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  4. Recombinant Mouse Bcl-2-like protein 1 (Bcl2l1)

Recombinant Mouse Bcl-2-like protein 1 (Bcl2l1)

  • 货号：
    CSB-CF731050MO
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
  • Uniprot No.：
  • 别名：
    Bcl2l1; Bcl2l; Bclx; Bcl-2-like protein 1; Bcl2-L-1; Apoptosis regulator Bcl-X
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-233
  • 氨基酸序列
    MSQSNRELVVDFLSYKLSQKGYSWSQFSDVEENRTEAPEETEAERETPSAINGNPSWHLA DSPAVNGATGHSSSLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITPGTAY QSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIASWMATYLNDHLEP WIQENGGWDTFVDLYGNNAAAESRKGQERFNRWFLTGMTVAGVVLLGSLFSRK
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.; Isoform Bcl-X(L) also regulates presynaptic plasticity, including neurotransmitter release and recovery, number of axonal mitochondria as well as size and number of synaptic vesicle clusters. During synaptic stimulation, increases ATP availability from mitochondria through regulation of mitochondrial membrane ATP synthase F(1)F(0) activity and regulates endocytic vesicle retrieval in hippocampal neurons through association with DMN1L and stimulation of its GTPase activity in synaptic vesicles. May attenuate inflammation impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release.; Isoform Bcl-X(S) promotes apoptosis.
  • 基因功能参考文献：
    1. Depletion of miR-34a facilitated endothelial cell growth and blocked apoptosis in AS by upregulating Bcl-2, offering a promising avenue for AS therapy. PMID: 29704100
    2. BCL-XL promotes stemness and contributes to the aggressiveness of both melanoma and glioblastoma. PMID: 29238043
    3. targeting BCLxL in human and mouse synovial sarcoma with the small molecule BH3 domain inhibitor, BXI-72, achieved significant cytoreduction and increased apoptotic signaling. PMID: 28851813
    4. GATA-3 participates in the healing of bone fractures via regulating bcl-xL gene expression, owing to its association with Runx2. PMID: 29170477
    5. this study demonstrates that necrosis of Mycobacterium tuberculosis-infected macrophages is dependent on the action of Bcl-xl PMID: 28401933
    6. Mitochondrial Bcl-xL is involved in maintaining mitochondrial respiratory capacity. Its deficiency causes oxidative stress, which is associated with an increased glycolytic capacity and balanced by an increased activity of the pentose phosphate pathway. PMID: 28807815
    7. Proapoptotic proteins BIM and PUMA are not critical for the reticulocyte apoptosis caused by loss of the pro-survival protein BCL-XL. PMID: 28682312
    8. BMP4 promotes survival of neural stem/progenitor cells by enhancing the anti-apoptotic function of Bcl-xL via BMP4-Smad1/5/8-Id1 signaling in the presence of FGF-2. PMID: 29353044
    9. Bcl-xL is required for survival of post mitotic neurons throughout the developing spinal cord. PMID: 27665712
    10. Atherosclerosis-associated endothelial cell apoptosis may partially result from downregulation of Bcl-Xl, through upregulation of miR-876 that binds and suppresses translation of Bcl-Xl mRNA. PMID: 28723693
    11. Bcl-xL is a driver in colorectal tumorigenesis and cancer progression. PMID: 27537525
    12. These data show that Mcl-1 is dispensable for the regulation of apoptosis during infection with different large DNA viruses.Bcl-XL, on the other hand, can be important to maintain survival of virus-infected cells PMID: 27537523
    13. BCL-XL expression promotes survival of immature B cells, expression of BCL-2 is important for survival of mature B cells and long-lived plasma cells (PC), and expression of MCL-1 is important for survival throughout B-cell development. PMID: 27560714
    14. Bcl-xL deficiency induced apoptosis in a select population of differentiated neurons and led to severe neurobehavioral abnormalities. PMID: 27194326
    15. loss of PUMA had no impact on the loss of platelets caused by loss of BCL-XL. It therefore remains to be established whether other BH3-only proteins play a critical role in induction of apoptosis in platelets or whether their death is controlled solely by the interactions between BCL-XL with BAK and BAX. PMID: 27221652
    16. MLF1 is negatively regulated by 14-3-3 via binding to, and blocking, MLF1's Bcl-2 homology domain 3 and thereby preventing Bcl-XL from associating with MLF1. PMID: 26563351
    17. Genetic and pharmacological inhibition of BCL-W and BCL-XL causes directed elimination of senescent cells. PMID: 27048913
    18. Valproic acid sensitized TRAIL-resistant papillary thyroid carcinoma cells to apoptotic cell death through involvement of Nrf2 and Bcl-xL. PMID: 26721202
    19. These findings indicate that eosinophil survival is largely regulated by betac chain-induced NF-kappaB activation and subsequent induction of Bcl-x PMID: 25862560
    20. these data indicate that beta-cell apoptosis is, in part, attributable to the modulation of 5'SS selection in the Bcl-x pre-mRNA by bioactive lipids modulated by iPLA2beta. PMID: 25762722
    21. only loss of both Bclx alleles markedly forestalled tumorigenesis, loss of a single Bim allele overcame this blockade. PMID: 24858047
    22. analysis of the role of BCL-XL or MCL-1 in the development and sustained growth of thymic lymphoma elicited by loss of p53 reveals that only MCL-1 is critical PMID: 25368374
