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  4. Recombinant Human UDP-glucuronosyltransferase 1-6 (UGT1A6)

Recombinant Human UDP-glucuronosyltransferase 1-6 (UGT1A6)

  • 货号：
    CSB-CF025579HU
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
    UGT1A6
  • Uniprot No.：
  • 别名：
    UGT1A6; GNT1; UGT1; UDP-glucuronosyltransferase 1-6; UDPGT 1-6; UGT1*6; UGT1-06; UGT1.6; Phenol-metabolizing UDP-glucuronosyltransferase; UDP-glucuronosyltransferase 1-F; UGT-1F; UGT1F; UDP-glucuronosyltransferase 1A6
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    27-532
  • 氨基酸序列
    DKLLVVPQDGSHWLSMKDIVEVLSDRGHEIVVVVPEVNLLLKESKYYTRKIYPVPYDQEELKNRYQSFGNNHFAERSFLTAPQTEYRNNMIVIGLYFINCQSLLQDRDTLNFFKESKFDALFTDPALPCGVILAEYLGLPSVYLFRGFPCSLEHTFSRSPDPVSYIPRCYTKFSDHMTFSQRVANFLVNLLEPYLFYCLFSKYEELASAVLKRDVDIITLYQKVSVWLLRYDFVLEYPRPVMPNMVFIGGINCKKRKDLSQEFEAYINASGEHGIVVFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform has specificity for phenols. Isoform 3 lacks transferase activity but acts as a negative regulator of isoform 1.
  • 基因功能参考文献：
    1. high activityUGT1A6 genotype is associated with an increased risk for Warthin's tumor PMID: 25899702
    2. Rs28898617 (UGT1A6, A > G) variation was associated with an increase in NCVPA. PMID: 27855134
    3. Oxidative stress and histone modifications may promote transcriptional activation of Ugt1a6 and Ugt1a7 genes. PMID: 26684499
    4. Identified coding variants on UGT1A1 and UGT1A6 genes in association with serum bilirubin level and hyperbilirubinemia risk in elderly subjects. PMID: 26039129
    5. Evaluating the association of UGT1A6 2 Ser7Ala polymorphism with drug response, there was no significant difference in the genotypic distribution between responders and non-responders. PMID: 24036429
    6. Validation of variants in SLC28A3 and UGT1A6 as genetic markers predictive of anthracycline-induced cardiotoxicity in children. PMID: 23441093
    7. Lower adjusted plasma VPA concentrations were also observed in patients with UGT1A6 double heterozygosities than those with single heterozygosity. PMID: 23099353
    8. UGT1A6 polymorphisms may be used to identify people with increased risk of developing lung cancer PMID: 22912755
    9. Polymorphism in UDP-glucuronosyltransferase 1A6 is associated with colorectal cancer. PMID: 22901212
    10. the protective T allele of rs17863783 was found to be associated with increased mRNA expression of UGT1A6.1; study suggests that rs17863783 may protect from bladder cancer by increasing the removal of carcinogens from bladder epithelium by the UGT1A6.1 protein PMID: 22228101
    11. Dual polymorphisms of UDP glucuronosyl-transferases 1A6 and 1A1 in a patient with Gilbert's syndrome who had persistent hyperserotoninemia that responded to octreotide are reported. PMID: 22450351
    12. analysis of UGT1A6 variants and aspirin use in a randomized trial of celecoxib for prevention of colorectal adenoma PMID: 22030088
    13. The percentage of APAP was higher among UGT1A6*1/*1 genotypes, relative to *1/*2 and *2/*2 genotypes (P = 0.045). PMID: 21666065
    14. development of UGT1A1 and 1A6 was studied in 50 pediatric liver samples; data imply independent regulation of UGT1A1 and 1A6 where activity has matured after 6 months to 1 year PMID: 21266593
    15. A positive association is found between UGT1A6 genotypes and the occurrence of anti-tuberculosis drug induced hepatic-injury. PMID: 21586239
    16. evaluated cross-sectionally whether urinary excretion of ASA and its metabolites differed by UGT1A6 genotype and dietary factors shown to induce UGT PMID: 21625173
    17. Letter: Results suggest that a small breast cancer risk conveyed by UGT1A1 and UGT1A6 variants may be further amplified by the experience of persisting stressful events. PMID: 20686835
    18. The induction of UGT1A6 by methotrexate alone or in combination with other antineoplastics is reported. PMID: 20854796
    19. Subjects carrying allele of MPO rs7208693 A and UGT1A6 rs6759892 G or rs1105879 C at the same time could be more susceptible to chronic benzene poisoning. PMID: 17424838
    20. In a study of Japanese renal transplant recipients, there are no significant differences in the area under the plasma concentration-time curve ratio of mycophenolic acid glucuronide/MPA between UGT1A6 I399C/T genotypes. PMID: 18695635
