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  4. Recombinant Human Protein lifeguard 2 (FAIM2)

Recombinant Human Protein lifeguard 2 (FAIM2)

  • 货号：
    CSB-CF866298HU
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
    FAIM2
  • Uniprot No.：
  • 别名：
    FAIM2; KIAA0950; LFG; LFG2; NMP35; TMBIM2; Protein lifeguard 2; Fas apoptotic inhibitory molecule 2; Neural membrane protein 35; Transmembrane BAX inhibitor motif-containing protein 2
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-316
  • 氨基酸序列
    MTQGKLSVANKAPGTEGQQQVHGEKKEAPAVPSAPPSYEEATSGEGMKAGAFPPAPTAVP LHPSWAYVDPSSSSSYDNGFPTGDHELFTTFSWDDQKVRRVFVRKVYTILLIQLLVTLAV VALFTFCDPVKDYVQANPGWYWASYAVFFATYLTLACCSGPRRHFPWNLILLTVFTLSMA YLTGMLSSYYNTTSVLLCLGITALVCLSVTVFSFQTKFDFTSCQGVLFVLLMTLFFSGLI LAILLPFQYVPWLHAVYAALGAGVFTLFLALDTQLLMGNRRHSLSPEEYIFGALNIYLDI IYIFTFFLQLFGTNRE
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Antiapoptotic protein which protects cells uniquely from Fas-induced apoptosis. Regulates Fas-mediated apoptosis in neurons by interfering with caspase-8 activation. May play a role in cerebellar development by affecting cerebellar size, internal granular layer (IGL) thickness, and Purkinje cell (PC) development.
  • 基因功能参考文献：
    1. results suggest that high level miR-3202 in T lymphocytes may protect epithelial cells through targeting FAIM2. MiR-3202 might be used as a notable biomarker of chronic obstructive pulmonary disease . PMID: 29208459
    2. that miR-193b is indispensible for the competitive endogenous RNA role of SNHG7 in FAIM2-supported tumourigenesis of lung cancer PMID: 29131440
    3. FAIM2 expression is significantly downregulated in human masticatory mucosa during wound healing PMID: 28005267
    4. our research showed that lncRNA-SNHG7 promotes the proliferation, migration and invasion, and inhibits apoptosis of lung cancer cells by enhancing the FAIM2 expression, suggesting that lncRNA-SNHG7 as a key regulator of gene expression, may be a promising therapeutic strategy for the treatment of lung cancer PMID: 27666964
    5. The interaction of TRIM21 and LFG was analyzed by co-immunoprecipitation. To examine changes in regulatory processes, western blot analyses, real-time PCR, activity of apoptotic process and flow cytometric analyses were carried out. PMID: 26398169
    6. There are significant differences in the associations of the FAIM2 promoter methylation with sedentary behaviour and physical activity between obese and lean children. PMID: 25922107
    7. Methylation levels of the FAIM2 promoter are significantly associated with obesity and are independently associated with dyslipidaemia and its components in Chinese children. PMID: 25696115
    8. Low KRT13 mRNA expression is associated with oral squamous cell carcinoma. PMID: 25735388
    9. These results suggest that the TMBIM family has comparable functions in the maintenance of intracellular Ca(2) homeostasis in a wide variety of tissues PMID: 25764978
    10. Results indicated that FAIM2 beta-isoform is strongly expressed in breast tumour tissues. Fas sensitivity was reduced in the MCF10A breast cells expressing the FAIM2 beta-isoform. PMID: 25069766
    11. This study highlighted the importance of two candidate genes, SH2B1 and FAIM2, in the risk of overweight/obesity. PMID: 24621099
    12. A polymorphism in FAIM2 is associated with higher myocardial infarction risk in type-2 diabetes mellitus subjects. PMID: 24393375
    13. The rs7138803 variant of FAIM2 was found to exert no effect on obesity in a Chinese Han population. PMID: 23924573
    14. Faim2 is physiologically expressed in brain in bacterial meningitis. PMID: 24335530
    15. Analysis identified SNPs at three loci known to be associated with BMI with genome-wide confidence (P<5x10(-8); FTO, MC4R and FAIM2). PMID: 21935397
    16. LFG is required for proper development and survival of granular and Purkinje cells and LFG may play a role in cerebellar disorders PMID: 21957071
    17. LFG is strongly expressed in breast cancer epithelial cells. Moreover, the overexpression of LFG correlated with tumour grade and reduced Fas sensitivity. PMID: 20336406
    18. Data show that SNPs in SEC16B and TMEM18 were significantly associated with obesity, and the SNPs in GNPDA2, BDNF, FAIM2 and MC4R were marginally associated with obesity in Japanese. PMID: 19851340
    19. Human keratinocytes were transfected with either Flip, Faim, or Lifeguard (LFG). Our results suggest that heterotopic expression of antiapoptotic proteins can induce the resistance of keratinocytes to a major mechanism of rejection. PMID: 17912957
    20. The tmbim2 may participate in cell death regulation by interacting with proteins of Bcl-2 family, promoting tumor metastasis, which is deduced from the evolutionary conservation of the membrane protein family containing multiple membrane spanning segments PMID: 18440869

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein. Membrane raft. Cell junction, synapse, postsynaptic cell membrane.
  • 蛋白家族：
    BI1 family, LFG subfamily
  • 组织特异性：
    Highly expressed in breast carcinoma tissues. Enhanced expression correlates with the grade of the tumor (grade II/grade III) in primary breast tumors (at protein level). Widely expressed. Expressed at high levels in the brain especially in the hippocampu
  • 数据库链接：

    HGNC: 17067

    OMIM: 604306

    KEGG: hsa:23017

    STRING: 9606.ENSP00000321951

    UniGene: Hs.567424