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  4. Recombinant Mouse BDNF/NT-3 growth factors receptor (Ntrk2)

Recombinant Mouse BDNF/NT-3 growth factors receptor (Ntrk2)

  • 货号：
    CSB-CF016134MO
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
  • Uniprot No.：
  • 别名：
    Ntrk2; Trkb; BDNF/NT-3 growth factors receptor; GP145-TrkB/GP95-TrkB; Trk-B; Neurotrophic tyrosine kinase receptor type 2; TrkB tyrosine kinase
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    32-821
  • 氨基酸序列
    CPTSCKCSSARIWCTEPSPGIVAFPRLEPNSVDPENITEILIANQKRLEIINEDDVEAYVGLRNLTIVDSGLKFVAYKAFLKNSNLRHINFTRNKLTSLSRRHFRHLDLSDLILTGNPFTCSCDIMWLKTLQETKSSPDTQDLYCLNESSKNMPLANLQIPNCGLPSARLAAPNLTVEEGKSVTLSCSVGGDPLPTLYWDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHHWCIPFTVRGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLMAKNEYGKDERQISAHFMGRPGVDYETNPNYPEVLYEDWTTPTDIGDTTNKSNEIPSTDVADQSNREHLSVYAVVVIASVVGFCLLVMLLLLKLARHSKFGMKGPASVISNDDDSASPLHHISNGSNTPSSSEGGPDAVIIGMTKIPVIENPQYFGITNSQLKPDTFVQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCPQEVYELMLGCWQREPHTRKNIKSIHTLLQNLAKASPVYLDILG
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Receptor tyrosine kinase involved in the development and the maturation of the central and the peripheral nervous systems through regulation of neuron survival, proliferation, migration, differentiation, and synapse formation and plasticity. Receptor for BDNF/brain-derived neurotrophic factor and NTF4/neurotrophin-4. Alternatively can also bind NTF3/neurotrophin-3 which is less efficient in activating the receptor but regulates neuron survival through NTRK2. Upon ligand-binding, undergoes homodimerization, autophosphorylation and activation. Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades. Through SHC1, FRS2, SH2B1, SH2B2 activates the GRB2-Ras-MAPK cascade that regulates for instance neuronal differentiation including neurite outgrowth. Through the same effectors controls the Ras-PI3 kinase-AKT1 signaling cascade that mainly regulates growth and survival. Through PLCG1 and the downstream protein kinase C-regulated pathways controls synaptic plasticity. Thereby, plays a role in learning and memory by regulating both short term synaptic function and long-term potentiation. PLCG1 also leads to NF-Kappa-B activation and the transcription of genes involved in cell survival. Hence, it is able to suppress anoikis, the apoptosis resulting from loss of cell-matrix interactions. Isoform GP95-TRKB may also play a role in neutrophin-dependent calcium signaling in glial cells and mediate communication between neurons and glia.
  • 基因功能参考文献：
    1. Low TRKB Expression is associated with social dominance. PMID: 30282736
    2. We report here on the incorporation of a BDNF mimetic sequence into a supramolecular peptide amphiphile filamentous nanostructure capable of activating the BDNF receptor TrkB and downstream signaling in primary cortical neurons in vitro. PMID: 30211565
    3. Data suggest that neurotrophic tyrosine receptor kinase type 2 (TrkB)-dependent neuronal differentiation is involved in the sustained antidepressant effects of ketamine. PMID: 29162814
    4. increased BDNF-TrkB signaling and synaptogenesis in the nucleus accumbens by deletion of alpha7 nAChR plays a key role in depression PMID: 27821848
    5. The changes in the expression patterns of proBDNF, BDNF, and their receptors under the influence of chronic alcohol consumption in the depressive ASC strain and nondepressive CBA strain mice are different. PMID: 28900083
    6. A critical period of susceptibility to cigarette smoke exposure exists in the prenatal and early postnatal period, which results a downregulation in brain-derived neurotrophic factor/tyrosine kinase receptor B signaling in the hippocampus and enhances depression-like behaviors later in life. PMID: 26503133
    7. Ventral hippocampal trkB is essential to goal-directed action selection, countering habit-based behavior otherwise facilitated by developmental stress hormone exposure. PMID: 29186135
    8. BDNF acts retrogradely on TrkB in climbing fibers , and facilitates elimination of climbing fibers synapses from Purkinje cells somata during the third postnatal week. PMID: 28775326
    9. The three receptor sets considered (mAChR, AR and TrkB receptors) intervene in modulating the conditions of the competition between nerve endings. PMID: 27339059
