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  4. Recombinant Human Prostaglandin D2 receptor 2 (PTGDR2)

Recombinant Human Prostaglandin D2 receptor 2 (PTGDR2)

  • 货号：
    CSB-CF896745HU
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
  • Uniprot No.：
  • 别名：
    PTGDR2; CRTH2; DL1R; GPR44; Prostaglandin D2 receptor 2; Chemoattractant receptor-homologous molecule expressed on Th2 cells; G-protein coupled receptor 44; CD antigen CD294
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-395
  • 氨基酸序列
    MSANATLKPLCPILEQMSRLQSHSNTSIRYIDHAAVLLHGLASLLGLVENGVILFVVGCR MRQTVVTTWVLHLALSDLLASASLPFFTYFLAVGHSWELGTTFCKLHSSIFFLNMFASGF LLSAISLDRCLQVVRPVWAQNHRTVAAAHKVCLVLWALAVLNTVPYFVFRDTISRLDGRI MCYYNVLLLNPGPDRDATCNSRQVALAVSKFLLAFLVPLAIIASSHAAVSLRLQHRGRRR PGRFVRLVAAVVAAFALCWGPYHVFSLLEARAHANPGLRPLVWRGLPFVTSLAFFNSVAN PVLYVLTCPDMLRKLRRSLRTVLESVLVDDSELGGAGSSRRRRTSSTARSASPLALCSRP EEPRGPARLLGWLLGSCAASPQTGPLNRALSSTSS
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Receptor for prostaglandin D2 (PGD2). Coupled to the G(i)-protein. Receptor activation may result in pertussis toxin-sensitive decreases in cAMP levels and Ca(2+) mobilization. PI3K signaling is also implicated in mediating PTGDR2 effects. PGD2 induced receptor internalization. CRTH2 internalization can be regulated by diverse kinases such as, PKC, PKA, GRK2, GPRK5/GRK5 and GRK6. Receptor activation is responsible, at least in part, in immune regulation and allergic/inflammation responses.
  • 基因功能参考文献：
    1. The data indicate that expression of CRTh2 is regulated through the competitive action of GATA3 and NFAT1. PMID: 29969451
    2. The frequencies of the AA genotype of the CRTH2 rs545659 SNP and the CC genotype and the C allele of the CRTH2 rs634681 SNP were higher in patients with severe Hashimoto disease than in patients with mild Hashimoto disease. PMID: 29848886
    3. prediction of 3D structures for the DP prostaglandin GPCR, based on the GEnSeMBLE complete sampling with hierarchical scoring (CS-HS) methodology PMID: 29268008
    4. Report CRTh2 expression on vascular pericytes in the central nervous system and gastric mucosa. PMID: 27103662
    5. CRTh2 mediates most prostaglandin D2 pro-inflammatory effects and long receptor residence time of antagonist LAS191859 translates into long-lasting in vivo efficacy. PMID: 27317944
    6. CRTH2 plays a pro-inflammatory role in TNBS-induced colitis and Crohn's disease. Eosinophils contribute to the severity of the inflammation, which is improved by a selective CRTH2 antagonist. Serum levels of PGD2 and Delta(12)-PGJ2 were increased in Crohn's disease patients as compared with control individuals. PMID: 26928963
    7. this study shows that allergic rhinitis patients increased the amounts of VIP and PGD2 in their nasal secretions in the early phase reaction, however CRTH2 gene expression from leukocytes recovered in their nasal secretions was upregulated only during the late phase reaction PMID: 28222358
    8. the CRTH2 expression on thyroid-infiltrating lymphocytes as well as on lymphocytes from peripheral blood was increased in Hashimoto's thyroiditis as compared to controls. PMID: 27872865
    9. smaller proportion of group 2 innate lymphoid cells isolated from nondiseased human lung expressed CRTH2 PMID: 25850654
    10. Altered expression of chemoattractant CRTH2 on blood basophils and eosinophils in patients with chronic spontaneous urticaria PMID: 26194547
    11. Hypermethylation of the selected markers (MAL, PRIMA1, PTGDR and SFRP1) can result in reduced gene expression and may contribute to the formation of colorectal cancer. PMID: 26482433
    12. Data indicate that in ulcerative colitis, DP2 receptor showed higher expression in neutrophils but lower in monocytes, and CRTH2 receptor was decreased in eosinophils, NK, and CD3(+) T cells but not in monocytes and CD3(+)/CD4(+) T cells. PMID: 24929001
    13. Low DP2 prostanoid receptor is associated with gastric cancer progression. PMID: 24922638
    14. CRTh2 rs533116 was associated with allergic asthma in White people PMID: 22947041
    15. CRTH2 is not expressed on human amniocytes or myocytes and plays no role in the mechanism of 15dPGJ2-mediated inhibition of NF-kappaB PMID: 23226366
    16. Confocal images and FACS demonstrated a strong association and co-localization between VIP peptide and CRTH2 molecules PMID: 23168411
    17. These data show that prostaglandin D(2) induces human osteoclast apoptosis through activation of CRTH2 and the apoptosis intrinsic pathway. PMID: 22705147
    18. we show that CRTH2+ CD4+ T cells may be involved in the enhanced Th2 cell-mediated immunity in IgG4-related lacrimal gland enlargement. PMID: 22627365
    19. identify PGH(1) as an important lipid intermediate and novel CRTH2 agonist which may trigger CRTH2 activation in vivo in the absence of functional prostaglandin D synthase. PMID: 22442685
    20. This study provides the first clinical evidence that CRTH2 receptors contribute to airflow limitation, symptoms and eosinophilic airway inflammation in asthma. PMID: 21762224
    21. DP receptors amplify the biological response to CRTH2 activation and the CRTH2/DP heteromer might represent both a functional signaling unit for PGD(2) and a potential target for development of heteromer-directed therapy for allergic diseases PMID: 21930295