    21. The subjects carrying GSTP1rs947894 AG/GG genotypes and UGT1A6 rsl105879 AA genotypes could be more susceptible to vinyl chloride monomer-induced DNA damage. PMID: 19267064
    22. UGT1A6 A541G gene polymorphism does not influence serum concentrations of valproic acid in Han epileptic children. PMID: 20540849
    23. kinetic studies of UGT1A6 metabolizing psilocin (a hallucinogenic indole alkaloid) and 4-hydroxyindole PMID: 20007669
    24. Data identified five different genotypes in UGT1A6, demonstrating a high variability of alleles and haplotypes, which have important roles in modifying expression and activity of UGTs. PMID: 19712005
    25. relevance of cysteine 126 in the glucuronidation process PMID: 12009407
    26. Most patients with Gilbert's syndrome may have abnormalities in glucuronidation of aspirin or coumarin- and dopamine-derivatives, due to this combination of UGT1A1*28 and UGT1A6*2 genotypes. PMID: 12480553
    27. These results demonstrate for the first time glucuronidation of catechols by gastric and intestinal microsomal UGTs and three human recombinant UGT isoforms.Recombinant human UGT1A6, 1A9, and 2B7 effectively catalyzed catechol glucuronidation PMID: 12623074
    28. Human UGT1A6 plays a predominant role in the glucuronidation of 5-hydroxytryptophol and N-acetylserotonin, whereas 6-hydroxymelatonin is not a substrate for this enzyme. PMID: 15258112
    29. Genetic polymorphisms in UGT1A6 is associated with colorectal cancer PMID: 15319294
    30. Genotyping of UGT1A6 in the Japanese, and probably other Asian populations. PMID: 15770079
    31. Structure and function of UGT1A6 is reviewed. PMID: 16399343
    32. Role of the Ah receptor in induction of enzyme UGT1A1 is reviewed. PMID: 16399344
    33. Total or partial deletion of the stop transfer sequence of UGT1A6 severely impaired enzyme activity highlighting its importance in both membrane assembly and function. PMID: 16529747
    34. Coinfections with UGT1A4 increased the normalized scopoletin glucuronidation of 6YD (the Y485D mutant of UGT1A6) much more than it affected 1YD (the Y486D mutant of UGT1A1). PMID: 17301691
    35. Paracetamol disposition can be used as a probe to assess UGT1A6 ontogeny in the first months of life. PMID: 17609736
    36. UGT1A6 is a major contributor to glucuronidation of apigenin but not genistein in intact Caco-2 cells and in cell lysates PMID: 17927138
    37. HNF1alpha and HNF4alpha are the factors involved in the interindividual variability of liver UGT1A6 and UGT1A9 mRNA expression. PMID: 17965524
    38. The studied single nucleotide polymorphisms in UGT1A6 do not appear to exert statistically significant effects on the single-dose pharmacokinetics of deferiprone. PMID: 18318774
    39. In females receiving ASA, the presence of the UGT1A6*2 compared to the UGT1A6*1 homozygote genotype is associated with lower plasma levels of SA, indicating faster pharmacokinetics. PMID: 19262071
    40. the N-terminal portion of UGT1A6 is an antigenic site; sera from autoimmune hepatitis type 1 patients reacted with amino acids in the sequence 33-37 (PQDGS) of the N-terminal of UGT1A6. PMID: 19356052
    41. Characterizing the effects of common UDP glucuronosyltransferase (UGT) 1A6 and UGT1A1 polymorphisms on cis- and trans-resveratrol glucuronidation. PMID: 19406951
    42. study does not support a role of COX2 and UGT1A6 genetic variations in the development of colon cancer PMID: 19437564
    43. Oolymorphisms in UGT1A6 may contribute to interindividual and intra-ethnic differences, which may be helpful in the development of pharmacogenomics in China. PMID: 19450126
    44. Single-nucleotide polymorphisms, T181A of the UGT1A6 gene is found to be significantly associated with the risk of asthma. PMID: 19575027
    45. Genetic polymorphisms in UDP-glucuronosyltransferase 1A6 are not associated with NSAIDs-related peptic ulcer haemorrhage. PMID: 19799547
    46. Observational study of gene-environment interaction and healthcare-related. (HuGE Navigator) PMID: 16305586

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  • 亚细胞定位：
    Microsome. Endoplasmic reticulum membrane; Single-pass membrane protein.
  • 蛋白家族：
    UDP-glycosyltransferase family
  • 组织特异性：
    Expressed in skin. Isoforms 1 and 3 are expressed in kidney and liver. Isoform 1 but not isoform 2 is expressed in colon, esophagus and small intestine.
  • 数据库链接：

    HGNC: 12538

    OMIM: 191740

    KEGG: hsa:54578

    STRING: 9606.ENSP00000303174

    UniGene: Hs.554822