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  4. Recombinant Human Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 2 (NKAIN2)

Recombinant Human Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 2 (NKAIN2)

  • 货号：
    CSB-CF733165HU
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
    NKAIN2
  • Uniprot No.：
  • 别名：
    NKAIN2; FAM77B; TCBA1; Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 2; Na(+/K(+-transporting ATPase subunit beta-1-interacting protein 2; Protein FAM77B; T-cell lymphoma breakpoint-associated target protein 1
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-208
  • 氨基酸序列
    MGYCSGRCTLIFICGMQLVCVLERQIFDFLGYQWAPILANFVHIIIVILGLFGTIQYRPR YITGYAVWLVLWVTWNVFVICFYLEAGDLSKETDLILTFNISMHRSWWMENGPGCTVTSV TPAPDWAPEDHRYITVSGCLLEYQYIEVAHSSLQIVLALAGFIYACYVVKCITEEEDSFD FIGGFDSYGYQGPQKTSHLQLQPMYMSK
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 基因功能参考文献：
    1. NKAIN2 is a novel tumor suppressor gene whose activity is commonly reduced in prostate cancer PMID: 27588475
    2. Inhibiting miR-181d may suppress pancreatic cancer development, possibly through the inverse regulation on NKAIN2. PMID: 28381166
    3. High levels of NKAIN2 were detected in the MYCN-amplified NB cell lines. PMID: 24205241
    4. T-cell lymphoma breakpoint associated target 1 is a possible target gene for T-cell lineage-specific chromosome aberrations at 6q21. PMID: 11979551
    5. It is concluded that germline alterations of the TCBA1 gene are associated with developmental delay and typical physical features. PMID: 15908570

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  • 相关疾病：
    A chromosomal aberration involving NKAIN2 is a cause of lymphoma. Deletion del(6)(q13q21) within NKAIN2 and involving SUSP1 generates the SUSP1-NKAIN2 product (PubMed:11979551).
  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    NKAIN family
  • 组织特异性：
    Expressed in fetal brain. Weakly expressed in adult brain and thymus. Not expressed in any other normal tissue examined.
  • 数据库链接：

    HGNC: 16443

    OMIM: 609758

    KEGG: hsa:154215

    STRING: 9606.ENSP00000357402

    UniGene: Hs.656604