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  4. Recombinant Mouse Dual oxidase maturation factor 1 (Duoxa1)

Recombinant Mouse Dual oxidase maturation factor 1 (Duoxa1)

  • 货号：
    CSB-CF007230MO
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
    Duoxa1
  • Uniprot No.：
  • 别名：
    Duoxa1; Dual oxidase maturation factor 1; Dual oxidase activator 1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-341
  • 氨基酸序列
    MAALGHTLPFYTGTKPTFPMDTTLAVIITIFLTALVTFIIILPGIRGKTRLFWLLRVVTS LFIGAVILAVNFSSEWSVGHVNANTTYKAFSPKWVSVDVGLQIGLGGVNITLTGTPVQQL NETINYNEAFAWRLGRSYAEEYAKALEKGLPDPVLYLAEKFTPRSPCGLYNQYRLAGHYA SAMLWVAFLCWLLANVMLSMPVLVYGGHMLLATGLFQLLALFFFSMTTSLISPCPLRLGT AVLHTHHGPAFWITLATGLLCILLGLVMAVAHRMQPHRLKAFFNQSSEDPVLEWGSEEGG LLSPHYRSIAESPETQDIPMSVASSETCFKEEHPKESDCSL
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May be required for the maturation and the transport from the endoplasmic reticulum to the plasma membrane of functional DUOX1.
  • 基因功能参考文献：
    1. The proliferation and migration of granule cells was delayed after P15 in Duoxa-/- mice. However, these changes disappeared by P25. Although the cerebellar structure of Duoxa-/- mice was not significantly different from that of Wt mice at P25, motor coordination was impaired. It was also found that the amplitude of paired-pulse facilitation at parallel fiber-Purkinje cell synapses decreased in Duoxa-/- mice. PMID: 26914863
    2. DUOXA1 overexpression in muscle stem cells induces apoptosis and inhibits differentiation through DUOX1 and ASK1. PMID: 24410844
    3. DUOXA1 is a novel p53-regulated neurogenic factor involved in p53 dependent neuronal differentiation. PMID: 21362455
    4. Nip1 has an important role in the guidance of neuronal differentiation through ROS generation and modulation of intermediate filaments PMID: 20233719
  • 亚细胞定位：
    Membrane; Multi-pass membrane protein.
  • 蛋白家族：
    DUOXA family
  • 数据库链接：

    KEGG: mmu:213696

    STRING: 10090.ENSMUSP00000028653

    UniGene: Mm.247121