    23. cell death is C/EBP homologous protein (CHOP)-dependent, connecting these events to the UPR. Thus plasma cell differentiation proceeds through a Bcl-xL-dependent intermediate. PMID: 25023286
    24. These results demonstrate that Bcl-xL regulates CD1d-mediated Ag processing and presentation to NKT cells by altering the late endosomal compartment and changing the intracellular localization of CD1d. PMID: 25070854
    25. anti-apoptotic role of HAX-1 versus BCL-XL in cytokine-dependent bone marrow-derived cells PMID: 24910348
    26. IL-33/ST2 axis promotes mast cell survival via BCLXL. PMID: 24982172
    27. PP6 activity is regulated to control apoptosis by modulating Ser(62) phosphorylation of Bcl-xL, which results in its polyubiquitination and degradation. PMID: 24808369
    28. signaling cassette identified in cardiac myocytes consisting of K-Ras, RASSF1A and Mst1 localized to mitochondria; promotes Mst1 activation in response to oxidative stress; activated Mst1 phosphorylates Bcl-xL antagonizing Bcl-xL-Bax binding causing activation of Bax and subsequent apoptosis PMID: 24813943
    29. A double-mutant knockin of the CD28 YMNM and PYAP motifs reveals a critical role for the YMNM motif in regulation of T cell proliferation and Bcl-xL expression. PMID: 24639356
    30. Instead, Bcl-xL -blocked apoptosis resulting from hypoxia and/or nutrient loss associated with the inhibition of angiogenesis caused by NK cell-secreted IFN-gamma PMID: 24313893
    31. identified inositol trisphosphate receptors as unique effectors of K-Ras4B that antagonize the prosurvival signals of other K-Ras effectors. PMID: 24297914
    32. Disruption of Bcl-xL:Bax binding caused rapid apoptosis of neural progenitors and medulloblastoma cells. PMID: 24227720
    33. Bcl-xL interacts functionally with VDAC1 and -3 but not VDAC2. PMID: 23720737
    34. Cleavage-resistant Bcl-2 and Bcl-xL are more efficient than their wild-type counterparts at inhibiting apoptosis in primary mouse T cells after T cell receptor cross-linking mechanisms. PMID: 23203923
    35. In steatotic hepatocytes, the lack of voltage-dependent anion channel phosphorylation is accompanied by a decrease of interaction with the serine/threonine glycogen synthase kinase 3 and Bcl-XL in mitochondria. PMID: 22814966
    36. Bcl-xL has crucial anti-apoptotic roles at multistages in the megakaryocytic lineage, making possible prevention of lethal or severe spontaneous hemorrhage. PMID: 22790873
    37. Hesperetin prevented the xenograft growth by down-regulating the expression of cyclin D1, CDK4 and Bcl-xL and up-regulating p57Kip2 expression in MCF-7 cells. PMID: 22209285
    38. Clusterin interacts with Bcl-xL in dying hippocampal CA3 neurons following seizures while the levels of Bcl-xL remain constant. PMID: 22197644
    39. BCL-X is required for survival of differentiating retinal ganglion cells. PMID: 22836101
    40. when localalized in the endoplasmic reticulum, Bcl-x(L) impinges on Ca(2+) homeostasis but does not affect apoptosis unless Bcl-x(L) is present in additional cellular compartments. PMID: 22573883
    41. Tanshinone IIA protected neurons against the Abeta-induced cytotoxicity most likely via activation of the Bcl-xL pathway PMID: 22498308
    42. The combination of Bcl-x(L) and Mcl-1 is essential for the viability of the megakaryocyte lineage. PMID: 22374700
    43. Modulation of macrophage resistance to apoptosis through targeted deletion of Bcl-x has a major impact on the entire macrophage cell population in the body PMID: 22383704
    44. The Bcl-2 proteins Noxa and Bcl-xL co-ordinately regulate oxidative stress-induced apoptosis. PMID: 22380599
    45. Pathologic elevation of Bcl-x(L) may be the result of impaired adaptation, with implications for myeloproliferative disease mechanisms. PMID: 22086418
    46. Data show that Down syndrome model mice ehxibit downregulation of Bcl-X(L) in the hippocampus. PMID: 21684326
    47. Hematopoietic stem cells in patients with an Lnk/Sh2b3 mutation might become resistant to apoptosis due to thrombopoietin-mediated enhanced expression of Bcl-xL. PMID: 22101255
    48. Bcl-xL is required for lymphomagenesis in myc(-/-) transgenic mice, who constitutively overexpress c-Myc oncoprotein in B-lymphoid cells and develop pre-B and B-cell lymphomas; this is in contrast to Bcl-2 which is required. PMID: 21998213
    49. EVI1 directly induces the expression of Bcl-xL through the first set of zinc finger and thereby inhibits apoptosis PMID: 21980434
    50. Hrk deficiency does not significantly attenuate the widespread apoptosis seen in the Bcl-x (-/-) embryonic nervous system, indicating that other BH3-only molecules, alone or in combination, may regulate BAX activation in immature neurons. PMID: 22043021

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  • 亚细胞定位：
    Mitochondrion membrane; Single-pass membrane protein. Nucleus membrane; Single-pass membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.; [Isoform Bcl-X(delta-TM)]: Cytoplasm.
  • 蛋白家族：
    Bcl-2 family
  • 组织特异性：
    Widely expressed, with highest levels in the brain, thymus, bone marrow, and kidney. Bcl-X(L) and Bcl-X(delta-TM) expression is enhanced in B- and T-lymphocytes that have been activated.
  • 数据库链接：

    KEGG: mmu:12048

    STRING: 10090.ENSMUSP00000007803

    UniGene: Mm.238213