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  4. Recombinant Human Ribonuclease kappa (RNASEK)

Recombinant Human Ribonuclease kappa (RNASEK)

  • 货号：
    CSB-CF761293HU
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
    RNASEK
  • Uniprot No.：
  • 别名：
    RNASEK; Ribonuclease kappa; RNase K; RNase kappa
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-98
  • 氨基酸序列
    MASLLCCGPKLAACGIVLSAWGVIMLIMLGIFFNVHSAVLIEDVPFTEKDFENGPQNIYN LYEQVSYNCFIAAGLYLLLGGFSFCQVRLNKRKEYMVR
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Endoribonuclease which preferentially cleaves ApU and ApG phosphodiester bonds. Hydrolyzes UpU bonds at a lower rate.; (Microbial infection) Required for the initial stages of clathrin-mediated endocytic uptake of a diverse set of viruses, including dengue, West Nile, Sindbis, Rift Valley Fever, and influenza viruses. Not required for clathrin-mediated endocytosis and macropinocytosis.
  • 基因功能参考文献：
    1. Low Rnase K expression is associated with prostate cancer. PMID: 30054827
    2. Analyses of global gene expression data from adipose tissue, skeletal muscle, and whole blood provide evidence that rs75493593 is associated with RNASEK gene expression, suggesting that RNASEK expression may mediate the effect of genotype on diabetes. PMID: 26487785
    3. RNASEK closely associates with the V-ATPase and is required for its function; its loss prevents the early events of endocytosis and the replication of multiple pathogenic viruses. PMID: 26212330
    4. Data suggest that the Cys6-Cys69 disulfide bond is likely to exist in all RNase kappa family members, including human. PMID: 22324914
    5. Observational study of gene-disease association. (HuGE Navigator) PMID: 19913121
    6. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) PMID: 20628086
    7. Based on sequence alignment and substrate specificity data, as well as the resistance of the protein to the placental ribonuclease inhibitor, the human RNase kappa may be a novel endoribonuclease distinct from other known ribonucleases. PMID: 17881363

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  • 亚细胞定位：
    Membrane; Multi-pass membrane protein.
  • 蛋白家族：
    RNase K family
  • 组织特异性：
    Widely expressed.
  • 数据库链接：

    HGNC: 33911

    KEGG: hsa:440400

    STRING: 9606.ENSP00000449500

    UniGene: Hs.632232