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  4. Recombinant Mouse Cadherin-2 (Cdh2)

Recombinant Mouse Cadherin-2 (Cdh2)

  • 货号：
    CSB-CF005045MO
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
  • Uniprot No.：
  • 别名：
    Cdh2; Cadherin-2; Neural cadherin; N-cadherin; CD antigen CD325
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    160-906
  • 氨基酸序列
    DWVIPPINLPENSRGPFPQELVRIRSDRDKNLSLRYSVTGPGADQPPTGIFIINPISGQLSVTKPLDRELIARFHLRAHAVDINGNQVENPIDIVINVIDMNDNRPEFLHQVWNGSVPEGSKPGTYVMTVTAIDADDPNALNGMLRYRILSQAPSTPSPNMFTINNETGDIITVAAGLDREKVQQYTLIIQATDMEGNPTYGLSNTATAVITVTDVNDNPPEFTAMTFYGEVPENRVDVIVANLTVTDKDQPHTPAWNAAYRISGGDPTGRFAILTDPNSNDGLVTVVKPIDFETNRMFVLTVAAENQVPLAKGIQHPPQSTATVSVTVIDVNENPYFAPNPKIIRQEEGLHAGTMLTTLTAQDPDRYMQQNIRYTKLSDPANWLKIDPVNGQITTIAVLDRESPNVKNNIYNATFLASDNGIPPMSGTGTLQIYLLDINDNAPQVLPQEAETCETPEPNSINITALDYDIDPNAGPFAFDLPLSPVTIKRNWTINRLNGDFAQLNLKIKFLEAGIYEVPIIITDSGNPPKSNISILRVKVCQCDSNGDCTDVDRIVGAGLGTGAIIAILLCIIILLILVLMFVVWMKRRDKERQAKQLLIDPEDDVRDNILKYDEEGGGEEDQDYDLSQLQQPDTVEPDAIKPVGIRRLDERPIHAEPQYPVRSAAPHPGDIGDFINEGLKAADNDPTAPPYDSLLVFDYEGSGSTAGSLSSLNSSSSGGDQDYDYLNDWGPRFKKLADMYGGGDD
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Calcium-dependent cell adhesion protein; preferentially mediates homotypic cell-cell adhesion by dimerization with a CDH2 chain from another cell. Cadherins may thus contribute to the sorting of heterogeneous cell types. Acts as a regulator of neural stem cells quiescence by mediating anchorage of neural stem cells to ependymocytes in the adult subependymal zone: upon cleavage by MMP24, CDH2-mediated anchorage is affected, leading to modulate neural stem cell quiescence. Plays a role in cell-to-cell junction formation between pancreatic beta cells and neural crest stem (NCS) cells, promoting the formation of processes by NCS cells. CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density.
  • 基因功能参考文献：
    1. The FGFR4-388arg variant promotes lung cancer progression by N-cadherin induction. PMID: 29402970
    2. regulation of vesicle endocytosis was mediated at the molecular level by N-cadherin in a release activity-dependent manner. Because of its endocytosis enhancing function, N-cadherin might play an important role in the coupling of vesicle exo- and endocytosis. PMID: 28106089
    3. Results indicate that embryos that express N-cad show altered BMP activity, resulting in an atrophied epiblast, inappropriate loss of cells into the amniotic cavity and inefficient patterning of the extraembryonic mesoderm. PMID: 27217206
    4. The s propose that AmotL1 is an essential effector of the N-cadherin mediated endothelial/pericyte junctional complex. PMID: 27464479
    5. Reelin directly promotes N-cadherin-dependent neuronal adhesion, causing neuronal aggregation. PMID: 28174271
    6. N-cadherin has different effects on osteolineage cells depending upon their differentiation stage. PMID: 28240364
    7. Migration of bone marrow-mesenchymal stem cells in response to TGF-beta was mediated through N-cadherin and noncanonical TGF-beta signals. PMID: 28213973
    8. The dependence of migration of the fiber cell apical domains along the Epithelial Fiber Interface for lens morphogenesis on N-cadherin provides new insight into the process of tissue development. PMID: 28552735
    9. in chicken and mouse embryos, PAPC expression is tightly regulated by the clock and wavefront system in the posterior PSM and exhibits a striking complementary pattern to N-cadherin PMID: 28087631
    10. Loss of N-cadherin in the context of oncogenic K-ras leads to increased pancreatic intraepithelial neoplasia (PanIN) incidence and progression. PMID: 26477318
    11. Type I collagen was highly expressed in the spinal cord during the scar-forming phase and induced astrocytic scar formation via the integrin-N-cadherin pathway. PMID: 28628111
    12. N-cadherin-null enteric neural crest cells do not respond to C3a co-attraction. C3a regulates cell migration in a N-cadherin-dependent process. PMID: 27041467
    13. Knock-down of ZBED6 in insulin-producing cells promotes N-cadherin junctions between beta-cells and neural crest stem cells in vitro. PMID: 26750727
    14. Knockdown of N-cadherin in 3T3 fibroblasts did not impede gap closure in a soft tissue wound healing model. PMID: 26980715
    15. Specific deletion of Cdh2 in Sertoli cells leads to altered meiotic progression and subfertility of mice. PMID: 25631347
    16. CRP suppresses expression of N-cadherin (p < 0.01), a mesenchymal marker of EMT, and ZEB-1, an EMT-related transcription factor (p < 0.01). These findings suggest that CRP inhibits EMT in a MCA-38 tumor-bearing mouse model. PMID: 25864110
    17. these studies suggest that N-cadherin may represent a viable therapeutic target to prevent the dissemination of MM PCs and delay MM disease progression. PMID: 26194766
    18. N-cadherin is required for the establishment and maintenance of anterior heart field -cardiac progenitor cells. PMID: 25367124
    19. delta-Catenin Regulates Spine Architecture via Cadherin and PDZ-dependent Interactions. PMID: 25724647
    20. N-cadherin is not essential for healthy enamel development and does not significantly affect the mineralization process. PMID: 25014356
    21. Fbxo45 binds to N-cadherin intracellularly and prevents its degradation thereby playing a key role in promoting N-cadherin-mediated neuronal differentiation. PMID: 25143387
