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Recombinant Mouse Aquaporin-8 (Aqp8)

  • 中文名称：
    Recombinant Mouse Aquaporin-8(Aqp8)
  • 货号：
    CSB-CF001972MO
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
    Aqp8
  • Uniprot No.：
  • 别名：
    Aqp8; Aquaporin-8; AQP-8
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-261
  • 氨基酸序列
    MSGEQTPMCSMDLPEVKVKTSMAGRCRVFWYEQYVQPCIVELVGSALFIFIGCLSVIENSPNTGLLQPALAHGLALGLIIATLGNISGGHFNPAVSLAVTVIGGLKTMLLIPYWISQLFGGLIGAALAKVVSPEERFWNASGAAFAIVQEQEQVAEALGIEIILTMLLVLAVCMGAVNEKTMGPLAPFSIGFSVIVDILAGGSISGACMNPARAFGPAVMAGYWDFHWIYWLGPLLAGLFVGLLIRLLIGDEKTRLILKSR
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Forms a water-specific channel; mercury-sensitive. Also permeable to urea but not to glycerol.
  • 基因功能参考文献：
    1. AQP8 silencing impairs H2O2 entry into I.29micro+ B lymphoma cells. AQP8 can act as an efficient H2O2 channel also in cells of the B lineage. PMID: 27256569
    2. AQP8 has a role in the formation of follicles and provided new insight into the molecular mechanisms of folliculogenesis. PMID: 24020646
    3. Data indicate selective expression of aquaporins 3 and 8 in primitive erythroblasts and aquaporins 1 and 9 in adult definitive erythroblasts. PMID: 23243273
    4. we conclude that AQP8 deficiency increases the number of mature follicles by reducing the apoptosis of granulosa cells, thus increasing the fertility of female mice[aquaporin 8] PMID: 21117174
    5. Studies confirmed the involvement of AQP8 in alpha-amylase 2 regulation. PMID: 20939500
    6. Phenotype of AQP8-null mice is not dramatically different from wild type mice. PMID: 15647389
    7. analysis of AQP8 and AQP1 water channel expression in the mouse gall-bladder epithelium PMID: 15859952
    8. The results support the conclusion that AQP8 can facilitate NH(3) transport but provide evidence against physiologically significant AQP8-facilitated NH(3) transport in mice. PMID: 16624991
    9. The Hg(2+)-sensitive AQP8, which was localized in elongated spermatids and spermatozoa, is a likely candidate for a water channel responsible for physiological sperm volume regulation crucial to in vivo fertilization. PMID: 18829704

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  • 亚细胞定位：
    Membrane; Multi-pass membrane protein.
  • 蛋白家族：
    MIP/aquaporin (TC 1.A.8) family
  • 组织特异性：
    Colon, liver, heart and placenta.
  • 数据库链接：

    KEGG: mmu:11833

    STRING: 10090.ENSMUSP00000033023

    UniGene: Mm.273175