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Recombinant Mouse Aquaporin-1 (Aqp1)

  • 中文名称：
    Recombinant Mouse Aquaporin-1(Aqp1)
  • 货号：
    CSB-CF586908MO
  • 规格：
    ￥10508
  • 其他：

产品详情

  • 基因名：
    Aqp1
  • Uniprot No.：
  • 别名：
    Aqp1; Aquaporin-1; AQP-1; Aquaporin-CHIP; Delayed early response protein 2; DER2; Water channel protein for red blood cells and kidney proximal tubule
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length
  • 来源：
    in vitro E.coli expression system
  • 表达区域：
    1-269
  • 氨基酸序列
    MASEIKKKLFWRAVVAEFLAMTLFVFISIGSALGFNYPLERNQTLVQDNVKVSLAFGLSIATLAQSVGHISGAHLNPAVTLGLLLSCQISILRAVMYIIAQCVGAIVATAILSGITSSLVDNSLGRNDLAHGVNSGQGLGIEIIGTLQLVLCVLATTDRRRRDLGGSAPLAIGLSVALGHLLAIDYTGCGINPARSFGSAVLTRNFSNHWIFWVGPFIGGALAVLIYDFILAPRSSDFTDRMKVWTSGQVEEYDLDADDINSRVEMKPK
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Forms a water-specific channel that provides the plasma membranes of red cells and kidney proximal tubules with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient.
  • 基因功能参考文献：
    1. AQP1 may play an important role in the homeostasis of maternal-fetal fluid at late gestation days. PMID: 29626438
    2. AQP1 is expressed in atherosclerotic lesion neovasculature in human and mouse arteries and AQP1 deficiency augments lesion development in angiotensin II-promoted atherosclerosis in mice. PMID: 28129470
    3. AQP0 modulates GJs in the presence of BF proteins to maintain lens transparency and homeostasis. PMID: 29196765
    4. Our results demonstrate that Aqp1 is maternally expressed in the placenta, and that its deficiency resulted in placental abnormalities in the mouse. Aqp1 may have a specific inhibitory role in mouse placental development. PMID: 27307076
    5. Data show that overexpression of manganese superoxide dismutase (MnSOD) increased the expression of aquaporin-1 (AQP1) PMID: 27383386
    6. AQP1 deficiency delays long-term ischemia-reperfusion resolution, partly through repressing angiogenesis mediated by destabilizing HIF-2alpha. PMID: 26649797
    7. The results demonstrate that the descending thin limb (DTL) of the intermediate loop is composed of type I epithelium and expresses both AQP1. The functional role of the DTL of the intermediate loop may be distinct from the short or long loops. PMID: 27091563
    8. data suggest an important functional role of AQP1 in the pathobiology of hypoxia-induced pulmonary hypertension PMID: 28409279
    9. Angiotensinogen-mediated downregulation of aquaporin 1 and Nrf2 signalling may play an important role in intrarenal renin-angiotensin system-induced hypertension and kidney injury. PMID: 27638854
    10. The results suggest an important role of AQP1-mediated plasma membrane water permeability in maternal-fetal fluid balance PMID: 26014508
    11. AQP1 deficiency reduced microvascular permeability via the stabilization of HIF-1alpha levels in endothelial cells and decreased cellular apoptosis following MI. PMID: 26348407
    12. These data provide the first direct experimental evidence for the functional relevance of endothelial AQP1 to the fluid transport in peritoneal dialysis PMID: 26760974
    13. Reduction of cardiac aquaporin 1 and angiogenic factor expression level might be associated with high-salt-induced hypertension and cardiac injuries in mice, and could be ameliorated by angiotensin II receptor blocker treatment. PMID: 25659450
    14. the presence of AQP1 modifies the expression of key cell cycle proteins apparently related to increases in cell proliferation PMID: 26081645
    15. AQP1 oppositely regulates macrophage migration, depending on stimulation or not by LPS. PMID: 25719758
    16. The pro-inflammatory cytokine, interferon-gamma may contribute to diarrhea associated with intestinal inflammation in part through regulation of the epithelial aquaporin-1 water channel via a non-classical JAK/STAT receptor signalling pathway. PMID: 25793528
    17. Aqp1 activation by tubular fluid shear stress, serving to maintain glomerulotubular balance. PMID: 25270072
    18. implicate AQP1 as a novel determinant in renal cyst development that may involve inhibition of Wnt signaling by an AQP1-macromolecular signaling complex PMID: 25573755
    19. This study demonstrated that there was a temporal relationship with an increased expression of AQP1 following injury sustained to the sciatic nerve that was significantly observed in dorsal root ganglia and spinal cord. PMID: 25119150
    20. Rotavirus diarrhea is associated with the downregulation of AQP1, -4, and -8 expression. PMID: 25160756
    21. Aquaporin-1 water permeability is a novel determinant of dorsal root ganglion axonal regeneration. PMID: 25585012
    22. Lung AQP1 and AQP5 expression were significantly decreased in mice with acute lung injury together with increased inflammatory reaction and apoptosis of alveolar epithelial and vascular endothelial cells PMID: 24879973
