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  4. Recombinant Mouse Gap junction beta-6 protein (Gjb6)

Recombinant Mouse Gap junction beta-6 protein (Gjb6)

  • 货号：
    CSB-CF009456MO
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
    Gjb6
  • Uniprot No.：
  • 别名：
    Gjb6; Cxn-30; Gap junction beta-6 protein; Connexin-30; Cx30
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-261
  • 氨基酸序列
    MDWGTLHTVIGGVNKHSTSIGKVWITVIFIFRVMILVVAAQEVWGDEQEDFVCNTLQPGC KNVCYDHFFPVSHIRLWALQLIFVSTPALLVAMHVAYYRHETARKFIRGEKRNEFKDLED IKRQKVRIEGSLWWTYTSSIFFRIIFEAAFMYVFYFLYNGYHLPWVLKCGIDPCPNLVDC FISRPTEKTVFTVFMISASVICMLLNVAELCYLLLKLCFRRSKRTQAQRNHPNHALKESK QNEMNELISDSGQNAITSFPS
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
  • 基因功能参考文献：
    1. Data show that the passive compliance of the cochlear partition and active frequency tuning of the basilar membrane are enhanced in the cochleae of CD-1onnexin-30 (Cx30)(A88V/A88V) compared to CBA/J mice with sensitive high-frequency hearing. PMID: 28220769
    2. Results demonstrate that Cx43, but not Cx30, is crucial for adult neurogenesis in the hippocampus. PMID: 28689039
    3. connexin 30 controls astroglial polarity during development PMID: 29475972
    4. In Cx30 and Cx26 knock-out animals, inner hair cells remained stuck at a prehearing stage of development. PMID: 28077706
    5. Connexin 30, but not connexin 43, hemichannels close upon protein kinase C activation, illustrating that connexin hemichannels display not only isoform-specific permeability profiles but also isoform-specific regulation by protein kinase C. PMID: 26400258
    6. four unique Cx30 mutants might cause disease through different mechanisms that also likely include their selective trans-dominant effects on coexpressed connexins. PMID: 24522190
    7. The cortex modafinil injection increases the expression of mRNA and protein of connexin 30. PMID: 23665355
    8. The Cx30A88V mutation triggers hyperproliferation in the skin and changes the cochlear homeostasis in mice. PMID: 24685692
    9. Connexin30 is expressed at significantly higher levels in the buccal mucosa than the epidermis and, unlike in skin, it is rapidly down-regulated at the wound edge within 6 hours of wounding. This may underlie the rapid healing of the buccal mucosa. PMID: 23627777
    10. The observations demonstrate a role for Cx30 and intercellular communication in regulating repair responses in an epithelial tissue. PMID: 23424196
    11. We showed co-expression of Cx30 and p63 in developing mouse hair follicles and nail units. PMID: 23219093
    12. in the Cx30 knock-out mouse model, defective Cx26 expression is the likely cause of deafness, and in contrast to current opinion, Cx30 is dispensable for cochlear functions PMID: 23303923
    13. This study demonistrated that Cx30/Cx47 double-deficient mice has the functional role of both connexins for interastrocytic, interoligodendrocytic, and panglial coupling, and show that both connexins are required for maintenance of myelin. PMID: 22649229
    14. Loss of Cx30 and the white matter pathology observed does not affect expression of experimental autoimmune encephalitis; astrocyte gap junctions do not regulate autoimmune inflammation. PMID: 22342190
    15. This study suggested that cx30 defiency affect expression levels of glial glutamate transporters within the cerebrum. PMID: 22037505
    16. Employing tracer coupling analyses in acute slices of Cx30 deficient mice demonstrate that Cx30 makes a substantial contribution to interastrocytic gap junctional communication in the mouse hippocampus. PMID: 21264956
    17. These results of this study suggested that alterations of astrocyte connexins might be involved in the suicide process and provide further evidence implicating astrocytes in psychopathology. PMID: 21571253
    18. loss of the ability of ENaC to respond to changes in sodium levels contributes to salt-sensitive hypertension in Cx30(-/-) mice PMID: 21075848
    19. Cx30 is functionally expressed, in low abundance, in the SA node of the adult mouse heart where it participates in heart rate regulation. PMID: 19679680
    20. Cx30 (Gjb6) deficient mice exhibit a severe constitutive hearing impairment.The Cx30 deficient mice may represent a valuable model to study the mechanism of the hearing loss in human patients carrying a homozygous deletion of the CX30 gene . PMID: 12490528
    21. Elimination of connexin30 can alter reactivity to novel environments. Importance of gap-junctional signalling in behavioural processes. PMID: 12911759
    22. Cx30 is abundant in late-pregnant and early lactating gland epithelium. PMID: 17120054
    23. In the absence of the Cx30 gene, Cx26 expressed from extra alleles completely restored hearing sensitivity and prevented hair cell death in deaf Cx30-/- mice PMID: 17227867
    24. Connexin30 deficiency causes instrastrial fluid-blood barrier disruption within the cochlear stria vascularis. PMID: 17400755
    25. Cx30 immunoreactivity was found extensively in vestibular supporting cells and connective tissue cells. PMID: 17702002
    26. Expression of Cx30 and Cx43 a is upregulated in cortical astrocytes cocultured with neurons. PMID: 18512249
    27. effects of Cx30 null mutation on GJ-mediated ionic and metabolic coupling in the cochlea of mice PMID: 19116647
    28. Mechanosensitive Cx30 hemichannels have an integral role in pressure natriuresis by releasing ATP into the tubular fluid, which inhibits salt and water reabsorption. PMID: 19478095

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein. Cell junction, gap junction.
  • 蛋白家族：
    Connexin family, Beta-type (group I) subfamily
  • 组织特异性：
    Highly expressed in adult brain and skin. Less in uterus, lung and eye. Very low in testis and sciatic nerve. No expression before birth.
  • 数据库链接：

    KEGG: mmu:14623

    STRING: 10090.ENSMUSP00000035630

    UniGene: Mm.25652