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  4. Recombinant Mouse CD70 antigen (Cd70)

Recombinant Mouse CD70 antigen (Cd70)

  • 货号：
    CSB-CF004954MO
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
  • Uniprot No.：
  • 别名：
    Cd70; Cd27l; Cd27lg; Tnfsf7; CD70 antigen; CD27 ligand; CD27-L; Tumor necrosis factor ligand superfamily member 7; CD antigen CD70
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-195
  • 氨基酸序列
    MPEEGRPCPWVRWSGTAFQRQWPWLLLVVFITVFCCWFHCSGLLSKQQQRLLEHPEPHTAELQLNLTVPRKDPTLRWGAGPALGRSFTHGPELEEGHLRIHQDGLYRLHIQVTLANCSSPGSTLQHRATLAVGICSPAAHGISLLRGRFGQDCTVALQRLTYLVHGDVLCTNLTLPLLPSRNADETFFGVQWICP
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Cytokine which is the ligand for CD27. The CD70-CD27 pathway plays an important role in the generation and maintenance of T cell immunity, in particular during antiviral responses. Upon CD27 binding, induces the proliferation of costimulated T-cells and enhances the generation of cytolytic T-cells.
  • 基因功能参考文献：
    1. CD70 mitigates atherosclerosis at least in part by modulating macrophage function. PMID: 27786334
    2. these findings demonstrate for the first time, to our knowledge, that T cell-derived CD70 plays a novel immune checkpoint role in inhibiting inflammatory T cell responses PMID: 29046346
    3. findings demonstrate that host CD70 serves as a unique negative regulator of allogeneic T cell response by contributing to donor T cell apoptosis and inhibiting expansion of donor effector T cells. PMID: 28550198
    4. Mice lacking CD70 did not accumulate memory T cells and did not develop hypertension. PMID: 26988069
    5. find that while stimulation of CD27 in isolation drives weak Eomesodermin(hi) T-bet(lo) CD8(+) T-cell responses to OVA immunization PMID: 26461455
    6. Data show that although CD70 is required for the activation of the antiviral adaptive response, it has a regulatory role in early cytokine responses to viruses such as MCMV, possibly through maintenance of Treg survival and function. PMID: 24913981
    7. the ability of CD70 to trigger costimulation is self-regulated when it binds its complementary receptor. PMID: 23913967
    8. Expression of CD70 by B cells aggravates experimental autoimmune encephalomyelitis by reducing the number of regulatory T cells. PMID: 23137837
    9. CD70-deficient mice infected with lymphocytic choriomeningitis virus produced only half as many T8 cells. Viral clearance was substantially delayed. CD70-mediated costimulation is not required for secondary or T4 responses. PMID: 23269247
    10. Although CD70 is required for dendritic cell-mediated delay of T cell tolerance induction, CD80 and CD86 are necessary for refunctionalizing the tolerized T cells in prostate tumor tissue PMID: 22798683
    11. CD70-driven costimulation induces survival or Fas-mediated apoptosis of T cells depending on antigenic load. PMID: 22450812
    12. Adoptively transferred CD70-specific T cells induced sustained regression of established murine xenografts. PMID: 21304103
    13. In this review, CD27 and CD70 constitute a unique ligand/receptor pair which can activate innate and adaptive immunity as well as regulate immunity versus tolerance. PMID: 20699361
    14. We show here that sterile chronic immune activation driven by enhanced expression of CD70 is in fact highly protective against atherosclerosis. PMID: 20505312
    15. Data show that costimulation by CD70 or OX40L seems to be necessary for primary CD4(+) T cell responses to multiple forms of immunization. PMID: 20639485
    16. These data support the hypothesis that induction of CD70 expression on dendritic cells (DC) after an encounter with activated CD4(+) T cells is a major component of CD4(+) T cell-mediated licensing of DC. PMID: 19952354
    17. Data indicate that, while CD70 plasma membrane expression is not detectable in resting T and B cells, low levels are induced following influenza infection in lung-infiltrating activated T cells and T and B cells in draining lymph nodes. PMID: 12496380
    18. Administration of antigenic peptide and a soluble recombinant form of CD70 results in a massive (>300-fold) expansion of antigen-specific CD8+ T cells in vivo, due to the enhanced proliferation and survival of activated T cells. PMID: 15128787
    19. CD70 expression on antigen presenting cells plays a key role in CD40-dependent CD8 T cell responses; CD70 blockade inhibits CD40-mediated clonal expansion of CD8 T cells and reduces the number of memory CD8 T cells generated. PMID: 15557144
    20. Expression of CD70 on dendritic cells is an important determinant for helper-dependence of primary CD8+ T cell expansion. PMID: 15634890
    21. The novel CD70-CD27 pathway plays a critical role in alloimmune responses independently of the CD28-B7 costimulatory pathway. PMID: 15661893
    22. CD70-positive antigen-presenting cells control the proliferation and differentiation of T cells in the intestinal mucosa. PMID: 15937486
    23. ectopic expression of CD70 in mouse glioma cells enhances apoptosis of T, B and NK cells in coculture, but nevertheless promotes glioma cell lysis by NK cells in vitro PMID: 16217761
    24. innate and adaptive (CD4+ T cells) arms of the immune system use a common signaling pathway in driving CD8+ T cell responses and suggest that expression of CD70 on dendritic cell (DC) represents the hallmark of conditioned DC PMID: 16920932
    25. CD70 expression on dendritic cells plays an important role in the priming of CD8-positive T cells by pathogens. PMID: 17295392
    26. CD70 is a decision maker for Th1 differentiation by CD205(+) dendritic cells. PMID: 17438065
    27. CD27-CD27L interactions are essential for developing a robust primary antiviral CD8-positive T cell immune response. PMID: 18292513
    28. injection of alpha-galactosylceramide triggers CD70 expression on splenic T cell zone dendritic cells and that this is dependent on CD40 signaling. PMID: 18354184
    29. the sole expression of CD70 by otherwise immature cDCs sufficed to convert CD8+ T cell tolerance into immunity, defining the importance of CD27-CD70 interactions at the interface between T cell and DC. PMID: 19062317
    30. The CD27-CD70 costimulatory pathway plays an important role in the development of experimental colitis; CD70 blockade leads directly to reduction in T cell numbers and thus reduces mucosal inflammation. PMID: 19525396
    31. CD27L requires trimer stabilization and oligomerization PMID: 19596991
    32. endogenous IL-18 might facilitate stomach cancer cell immune escape by suppressing CD70 and increasing metastatic ability by upregulating CD44 and VEGF PMID: 19638429

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  • 亚细胞定位：
    Membrane; Single-pass type II membrane protein.
  • 蛋白家族：
    Tumor necrosis factor family
  • 组织特异性：
    Very low level of expression. Detected in splenocytes and thymocytes.
  • 数据库链接：

    KEGG: mmu:21948

    STRING: 10090.ENSMUSP00000019633

    UniGene: Mm.42228