    23. We conclude that AQP1 is not necessary for acutely stimulated renin secretion in vivo and from isolated perfused kidneys PMID: 25339696
    24. a new function of AQP in the inflammatory process PMID: 24700466
    25. A critical role of AQP1 in placental and fetal growth and maternal-fetal fluid homeostasis. PMID: 23808411
    26. knockout mouse studies showed water influx into the CSF is regulated by AQP-4, and not by AQP-1 PMID: 24231830
    27. Inhibition of AQP1 dependent angiogenesis impairs tumor growth in a mouse model of melanoma. PMID: 23197380
    28. HIF-1alpha participates in the hypoxic induction of the AQP1 gene PMID: 23948641
    29. results implicate AQP1 as an important determinant of tumor angiogenesis and, hence, as a potential drug target for adjuvant therapy of solid tumors PMID: 24334548
    30. The capacity of non-AQP1-dependent transcellular proximal fluid reabsorption (PFR) is sufficient to be maintained in AQP1- and claudin-2-doubly deficient knockout mice. PMID: 24049145
    31. Silicic acid in drinking water prevents age-related alterations in the endothelium-dependent vascular relaxation modulating eNOS and AQP1 expression in experimental mice. PMID: 23177919
    32. Cardioplegia, ischemia and hypoxia decrease AQP1 mRNA as well as total protein expression and glycosylation, possibly regulated by miR-214. PMID: 23238222
    33. Data indicate selective expression of aquaporins 3 and 8 in primitive erythroblasts and aquaporins 1 and 9 in adult definitive erythroblasts. PMID: 23243273
    34. As in the brain, expression of AQP1 and -4 in the heart is influenced by changes in plasma osmolality. PMID: 22820194
    35. Selective expression of AQP1 in the trigeminal neurons innervating the oral mucosa indicates an involvement of AQP1 in oral sensory transduction. PMID: 23029502
    36. Relaxin regulates hyaluronan synthesis and aquaporins in the cervix of late pregnant mice PMID: 23087172
    37. Elevated expressions of AQP1 mRNA were associated with increased volume of malignant pleural effusion. PMID: 21519870
    38. results indicate that AQP1 and AQP5 are closely related to pulmonary edema but not to eosinophil infiltration or mucus secretion during asthma. PMID: 22226856
    39. AQP1 abundance is 42.7% lower in the choroid plexus epithelium of solute carrier family 4 sodium bicarbonate cotransporter-like (Slc4a10)-deficient mice. PMID: 22357733
    40. The activation of Aqp1 promoter by hypoxia is complex and multifactorial and suggest that besides HIF-1alpha other transcription factors might contribute to this regulatory process. PMID: 22174795
    41. The persistent high urine volume after arginine vasopressin administration was traced to a reduction in aquaporin-1 expression in the kidney of LXRbeta(-/-) mice. PMID: 22323586
    42. A pretranslational regulation occurs in iodoacetamide-induced AQP1 expression in mouse fibroblasts, and the up-regulated AQP1 accumulation is characterized by mitochondria-related energy dependence. PMID: 21269951
    43. AQP1 promotes angiogenesis, fibrosis, and portal hypertension after bile duct ligation and is regulated by osmotically sensitive miRNAs. PMID: 21854740
    44. The AQP1 and AQP3 genes were expressed in the secretary epithelia of the mouse prostate tissue, which suggests that AQP1 and AQP3 may play an important role in the secretion of prostatic fluid. PMID: 21735643
    45. AQP-1 may reflect the status of aged IVDs and have a potential role in reflecting the adaptability of NP cells under different adverse ECM environments in aging degenerated IVDs. PMID: 21451971
    46. increased water permeability through AQP1 does not compensate for loss of AQP0 expression in TgAQP1(+/+)/AQP0(-/-) mice. Fiber cell AQP0 expression is required to maintain their organization, which is a requisite for lens transparency PMID: 21511033
    47. An increased level of Aqp4 protein, but not Aqp1, protein is demonstrated in a membrane-enriched fraction of cortical brain tissue, obtained from mice induced with acute liver injury, hyperammonemia and brain edema. PMID: 20938728
    48. The reduced ventricular size in AQP1-deficient mice following kaolin-induced hydrocephalus suggests AQP1 inhibition or down-regulation as a potential adjunctive treatment for hydrocephalus. PMID: 21040788
    49. AQP1 was localized on the cell processes of the fibrocytes in the endolymphatic sac. PMID: 17633275
    50. Data suggest that aquaporin 1 expression represents an important distinguishing characteristic of olfactory ensheathing glia, which may impart unique function to these glia. PMID: 20853510

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    MIP/aquaporin (TC 1.A.8) family
  • 组织特异性：
    Detected in erythrocytes (at protein level). In the kidney, expressed on luminal and basal borders of proximal tubules and in the thin limb of Henle's loop (at protein level).
  • 数据库链接：

    KEGG: mmu:11826

    STRING: 10090.ENSMUSP00000004774

    UniGene: Mm.18625