    22. The frequencies of the TT genotype of CRTH2 -466T>C were higher than those of the CC/CT genotype in aspirin-exacerbated respiratory disease patients compared to aspirin-tolerant asthma patients PMID: 22101342
    23. expression defines IL-25- and IL-33-responsive type 2 innate lymphoid cells PMID: 21909091
    24. DP mediates eosinophils through the elevation of intracellular cAMP production but does not change CRTH2 expression; balance between DP and CRTH2 could influence the degree of PGD2-induced eosinophil migration PMID: 21624751
    25. DK-PGD-induced CLC/Gal-10 mRNA level can serve as a potential marker for monitoring pharmacodynamic effects of blood exposure to CRTH2 modulating agents PMID: 20858065
    26. in immunologically activated nasal polyp tissue, PGD(2) produced by mast cells promotes the migration of Th2 cells through a CRTH2 dependent mechanism. PMID: 19839971
    27. The CRTH2 -466T>C polymorphism increases serum and cellular eotaxin-2 production through lowered CRTH2 expression PMID: 19796209
    28. CRTH2 was enriched significantly on interleukin (IL)-4+/IL-13+ T cells compared to interferon (IFN)-gamma+ T cells. There were more CRTH2+ T cells in the bronchoalveolar lavage (BAL) of asthmatics vs. controls. PMID: 20491797
    29. CRTH2 is GPR44, a G protein-coupled receptor 44. Characterization of C-terminal tail determinants involved in CRTH2 receptor trafficking identified a recycling motif. PMID: 20035740
    30. Indomethacin may exert its therapeutic effect in eosinophilic pustular folliculitis (Ofuji's disease) by reducing CRTH2 expression, as well as by inhibiting PGD2 synthesis. PMID: 20107720
    31. CRTH2 is involved in mediating some of the therapeutic and/or unwanted side effects of indomethacin, independently of cyclooxygenases and peroxisome proliferator-activated receptors. PMID: 11801628
    32. Association of a new-type prostaglandin D2 receptor CRTH2 with circulating T helper 2 cells in patients with atopic dermatitis. PMID: 12230502
    33. data show that 11-dehydro-thromboxane B(2) is a full agonist of the chemoattractant receptor-homologous molecule expressed on TH2 cells(CRTH2) receptor and hence might cause CRTH2 activation in cellular contexts PMID: 14668348
    34. CRTH2 protein structure and expression (review) PMID: 15065763
    35. Sequence variants of CRTH2 are associated with asthma and differentially influence mRNA stability. PMID: 15345705
    36. restoration of CRTH2/CCR3 expression may be an indicator for optimal recovery after septic shock PMID: 15507393
    37. selective effect of other PGD2 metabolites on CRTH2 PMID: 15789622
    38. analysis of prostaglandin D2 receptor CRTH2 determinants of ligand binding affinity and selectivity PMID: 16030019
    39. Data show that the prostaglandin PGD(2) metabolite, 9alpha,11beta-PGF(2), and its stereoisomer, PGF(2alpha), are CRTH2 chemoattractant receptor agonists. PMID: 16378605
    40. PGD(2) exerts its effects partly through CRTH2. The PGD(2)/CRTH2 system mediates the chemotaxis of eosinophils, basophils, & Th2 cells involved in the induction of allergic inflammation. Human bronchial epithelial cells express CRTH2. PMID: 17541272
    41. These data further emphasize the importance of CRTH2 in eosinophil function (recruitment, respiratory burst, and granulation). PMID: 17714552
    42. D-type prostanoid (DP) receptors comediate with CRTH2 the mobilization of eosinophils from bone marrow and their chemotaxis, which might provide the rationale for DP antagonists in the treatment of allergic disease PMID: 17878378
    43. demonstrated GATA-3 binding to a probe from the CRTh2 promoter PMID: 17910949
    44. relationship between G1544C and A1651G SNPs and serum IL-13 levels in Chinese children patients with asthma PMID: 18777142
    45. These results suggest that expression of DP and CRTH2 is associated with the pathophysiology of chronic rhinosinusitis, and the expression of these receptors may be regulated by h-PGDS and PGD. PMID: 18802357
    46. PGH2 causes activation of the PGD2 receptors CRTH2 and DP via a dual mechanism: by interacting directly with the receptors and/or by giving rise to PGD2 after catalytic conversion by plasma proteins. PMID: 18835884
    47. CRTH2 inhibition by its C terminus may represent a rather unappreciated strategy employed by a GPCR to specify the extent of G protein activation PMID: 19010788
    48. CRTH2 expressions of leukocytes in allergic nasal mucosa are significantly up-regulated compared with those in nonallergic nasal mucosa suggesting that CRTH2 may play an important role in the recruitment of leukocytes into allergic nasal mucosa PMID: 19230460
    49. The CRTH2 -466T>C gene polymorphism may not affect on the phenotype of chronic urticaria, but controbutes to the required dose of antihistamines in patients. PMID: 19290788
    50. Genetic variation within CRTh2 modifies the development of allergic sensitization and asthma in a population of German children. PMID: 19392992

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 1 family
  • 组织特异性：
    Widespread expression. High expression in stomach, small intestine, heart and thymus. Intermediate expression in colon, spinal cord and peripheral blood and low expression in brain, skeletal muscle and spleen. Expressed also on Th2- and Tc2- type cells, e
  • 数据库链接：

    HGNC: 4502

    OMIM: 604837

    KEGG: hsa:11251

    STRING: 9606.ENSP00000332812

    UniGene: Hs.299567