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  4. Recombinant Mouse Arachidonate 5-lipoxygenase-activating protein (Alox5ap)

Recombinant Mouse Arachidonate 5-lipoxygenase-activating protein (Alox5ap)

  • 货号：
    CSB-CF001625MO
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
  • Uniprot No.：
  • 别名：
    Alox5ap; Flap; Arachidonate 5-lipoxygenase-activating protein; FLAP; MK-886-binding protein
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-161
  • 氨基酸序列
    MDQEAVGNVVLLALVTLISVVQNAFFAHKVEHESKAHNGRSFQRTGTLAFERVYTANQNC VDAYPTFLVVLWTAGLLCSQVPAAFAGLMYLFVRQKYFVGYLGERTQSTPGYIFGKRIIL FLFLMSFAGILNHYLIFFFGSDFENYIRTVSTTISPLLLIP
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Required for leukotriene biosynthesis by ALOX5 (5-lipoxygenase). Anchors ALOX5 to the membrane. Binds arachidonic acid, and could play an essential role in the transfer of arachidonic acid to ALOX5. Binds to MK-886, a compound that blocks the biosynthesis of leukotrienes.
  • 基因功能参考文献：
    1. ALOX5AP Overexpression in Adipose Tissue Leads to LXA4 Production and Protection Against Diet-Induced Obesity and Insulin Resistance PMID: 27207555
    2. Data indicate that a single amino acid mutation was sufficient to reverse the speciation observed in wild type 5-Lipoxygenase activating protein (FLAP). PMID: 27129215
    3. BRP-7 potently suppresses leukotriene biosynthesis by interacting with FLAP in mouse peritonitis model. PMID: 24641614
    4. FLAP regulates phosphorylation of tau protein via modulating GSK-3beta activity. PMID: 24301651
    5. This study demonistrated that a a novel role for FLAP in the pathogenesis of anxiety-like behavior in mice. PMID: 23357209
    6. Deletion of myeloid cell FLAP markedly attenuates the proliferative response to vascular injury, while preserving endothelial integrity. PMID: 23250985
    7. A FLAP inhibitor given during critical window periods may prevent oxygen induced aberration of pulmonary alveolarization in a dose- and time-dependent manner. PMID: 21052705
    8. the 5-LO pathway emerges early during embryonic stem cell differentiation into cells of the myeloid lineage PMID: 19965960
    9. Adipose tissue from obese mice, compared with that from lean mice, exhibited increased 5-LO activating protein PMID: 20207999
    10. Data show that 5-lipoxygenase activity increases during senescence-like growth arrest via a p53/p21-dependent pathway in both human and mouse embryo fibroblasts. PMID: 15616590
    11. Altered 5-lipoxygenase is associated with obesity and bone traits PMID: 16200066
    12. This observation supports the hypothesis that 5-LO may be involved in diseases of the brain associated with aging. PMID: 16930777
    13. Important role of FLAP/leukotriene pathway in adaptive immunological circuits in vascular and adipose tissue inflammation. May be key regulator of T-cell-driven inflammatory and possible target in treatment of atherosclerosis and metabolic disease. PMID: 17379835
    14. identify multiprotein complexes for leukotriene synthesis on the outer and inner nuclear membranes of mast cells and neutrophils, centered on the 5-Lipoxygenase-Activating Protein and 5-Lipoxygenase PMID: 19075240
    15. FLAP mRNA is abundantly expressed in fetal mouse liver from e11.5 until delivery. PMID: 19358825

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  • 亚细胞定位：
    Nucleus membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.
  • 蛋白家族：
    MAPEG family
  • 数据库链接：

    KEGG: mmu:11690

    STRING: 10090.ENSMUSP00000071130

    UniGene: Mm.19844