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  4. Recombinant Mouse C3a anaphylatoxin chemotactic receptor (C3ar1)

Recombinant Mouse C3a anaphylatoxin chemotactic receptor (C3ar1)

  • 货号：
    CSB-CF003889MO
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
  • Uniprot No.：
  • 别名：
    C3ar1; C3r1; C3a anaphylatoxin chemotactic receptor; C3AR; C3a-R; Complement component 3a receptor 1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-477
  • 氨基酸序列
    MESFDADTNSTDLHSRPLFQPQDIASMVILGLTCLLGLLGNGLVLWVAGVKMKTTVNTVW FLHLTLADFLCCLSLPFSLAHLILQGHWPYGLFLCKLIPSIIILNMFASVFLLTAISLDR CLIVHKPIWCQNHRNVRTAFAICGCVWVVAFVMCVPVFVYRDLFIMDNRSICRYNFDSSR SYDYWDYVYKLSLPESNSTDNSTAQLTGHMNDRSAPSSVQARDYFWTVTTALQSQPFLTS PEDSFSLDSANQQPHYGGKPPNVLTAAVPSGFPVEDRKSNTLNADAFLSAHTELFPTASS GHLYPYDFQGDYVDQFTYDNHVPTPLMAITITRLVVGFLVPFFIMVICYSLIVFRMRKTN FTKSRNKTFRVAVAVVTVFFICWTPYHLVGVLLLITDPESSLGEAVMSWDHMSIALASAN SCFNPFLYALLGKDFRKKARQSIKGILEAAFSEELTHSTNCTQDKASSKRNNMSTDV
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Receptor for the chemotactic and inflammatory peptide anaphylatoxin C3a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production.
  • 基因功能参考文献：
    1. Development of burn-induced mechanical allodynia, thermal allodynia, weight bearing changes and edema was assessed in C3aR(-/-), C5aR1(-/-) and C5aR2(-/-) mice and compared to their wild type controls over three days. Burn-induced mechanical allodynia, thermal allodynia and weight bearing changes developed normally C3aR(-/-), C5aR1(-/-) and C5aR2(-/-) mice. PMID: 29274925
    2. Complement component 3a receptor 1 role in the lung cancer progression. PMID: 29118090
    3. The complement 3a receptor (C3aR1) participates in microglial signaling under pathological conditions and was recently shown to be activated by the neuropeptide TLQP-21. PMID: 28850719
    4. whilst the C3aR modulates some elements of disease pathogenesis, overall it is not critical in effector responses and glomerular injury caused by autoimmunity to MPO PMID: 29315316
    5. study provided detailed insights into the C3aR expression pattern in immune and stromal cells under steady-state conditions PMID: 28626064
    6. proposal that C3aR activation alters the tumor inflammatory milieu, thereby promoting tumor growth PMID: 27183625
    7. increased circulating lipopolysaccharide induces upregulation of complement C3a receptor on neutrophils and activation of the complement cascade. PMID: 26996437
    8. showed that C3a receptor/C5a receptor-deficient mice developed much less severe uveitis than did control mice using all retinal examination methods PMID: 26394814
    9. these findings suggest a critical role for C3a through autocrine/paracrine induction of C3aR in the pathogenesis of cigarette smoke-induced sterile inflammation and provide new therapeutic targets for the treatment of emphysema. PMID: 25465103
    10. C3a/C3aR signaling during host immune response suppresses Fas expression and caspase-3 activity while increasing Bcl-2 proto-oncogene protein expression, providing protection to myeloid and lymphoid cells against L. monocytogenes-induced apoptosis. PMID: 24981453
    11. This study indicated that C3a and C5a-mediated functions are not critical to the development of experimental autoimmune uveitis. PMID: 24035596
    12. The binding of TLQP-21 to C3AR1 not only has effects on signaling but also modulates cellular functions PMID: 23940034
    13. C3a receptor promotes viral containment in mice inoculated with vaccinia virus at sites of allergic skin inflammation. PMID: 23684067
    14. The role of the anaphylatoxin C3a receptor in acute dextran sulfate sodium-induced colitis in mice, was investigated. PMID: 23638016
    15. The receptor for complement component C3a mediates protection from intestinal ischemia-reperfusion injuries by inhibiting neutrophil mobilization. PMID: 23696668
    16. nT reg cells express C3aR and C5aR, and signaling through these receptors inhibits nT reg cell function. PMID: 23382542
    17. Absence of signaling into CD4 cells via C3aR and C5aR enables autoinductive TGF-beta1 signaling and induction of Foxp3+ regulatory T cells. PMID: 23263555
    18. Complement C3a receptor activation contributes to the pathogenesis of preeclampsia. PMID: 22868393
    19. Clinical disease activity in C3aR(-/-), C5aR(-/-), and C6-deficient (C6-def) mice was decreased by 52, 94, and 65%, respectively, as compared with wild-type mice. PMID: 22205026
    20. might participate in conjunction with other complement effector functions down-stream of C3/C3b in the protection of Th2 induced allergic contact dermatitis PMID: 22151392
    21. distinct roles of C3a and C5a receptor signaling in complement-induced tubulointerstitial injury PMID: 21677637
    22. These results confirm an important role for C5 cleavage in murine MI/R injury. PMID: 20930931
    23. C3a plays an important role in CNS lupus, signaling through its receptor C3aR. PMID: 19900981
    24. It remains unclear how the changes in these disease parameters contribute to the loss of the protective effect seen in C3aR(-/-) mice, however our data indicate a level of cross-modulation between the C3aR and C5aR during EAE. PMID: 19850104
    25. This increased expression at late time points after occlusion is most likely the result of massive infiltration of leukocytes expressing the receptors. PMID: 11948810
    26. The complement anaphylatoxin C3a receptor plays a novel regulatory role in the development of Th2 responses in a mouse model of pulmonary allergy. PMID: 12421977
    27. The C3a-C3aR axis may prevent an uncontrolled release of hematopoietic stem cells into peripheral blood from bone marrow PMID: 14604969
    28. C3a receptor mRNA is expressed in murine cortical and glomerular epithelium and renal medulla. PMID: 15356170
    29. Deletion of the C3a receptor is protective in myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis in C57BL/6 mice. PMID: 15383607
    30. Data demonstrate that independently of antibody production, absence of complement C3a anaphylatoxin receptor causes enhanced killing of Pseudomonas aeruginosa despite a diminished inflammatory response in a mouse model of pneumonia. PMID: 16461429
    31. These results indicate that C5 plays a crucial role in modulating the enhanced-respiratory syncytial virus disease phenotype, by affecting expression of C3aR in the lungs. PMID: 17079327
    32. engagement of C3aR on the surface of dendritic cells leads to alterations in the level of intracellular cAMP. C3aR activation-induced depression of cAMP was associated with enhanced capacity of DCs for antigen uptake and T-cell stimulation PMID: 18812470
    33. Activation of the C3aR plays a protective, not pathologic, role in the early phase of inflammatory nephritis in the MRL/lpr model of systemic lupus erythematosus. PMID: 19167760
    34. C3aR in macrophages, and potentially adipocytes, plays an important role in adipose tissue homeostasis and insulin resistance PMID: 19581423

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 1 family
  • 组织特异性：
    Detected in varying levels in all tissues examined except the spleen. Especially abundant in heart and lung.
  • 数据库链接：

    KEGG: mmu:12267

    STRING: 10090.ENSMUSP00000048092

    UniGene: Mm.2408