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  4. Recombinant Human Thromboxane-A synthase (TBXAS1)

Recombinant Human Thromboxane-A synthase (TBXAS1)

  • 货号：
    CSB-CF023261HU
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
    TBXAS1
  • Uniprot No.：
  • 别名：
    TBXAS1; CYP5; CYP5A1; TXAS; Thromboxane-A synthase; TXA synthase; TXS; Cytochrome P450 5A1; Hydroperoxy icosatetraenoate dehydratase
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-533
  • 氨基酸序列
    MEALGFLKLEVNGPMVTVALSVALLALLKWYSTSAFSRLEKLGLRHPKPSPFIGNLTFFR QGFWESQMELRKLYGPLCGYYLGRRMFIVISEPDMIKQVLVENFSNFTNRMASGLEFKSV ADSVLFLRDKRWEEVRGALMSAFSPEKLNEMVPLISQACDLLLAHLKRYAESGDAFDIQR CYCNYTTDVVASVAFGTPVDSWQAPEDPFVKHCKRFFEFCIPRPILVLLLSFPSIMVPLA RILPNKNRDELNGFFNKLIRNVIALRDQQAAEERRRDFLQMVLDARHSASPMGVQDFDIV RDVFSSTGCKPNPSRQHQPSPMARPLTVDEIVGQAFIFLIAGYEIITNTLSFATYLLATN PDCQEKLLREVDVFKEKHMAPEFCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEV LGQRIPAGAVLEMAVGALHHDPEHWPSPETFNPERFTAEARQQHRPFTYLPFGAGPRSCL GVRLGLLEVKLTLLHVLHKFRFQACPETQVPLQLESKSALGPKNGVYIKIVSR
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Catalyzes the conversion of prostaglandin H2 (PGH2) to thromboxane A2 (TXA2), a potent inducer of blood vessel constriction and platelet aggregation. Cleaves also PGH2 to 12-hydroxy-heptadecatrienoicacid (12-HHT) and malondialdehyde, which is known to act as a mediator of DNA damage. 12-HHT and malondialdehyde are formed stoichiometrically in the same amounts as TXA2. Additionally, displays dehydratase activity, toward (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate (15(S)-HPETE) producing 15-KETE and 15-HETE.
  • 基因功能参考文献：
    1. RS41708TT is not only independent risk factor for symptomatic carotid artery or intracranial arterial stenosis, but is also independent risk predictor for neurologic deterioration in ischemic stroke patients. PMID: 28108096
    2. Sequencing revealed two novel biallelic variants of unknown significance within the thromboxane A synthase gene, TBXAS1 (c.266T > C; c.989T > C), bioinformatically predicted to disrupt the protein. TBXAS1 mutations result in Ghosal hematodiaphyseal dysplasia (OMIM 231095), the autosomal recessive syndrome associated with abnormal bone structure and BMF. PMID: 28868793
    3. TXAS1 rs2267679TT and rs41708TT genotypes are associated with carotid plaque vulnerability, platelet activation and TXA2 levels in ischemic stroke patients. PMID: 28704403
    4. the administration of salted drinking water (2.7% NaCl) to wild-type mice resulted in elevated placental TXA2 synthase (TXAS) and plasma thromboxane A2, but not prostacyclin, levels, which was also found in clinical preeclampsia placenta samples. PMID: 26974824
    5. Single nucleotide polymorphisms of TBXAS1 are associated with susceptibility to gout in ethnic Han males population. PMID: 26252103
    6. The cardiovascular events significantly morefrequently occurred during 12 and 18 months in resistant diabetics and in the patients with an allele lacking the *2/*3 CYP2C9 gene function and AT/TT polymorphism of the thromboxane synthase gene TBS1. PMID: 26117917
    7. The carriage of Thromboxane A synthase 1 gene polymorphism AA was shown to affect the risk of clopidogrel resistance. PMID: 26027242
    8. study suggests that the anti-tumor effect of glycyrrhizin in lung adenocarcinoma is, at least in part, TxAS-dependent. PMID: 24556579
    9. 12-HHT is produced by both TxAS-dependent and TxAS-independent pathways in vitro and in vi PMID: 24009185
    10. In this study we have showed, for the first time, a significant role of the minor allele rs6962291 of TBXAS1 in patients with NSAID acute cutaneous hypersensitivity. PMID: 23763970
    11. The increased Km and decreased Vmax values observed with L357V suggest that this variant may generate less TXA2 at the low levels of PGH2 expected in vivo, raising the possibility of attenuated signaling through the thromboxane pathway. PMID: 22735388
    12. Data show that that DNA methylation of the TBXAS1 promoter was decreased and thromboxane synthase expression was increased in omental arteries of preeclamptic women as compared with normal pregnant women. PMID: 22493072
    13. these results showed that visfatin promoted IL-8 production by upregulation of TXAS, leading to angiogenic activation in endothelial cells. PMID: 22293189
    14. Rs10487667 polymorphism in the CYP5A1 gene might be a risk factor of myocardial infarction in the Uigur population in Xinjiang. PMID: 21215134
    15. Data suggest that targeting thromboxane synthase alone, or in combination with conventional chemotherapy is a potential therapeutic strategy for NSCLC. PMID: 21388528
    16. The rare allele of rs6962291 may play a protective role against aspirin hypersensitivity via a lower catalytic activity of the TBXAS1 gene, attributed to the increase of a nonfunctioning isoform of TBXAS1. PMID: 21449675
    17. The TC genotype and T allele of thromboxane synthase are risk factors of myocardial infarction. PMID: 20931532
    18. Apoptosis induced in lung cancer cells by the thromboxane synthase inhibitor 1-benzylimidazole is associated with the over-production of ROS and the reduction of NF-kappaB. PMID: 20647010
    19. In humans, TXAS was expressed in the atherosclerotic lesion, associated with increased inflammatory cells, in particular M2 polarized macrophages, and increased in atherosclerotic lesions of patients with recent symptoms of thrombotic events. PMID: 20383787
    20. Gene transfer of thromboxane A(2) synthase and prostaglandin I(2) synthase antithetically altered tumor angiogenesis and tumor growth. PMID: 11782360
    21. Transcriptional control of the human thromboxane synthase gene in vivo and in vitro. PMID: 11956185
    22. structure and function of the gene and protein - review PMID: 12432933
    23. Cox-2 and TBXAS may play an important role in pituitary tumor development and progression PMID: 15067173
    24. Significantly higher expression of thromboxane synthase is associated with metastasis in non-small cell lung cancer PMID: 15870920
    25. Overexpression of thromboxane synthase is associated with invasive bladder cancer PMID: 16357168
    26. Thromboxane synthase mutations in an increased bone density disorder (Ghosal syndrome). PMID: 18264100
    27. TBXAS1 genetic variation is associated with incident myocardial infarction. PMID: 19046748
    28. The results suggest specific TBXAS1 gene polymorphisms may be a useful marker for development of cerebral infarction, especially SAO type in Korean population. PMID: 19403042

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  • 相关疾病：
    Ghosal hematodiaphyseal dysplasia (GHDD)
  • 亚细胞定位：
    Endoplasmic reticulum membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Cytochrome P450 family
  • 组织特异性：
    Platelets, lung, kidney, spleen, macrophages and lung fibroblasts.
  • 数据库链接：

    HGNC: 11609

    OMIM: 231095

    KEGG: hsa:6916

    UniGene: Hs.520757