    10. Signaling through postsynaptic trkB receptors is considered to be an essential part of a cellular mechanism for maintaining the contacts of some, but not all, synaptic contacts onto motoneurons PMID: 27433358
    11. findings show that BDNF-TrkB signaling, rather than Dopamine signaling, in the Ventral Tegmental Area -Nuc. Accumbens circuit is crucial for facilitating depressive-like depressive-like outcomes after Chronic Social Defeat Stress and they establish BDNF-TrkB signaling as a pathologic mechanism during periods of chronic stress. PMID: 26858215
    12. inhibition of Sig-1 R prevented cocaine-induced TrkB activation in hippocampal neurons. PMID: 27735948
    13. After spinal cord injury, astrocyte-specific TrkB knock-out mice showed reduced hyperpathic responses and improved motor coordination. PMID: 28270575
    14. Results imply that oleanolic acid ameliorates scopolamine-induced memory impairment by modulating the brain-derived neurotrophic factor -ERK1/2-cAMP response element-binding protein pathway through tropomyosin receptor kinase B activation in mice, suggesting that oleanolic acid would be a potential therapeutic agent for the treatment of cognitive deficits. PMID: 27470063
    15. Data show that c-Jun NH2-terminal kinase (JNK)-interacting protein-3 (JIP3) participates in the migration of cortical neurons during cortical development by mediating TrkB receptor axonal anterograde transport. PMID: 28259553
    16. findings reveal a spine-autonomous, autocrine signalling mechanism involving NMDAR-CaMKII-dependent BDNF release from stimulated dendritic spines and subsequent TrkB activation on these same spines that is crucial for structural and functional plasticity PMID: 27680698
    17. Following ethanol administration, phosphorylation of TrkB in the striatum was significantly reduced in wild-type mice. PMID: 26992697
    18. Results suggest that the therapeutic actions of atypical antidepressant drugs involve various neurocircuits, some of which, but not all, appears to involve BDNF/TrkB and downstream neuroplastic signaling PMID: 26653128
    19. Observations provide evidence that female-specific induction of estrogen receptor alpha expression confers neuroprotection with TrkB agonist therapy via Src family kinase activation and account for improved functional outcomes in female neonates post-hypoxia and ischemia. PMID: 26839918
    20. data suggest antidepressant effects of BDNF-TrkB in the NAc, which could not be explained by activation of the transcription factors CREB or beta-catenin. The effects TrkB has on depression-related behavior in different brain regions appear to critically depend on the targeted cell type. PMID: 26315459
    21. Study indicates that diminished mature BDNF trophic signaling through the TrkB receptor, rather than an induction in proBDNF, is a main contributing factor to the vulnerability of striatal neurons in the zQ175 HD mouse model PMID: 26282324
    22. TrkB is an endothelial injury-response molecule in atherogenesis. Endothelial brain-derived neurotrophic factor/TrkB signaling reduces VE-cadherin shedding and protects against atherosclerotic lesion development in ApoE-/- mice. PMID: 26431274
    23. Brain ischaemia induces shedding of a BDNF-scavenger ectodomain from TrkB receptors by excitotoxicity activation of metalloproteinases and gamma-secretases. PMID: 26712630
    24. Brain-derived neurotrophic factor (BDNF) and its specific receptor, tropomyosin-related kinase (TrkB), have a role the in pathophysiology of depression. PMID: 26506052
    25. Expression of the dominant-negative BDNF receptor TrkB receptor in the majority of pyramidal neurons in adult visual cortex has strikingly different effects on cortical wiring than expression of the same transgene in a sparse neuron population. PMID: 25316336
    26. The study provides further insight into the mechanisms of regulation of STEP61 and also offers a molecular basis for the Zn(2+)-induced sustained activation of ERK2. PMID: 26574547
    27. Glial TrkB signaling plays an important role in the early stage of neural protection after traumatic injury. PMID: 26476348
    28. Demonstrate that TrkB protects endothelial integrity during atherogenesis by promoting Ets1-mediated VE-cadherin expression and plays a previously unknown protective role in the development of coronary artery disease. PMID: 25633318
    29. activation of muscular TrkB by the BDNF mimetic, 7,8-dihydroxyflavone (7,8-DHF), is sufficient to protect the development of diet-induced obesity in female mice PMID: 25754472
