Recombinant Mouse Histamine H1 receptor (Hrh1)

1. Data (including data from studies in knockout mice) suggest that sleep-promoting effect of dietary supplement rice bran is dependent on Hrh1 antagonism; rice bran fully inhibits Hrh1 agonist-induced increase in action potential frequency in tuberomammillary nucleus neurons. PMID: 28722302
2. Study showed that the sleep-wake cycle in H1-/- mice was affected both quantitatively and qualitatively: long-term abolition of histamine impairs cortical EEG, affects sleep-wake qualities and causes sleepiness facing behavioral challenges PMID: 26723880
3. this study shows that the histamine 1 receptor might be useful therapeutic target for treatment of metal allergy PMID: 27035718
4. Sympathetic tone changed in H1R-, but not H2R- or H3R-null mice. PMID: 25680462
5. The results of this study suggest that H1R deficiency in mice is associated with pronounced deficits in hippocampus-dependent spatial learning and memory. PMID: 24862254
6. These results reveal a crucial role for H1- and H4-receptors for Th2 migration and cytokine secretion in a Th2-driven model of skin inflammation. PMID: 24503582
7. histamine receptor H1 and histamine receptor H2 reciprocally regulate inflammation in the ligation-induced arteriosclerosis PMID: 24200155
8. Histamine demonstrably inhibited ACh-induced sweating in both mice and humans via H1R-mediated signaling. PMID: 23900020
9. Histamine H1 receptors (but not H2) mediate emotional memory consolidation impairment. PMID: 22986235
10. Histamine H1 receptors in the amygdala are not involved in anxiety-like behavior but are involved in emotional memory. PMID: 22772356
11. This study provides a potential mechanism of H1R-mediated signaling and NF-kB pathway crosstalk in allergic inflammationptor PMID: 23075496
12. Neuronal damage is significantly increased in H1R knock-out mice following status epilepticus. PMID: 22348791
13. Histamine H1 Receptor expression by CD11B(+) cells is not required for susceptibility to experimental allergic encephalomyelitis. PMID: 23121973
14. An increase in regulatory T cells was observed, yet these cells were incapable of controlling myocarditis in H(1)R(-/-) mice. an increase in regulatory T cells was observed, yet these cells were incapable of controlling myocarditis in H(1)R(-/-) mice. PMID: 22078271
15. histamine signaling through the H1R on dendritic cells is an important early event conditioning the quality of the skin effector immune response. PMID: 21269673
16. These data suggest that histamine H1 and H2 receptor signaling may regulate glucose and lipid metabolism and development of hyperlipidemia-induced nonalcoholic steatohepatitis. PMID: 20566747
17. endothelial H(1)R expression reduces BBB permeability, suggesting that endothelial H(1)R signaling may be important in the maintenance of cerebrovascular integrity PMID: 20956310
18. The study suggest that H1 receptors play a pivotal role in the regulation of seizure intensity and duration as well as seizure-induced neuronal damage in the immature P9 mice. PMID: 20359868
19. Regulation of sleep/wake states is completely achieved by OX(2)R-expressing neurones without involving H(1)R-mediated pathways. Maintenance of basal physiological sleep/wake states is fully achieved without both H(1) and OX(1) receptors. PMID: 19694625
20. H1 receptors have a role in the circadian variation in V(E) through control of acid-base status and metabolism in mice. PMID: 20217356
21. Histamine H1 receptor activation drives the formation of atherosclerotic lesions through an increased vascular permeability for LDL, which is associated with an enhanced secondary aortic and systemic inflammation. PMID: 20203300
22. H1R-/- mice were not protected against K/BxN serum-induced arthritis. PMID: 19762454
23. Histamine H1 receptors play an important role in nasal allergy symptoms induced by histamine in a study comparing histamine H1 receptor-deficient mice with wild-type. PMID: 12095164
24. congenic mapping links Bphs to the histamine H1 receptor gene(Hrh1); natural alleles of Hrh1 control both the autoimmune T cell and vascular responses regulated by histamine after Bordetella pertussis toxin sensitization PMID: 12142541
25. Bphs/Hrh1 plays a role in the genetic control of responsiveness to pertussis toxin. PMID: 12595443
26. histamine H(1)-R signaling pathway may be independent or downstream of the POMC/MC-4R signaling. PMID: 12746338
27. presence of histamine h1 receptor but not histamine h2 receptor was found in undifferentiated embryonic stem cells PMID: 12755409
28. Histaminergic mechanisms through H1 receptors play a crucial role not only in amygdaloid kindled seizures but also in the development of amygdaloid kindling. PMID: 15030492
29. histamine H(1)-Rs are crucial for the regulation of feeding rhythm and in mediating the effects of leptin PMID: 15331534
30. Histaminergic neurons protect the developing hippocampus from KA-induced neuronal damage, with regulation of neuronal survival being at least partly mediated through H1 receptors. PMID: 16436594
31. Central histamine contributes via the H1 receptor to changes in metabolic rate during hypoxia to increasehypoxic ventilatory decline in conscious mice. PMID: 16540381
32. Data establish a role for histamine and histamine type 1 receptors in promoting the migration of Th2 cells into sites of allergen exposure. PMID: 16680192
33. role of histamine H1 receptors in airway allergic inflammation; findings show that histamine plays an important role via H1 receptors in the development of T helper type 2 responses to enhance airway inflammation PMID: 16685135
34. Histamine effect was mediated by activation of histamine H1 and H2 receptors that induced inward currents and depolarization. PMID: 16738217
35. histamine modulates ventilation by affecting metabolism and arousal state via H1 receptors PMID: 16875510
36. The results of this study demonstrates that both H1 is involved in learning and memory processes for which the frontal cortex, amygdala and hippocampus interact. PMID: 17145090
37. Histamine H1 receptors are upregulated during bone marrow regeneration in mice. PMID: 17420012
38. Cytokine-induced endothelial intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 expressionwas inhibited by tecastemazole in a manner independent of H1 receptor antagonism. PMID: 17517105
39. Data suggest that histamine receptor H1 is required for TCR-mediated p38 MAPK activation and optimal interferon-gamma production in mice. PMID: 17965772
40. The motivational effects of novelty are diminished in histamine H1-receptor knock- out mice, possibly due to a dysfunctional brain reward system. PMID: 18331338
41. Results describe the roles of histamine H1 receptors on cognition PMID: 18345498
42. Initial increases in ventilation were augmented during dark periods. H1 receptors had no major relationship with circadian variation, but affected the declined phase. PMID: 18358081
43. data are the first to demonstrate that structural polymorphisms influencing cell surface expression of a G protein-coupled receptor in T cells regulates immune functions and autoimmune disease susceptibility PMID: 18490747
44. ELM and long-term PM are impaired in the homozygous H1R-KO mice. Neurochemical assays revealed that the H1R-KO mice had significantly lower levels of AChE activity in the hippocampus and dopamine turnover in the cerebellum. PMID: 18926883
45. HR1 immunoreactivity was observed on dopaminergic amacrine cells, calretinin-positive ganglion cells and axon bundles in the ganglion cell layer. PMID: 19015005
46. Genetic inactivation of the H1 receptor in the mouse leads to spatial working and reference memory impairments, while having no significant effect on emotional behaviour in the light-dark test. PMID: 19413573
47. Bone marrow-derived mast cell-elaborated histamine inhibits CD4positiveCD25positive regulatory T cell suppressor function by signaling through the histamine H1 receptor. PMID: 19667094

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KEGG: mmu:15465

STRING: 10090.ENSMUSP00000086383

UniGene: Mm.333327