    22. Microtubules are directed towards N-cadherin-mediated contacts by their plus ends and are involved in a negative-feedback loop with the formation of cell-cell contacts in myogenic cells. PMID: 24522194
    23. NELL2 plays an important role in the regulation of neuronal differentiation via control of N-cadherin expression and cell aggregation. PMID: 24465772
    24. This study showed that the adherens junction proteins afadin and CDH2 are critical for the control of cell proliferation in the dorsal telencephalon and for the formation of its normal laminar structure. Inactivation. PMID: 25100583
    25. activation of calpains disassembles cell-cell adhesion at intercalated discs by degrading N-cadherin and thereby promotes left ventricular remodeling after myocardial infarction. PMID: 24891510
    26. This study provides evidence that co-application of GDNF and estradiol exert important protective effects on dopaminergic neurons by increasing the interaction between ERalpha and N-cadherin. PMID: 24254198
    27. In senescent osteopenic mice, blocking the CADH2-Wnt interaction using an antagonist peptide increased Wnt5a and Wnt10b expression, bone formation, and bone mass. PMID: 24664975
    28. These findings suggest N-cadherin/FGFR has a pivotal role in promoting metastasis through differential regulation of ERK and AKT, and underscore the potential for targeting the FGFR in advanced ErbB2-amplified breast tumors. PMID: 23975425
    29. N-cadherin regulates osteogenesis and migration of bone marrow-derived mesenchymal stem cells. PMID: 23187741
    30. N-cadherin regulates beta-catenin signaling through both Wnt and AKT. PMID: 23618343
    31. Peptide-mediated disruption of N-cadherin-LRP5/6 interaction increases Wnt/beta-catenin signaling and osteoblast function in vitro and promotes calvaria bone formation in vivo. PMID: 22576936
    32. Stability studies of extracellular domain two of neural-cadherin. PMID: 21843662
    33. Lowering N-cadherin expression in pancreatic ductal adenocarcinoma improves survival. PMID: 22158044
    34. a role for N-cadherin in the formation of fibrosis and cysts in the mammary gland PMID: 22030022
    35. The integration of three different classes of cytoskeletal systems found in the synaptic N-cadherin complex may imply a dynamic switching of adhesive scaffolds in response to synaptic activity PMID: 22609377
    36. Galectin-3 protein regulates mobility of N-cadherin and GM1 ganglioside at cell-cell junctions of mammary carcinoma cells. PMID: 22846995
    37. The slow disassembly kinetics in the apo-state in wild-type N-cadherin does not originate from the differences in the X-interface residues. PMID: 22544613
    38. N-cadherin expression was efficiently ablated in osteoblast lineage cells. Basal hematopoiesis, HSC number, cell cycle status, long-term repopulating activity, and self-renewal capacity were normal. PMID: 22323481
    39. Targeted deletion of N-cadherin resulted in an age-dependent bone phenotype, characterized by decreased mineralized bone, but no difference in steady-state HSC numbers or function at any time tested, and normal recovery from myeloablative injury. PMID: 22596259
    40. observed reduced N-cadherin expression in RB1(-/-) calvarial osteoblasts PMID: 22547682
    41. Smad2/3 signaling in ECs is indispensable for maintenance of vascular integrity via the fine-tuning of N-cadherin, VE-cadherin, and S1PR1 expressions in the vasculature. PMID: 22498737
    42. The Nox1 NADPH oxidase signals through EGFR to activate MMP-9 and promote the shedding of N-cadherin, thereby contributing to smooth muscle cell migration. PMID: 22102727
    43. Cadherin Cdh2 (Ncad) and the calcium receptor Casr show higher gene expression and variability only in etal bone marrow at 17.5 days post coitum (dpc). PMID: 22276210
    44. The data showed that N-cadherin is not essential for enteric nervous system development but it does modulate the modes of enteric neural crest cell migration and acts in concert with beta1-integrin to control the development of the enteric nervous system. PMID: 22342243
    45. We conclude that VE and N-cadherin have both additive and divergent effects on Endothelial cells (ECs). PMID: 22246030
    46. Data show that N-cadherin mediated junctions between osteoblasts are needed for osteoblast gene transcription, and mediate osteogenesis through PI3K signaling. PMID: 21964322
    47. these data provide evidence that Shroom3 and N-cadherin function cooperatively downstream of Pitx2 to directly regulate cell shape changes necessary for early gut tube morphogenesis. PMID: 21726547
    48. The structural integrity of the myocardial cell wall was compromised in the N-cadherin mutant embryos, leading to a malformed heart and a delay in embryonic development. PMID: 21680756
    49. Data show that Rap1 regulated the plasma membrane localization of NCad and NCad rescued radial polarization when Rap1 was inhibited. PMID: 21516100
    50. cortactin was required for N-cadherin-mediated enhancement of Kv1.5 channel activity PMID: 21507952

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  • 亚细胞定位：
    Cell membrane; Single-pass type I membrane protein. Cell membrane, sarcolemma. Cell junction. Cell surface.
  • 组织特异性：
    Expressed in cardiac muscle (at protein level).
  • 数据库链接：

    KEGG: mmu:12558

    STRING: 10090.ENSMUSP00000025166

    UniGene: Mm.257437