    30. Ntrk2 plays a role in the pathologic remodeling of the spleen that accompanies chronic Leishmania donovani infection. PMID: 25710496
    31. SKF83959 produces antidepressant effects in a chronic social defeat stress model of depression through hippocampal BDNFB-TrkB pathway. PMID: 25522427
    32. loss of memory and hippocampal synaptic plasticity in Parkinson disease models via BDNF/TrkB pathway. PMID: 25560396
    33. Reduced TrkB does not affect beta-amyloidosis but exacerbates the manifestation of hippocampal mnemonic and signaling dysfunctions in early Alzheimer's disease. PMID: 25942043
    34. Report a novel signaling mechanism in the heart that is activated by BDNF and provide evidence for a global role of this neurotrophin in the homeostasis of the organism by signaling through different TrkB receptor isoforms. PMID: 26347138
    35. Slitrk5 modulates brain-derived neurotrophic factor (BDNF)-dependent biological responses through direct interaction with TrkB receptors. Under basal conditions, Slitrk5 interacts with a transsynaptic binding partner, protein tyrosine phosphatase delta. PMID: 26004511
    36. This study demonistrated that selective impairment in extinction consolidation in male but not female TrkBfl/+:PV-Cre mice. PMID: 25127683
    37. TrkB knockout mice display impaired cardiac contraction and relaxation, showing that BDNF/TrkB signaling acts constitutively to sustain in vivo myocardial performance. PMID: 25583515
    38. Data indicate an important role of TRKB receptor in the pathogenesis of mastocytosis. PMID: 25124786
    39. BDNF/TrkB signaling plays an important role in the NRG1-stimulated NR2B regulation. PMID: 25052836
    40. a novel role for the TrkB.T1 receptor in sleep expression and provide new insights into the relationship between Brain-derived neurotrophic factor, psychiatric illness, and sleep PMID: 25502751
    41. PTP1B is a novel physiological regulator of TrkB and enhanced BDNF/TrkB signaling may contribute to the beneficial metabolic effects of PTP1B deficiency PMID: 25288805
    42. SORLA-mediated trafficking of TrkB enhances the response of neurons to BDNF. PMID: 23977241
    43. TrkB signaling in D1 neurons regulates body weight by distinct mechanisms for chow and high fat diet and may be important for defending the body against the development of obesity and obesity-related disorders. PMID: 23512795
    44. These results suggest an important role for BDNF in regulating migration of TrkB-expressing pericytes/SMCs to promote cardiac blood vessel ensheathment and functional integrity during development. PMID: 24498100
    45. Taste neurons consist of both a large TrkB-receptor-dependent and a small TrkB-receptor-independent subpopulation. PMID: 24386206
    46. Hypoxia-inducible factor-1 directly regulated TrkB expression, and, in turn, TrkB activated Akt signaling in metastatic lung cancer cells. PMID: 24982195
    47. Gonadotropin surge promotes oocyte survival at the onset of reproductive cyclicity by inducing oocyte expression of NTRK2 full-length receptors that set in motion an AKT-mediated survival pathway PMID: 24877631
    48. Our findings suggested essential autocrine/paracrine roles of the BDNF/TrkB signaling system in choriocarcinoma invasion and metastasis. PMID: 24403258
    49. The data point to a set of behaviors and changes in gene expression following postnatal deletion of TrkB in the dorsal striatum distinct from those in other brain regions. PMID: 24369067
    50. ability of 5-HT to induce the production of ROS resulting in transactivation of both PDGFbeta and TrkB receptors PMID: 24086766

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  • 亚细胞定位：
    Cell membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein. Early endosome membrane. Cell projection, axon. Cell projection, dendrite. Cytoplasm, perinuclear region. Cell junction, synapse, postsynaptic density.
  • 蛋白家族：
    Protein kinase superfamily, Tyr protein kinase family, Insulin receptor subfamily
  • 组织特异性：
    Expressed in the brain, in neurons (at protein level). Detected in hippocampus (at protein level). Widely expressed in the central and peripheral nervous system. The different forms are differentially expressed in various cell types. Isoform GP95-TRKB is
  • 数据库链接：

    KEGG: mmu:18212

    STRING: 10090.ENSMUSP00000078757

    UniGene: Mm.130054