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  4. Recombinant Mouse Claudin-1 (Cldn1)

Recombinant Mouse Claudin-1 (Cldn1)

  • 货号：
    CSB-CF005490MO
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
    Cldn1
  • Uniprot No.：
  • 别名：
    Cldn1; Claudin-1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-211
  • 氨基酸序列
    MANAGLQLLGFILASLGWIGSIVSTALPQWKIYSYAGDNIVTAQAIYEGLWMSCVSQSTG QIQCKVFDSLLNLNSTLQATRALMVIGILLGLIAIFVSTIGMKCMRCLEDDEVQKMWMAV IGGIIFLISGLATLVATAWYGNRIVQEFYDPLTPINARYEFGQALFTGWAAASLCLLGGV LLSCSCPRKTTSYPTPRPYPKPTPSSGKDYV
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. While some claudin family members play essential roles in the formation of impermeable barriers, others mediate the permeability to ions and small molecules. Often, several claudin family members are coexpressed and interact with each other, and this determines the overall permeability. CLDN1 is required to prevent the paracellular diffusion of small molecules through tight junctions in the epidermis and is required for the normal barrier function of the skin. Required for normal water homeostasis and to prevent excessive water loss through the skin, probably via an indirect effect on the expression levels of other proteins, since CLDN1 itself seems to be dispensable for water barrier formation in keratinocyte tight junctions.
  • 基因功能参考文献：
    1. Taken together, these results demonstrate that BTZ-induced claudin 1 expression may be a valuable therapeutic approach for AD. PMID: 28859979
    2. Results suggest that TLR4-dependent claudin-1 internalization and secondary anion secretion contribute to irinotecan-induced diarrhea. PMID: 27550942
    3. The data suggested that miR-29a may regulate tumor growth and migration by targeting CLDN1. PMID: 28342862
    4. Data show that the spatiotemporal expression of claudin-1 is dysregulated in homeobox (Msx) genes Msx1d/d/Msx2d/d uteri. PMID: 26667042
    5. Cldn-1 is a positive regulator of osteoblast proliferation and differentiation. PMID: 25479235
    6. We further demonstrate that KRT76 interacts with CLDN1 and propose that this interaction is necessary to correctly position CLDN1 in tight junctions. PMID: 25340345
    7. MIR29 targets and reduces expression of CLDN1 and NKRF to increase intestinal permeability in inflammatory bowel disease. PMID: 25277410
    8. Occludin and Claudin-1 expressions in the large intestine are under the circadian control, which is associated with temporal regulation of colonic permeability and also susceptibility to colitis. PMID: 24845399
    9. regulates intestinal epithelial homeostasis via regulation of Notch-signalling PMID: 23766441
    10. Downregulation of Sirt1 and upregulation of the tight junction protein Claudin-1 by SIRT1-mediated epigenetic regulation in podocytes contributed to albuminuria. PMID: 24141423
    11. Cldn1(-/-) mice exhibited the abnormal stratum granulosum formation and stratum corneum barrier defects. PMID: 23433550
    12. miR-155 may prevent tumorigenesis in human ovarian cancer through downregulation of CLDN1 PMID: 23523916
    13. Claudin-1 is expressed at the variety of epithelial tissues in inner ear including Organ of Corti, stria vascularis, Reissner's membrane, spiral limbus, vestibular sensory epithelia, dark cell area. PMID: 14698084
    14. we identified Cldn1, Cldn2 and Cldn11 as genes that discriminate between diverse types of M2 macrophages PMID: 22268650
    15. Mouse CLDN1 (mCLDN1) supported HCV genotype 2a infection with only moderate efficiency. indicating CLDN1 also contributes to the restricted species tropism of HCV. CLDN1 also contributes to the restricted species tropism of HCV. PMID: 19889758
    16. dynamic behavior of paired strands of this protein in cell membranes PMID: 12651952
    17. Thr203 of claudin-1 is required to enhance the barrier function of claudin-1-based tight junctions, probably via its phosphorylation and subsequent integration into tight junctions. PMID: 15051488
    18. In the absence of follicle-stimulating hormone receptor signaling, claudin-1 decreases in ovarian surface epithelium and tumors in comparison to wild type. PMID: 17217615
    19. Claudin-1 was located in murine Langerhans cells (LC) in epidermis. TGF-beta stimulated accumulation of claudin-1 mRNA and protein when added to cultured bone marrow cells. Claudin-1 may have a function in adhesion and migration of LC. PMID: 17508021
    20. Cldn1 is localized in the epidermis and nail and in the dorsal surface of the tongue and glandular compartment of the stomach but is absent from the oral mucosa and the keratinized compartment of the stomach. PMID: 17828607
    21. Nectin plays a novel role in the co-localization of JAM and claudin at the same cell-cell adhesion membrane domains. PMID: 18547333
    22. Claudin-1 is a p63 target gene with a crucial role in epithelial development PMID: 18648642
    23. The induction of tight-junction protein claudin-1 and paracellular permeability during the differentiation of osteoblast-like MC3T3-E1 cells after treatment with IGF-I is regulated via a MAP-kinase pathway, but not with respect to gap junctions. PMID: 18855015
    24. This study investigated whether the conserved "dFynPl" sequence is essential for claudin-1, continuous strand-forming claudin, to form TJ strands PMID: 19234713
    25. LNX1p80 is involved in the ubiquitylation, endocytosis and lysosomal degradation of claudins, and the turnover of tight junctions is regulated by ubiquitylation. PMID: 19295125

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  • 亚细胞定位：
    Cell junction, tight junction. Cell membrane; Multi-pass membrane protein. Basolateral cell membrane.
  • 蛋白家族：
    Claudin family
  • 组织特异性：
    Detected in epidermis and liver (at protein level). Widely expressed, with highest levels in liver and kidney.
  • 数据库链接：

    KEGG: mmu:12737

    STRING: 10090.ENSMUSP00000023154

    UniGene: Mm.289441