSAMTPDSPPTPTQRRSFSLLSSNQSGPCSLTAYHSRNGSDSGLVGSGSSISDLESLPNNNSETKMAEHDPPPVRKAPMASGYDKPHMLVDVLVDVGGKESLMGYRLTGEAQELS
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Receptor subunit for interferon gamma/INFG that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation (, PubMed:20926559, PubMed:27286456). Associates with transmembrane accessory factor IFNGR2 to form a functional receptor. Upon ligand binding, the intracellular domain of IFNGR1 opens out to allow association of downstream signaling components JAK1 and JAK2. In turn, activated JAK1 phosphorylates IFNGR1 to form a docking site for STAT1. Subsequent phosphorylation of STAT1 leads to its dimerization, translocation to the nucleus, and stimulation of target gene transcription. STAT3 can also be activated in a similar manner although activation seems weaker. IFNGR1 intracellular domain phosphorylation also provides a docking site for SOCS1 that regulates the JAK-STAT pathway by competing with STAT1 binding to IFNGR1.
  • 基因功能参考文献：
    1. significant upregulation of genes involved in inflammation and tissue remodeling in intestinal tumors of Ifngr1-/-ApcMin/+ mice when compared to those in Ifngr1+/+ApcMin/+ mice PMID: 27286456
    2. These findings suggest that IFNGR1 signaling plays a pivotal role in placental pathology and subsequent adverse pregnancy outcomes during severe malaria. Our findings may increase our understanding of how disease aggravation occurs during malaria during pregnancy. PMID: 29117241
    3. Down regulation of macrophage IFNGR1 resists infection by Listeria monocytogenes. PMID: 28542482
    4. Marginal zone macrophage population loss is dependent on interferon gamma receptor but independent of T cells or tumor necrosis factor alpha receptor 1 signaling pathways. PMID: 28808159
    5. These results suggest that pulmonary C-fibers affect IFNGR1 expression by inducing IFN-alpha to regulate IFN-gamma-mediated airway inflammation and airway hyperresponsiveness. PMID: 28772166
    6. data define a novel B cell-intrinsic IFN-gammaR signaling pathway specific to Spt-GC development and autoimmunity. PMID: 27069112
    7. B cell type 1 IFN receptor signals accelerate, but are not required for, lupus development. PMID: 27069113
    8. These data offer direct evidence that tumor cell loss of the IFNGR1 gene, which results in loss of IFN-g signaling, leads to resistance to anti-CTLA-4 therapy. PMID: 27667683
    9. These data indicate that both GKO and GRKO mice fail to develop an IFN-gamma-mediated antiviral response, but differ in regulation of the inflammatory response to infection. PMID: 24204622
    10. IFN-gamma Ralpha is a key determinant of CD8+ T cell-mediated tumor elimination or tumor escape and relapse in FVB mouse. PMID: 24324806
    11. IFN-lambdaR limits T cell responses and memory after transient infection but augments T cell responses during persisting infection. PMID: 24646741
    12. Data indicate that prolonged IFNgammaR-/- dendritic cell survival promotes CD4 T cell expansion. PMID: 24523506
    13. IFNGR1 transcription is mediated by CTCF protein. PMID: 22836578
    14. Gamma interferon (IFN-gamma) receptor restricts systemic dengue virus replication and prevents paralysis in IFN-alpha/beta receptor-deficient mice. PMID: 22973027
    15. The present data indicate that IFN-gammaR plays an essential role in mediating the early immune mechanisms induced by the infection of erythrocytic stages of P. yoelii 17XL parasite, leading to host survival. PMID: 22392138
    16. these results demonstrate that IFN-gammaR may play a key role in CD4( ) T cell-mediated beta-cell destruction PMID: 22865049
    17. Cholesterol dependent modulation of IFNgamma mediated receptor subunit interaction in Leishmania donovani infected macrophages involve differential raft partitioning of IFNgammaR subunits. PMID: 21931549
    18. IFN-gamma is capable of promoting GVL effects via mechanisms independent of its interaction with leukemia cells. PMID: 21835954
    19. Mice lacking gamma interferon receptors are susceptible to junin virus infection. PMID: 20926559
    20. In contrast to peptide vaccination, IFN-gamma receptor signaling in CD8-positive T cells contributes to memory fate decision in response to lymphopenia, an effect that is fully reversed by high-affinity T cell receptor (TCR) ligands. PMID: 20164422
    21. IFNGR signaling in endothelial cells activates a potent peripheral negative feedback circuit that protects vascularized grafts from occlusive transplant vasculopathy. PMID: 20049875
    22. Inhibition of methylcholanthrene-induced carcinogenesis by an interferon gamma receptor-dependent foreign body reaction. PMID: 12045246
    23. Trophoblast cell invasion is accelerated in mice with a genetic deficiency in the Ifngr. PMID: 12885563
    24. Increased expresion in senescent spinal motoneurons PMID: 15505791
    25. role of tyrosine 441 in attenuating SOCS-1 mediated STAT1 activation PMID: 15522878
    26. required for the protective pulmonary inflammatory response to Cryptococcus neoformans PMID: 15731080
    27. Development of IFN-gamma-producing B cells by either T-helper type 1 cells or IL-12/IL-18 is absolutely dependent on expression of the IFN-gamma receptor. PMID: 15905519
    28. severe impairment in the capacity of CD8 T cells lacking type I IFNR to expand in normal type I IFNR wild-type C57BL/6 hosts after LCMV infection PMID: 16585541
    29. We show that demyelination in response to cuprizone is delayed in mice lacking the binding chain of IFNgamma receptor. In addition, IFNgammaR(-/-) mice exhibited an accelerated remyelination process after cuprizone was removed from the diet. PMID: 16651614
    30. demonstrates for first time that postnatal blocking of IFN-gamma function prevents atherosclerotic plaque formation in apoEKO mice by overexpressing IFN-gamma receptor PMID: 17510508
    31. IFNGR knockout mice were not protected from ischemia/reperfusion-induced liver damage. PMID: 17935177
    32. IFN-gamma concentration is both necessary and sufficient for graft rejection in IFN-gammaR1-deficient mice, inhibiting the development of heterologous, IFN-gammaR1-expressing, haematopoietic cell lineages. PMID: 18232731
    33. Graft-versus-host disease causes failure of donor hematopoiesis and lymphopoiesis in interferon-gamma receptor-deficient hosts. PMID: 18552211
    34. IFN-gammaR is a key element in the molecular machinery through which resting spinal microglia transform into an activated state that drives neuropathic pain PMID: 19380717
    35. in the absence of host cell IFN-gammaR expression, both Th1 and Th2 cells lead to increased burden of C. trachomatis PMID: 19561106

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  • 亚细胞定位：
    Cell membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Type II cytokine receptor family
  • 数据库链接：

    KEGG: mmu:15979

    STRING: 10090.ENSMUSP00000020188

    UniGene: Mm.549