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  4. Recombinant Human Platelet-activating factor receptor (PTAFR)

Recombinant Human Platelet-activating factor receptor (PTAFR)

  • 货号：
    CSB-CF018946HU
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
  • Uniprot No.：
  • 别名：
    PTAFR; PAFR; Platelet-activating factor receptor; PAF-R; PAFr
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-342
  • 氨基酸序列
    MEPHDSSHMDSEFRYTLFPIVYSIIFVLGVIANGYVLWVFARLYPCKKFNEIKIFMVNLT MADMLFLITLPLWIVYYQNQGNWILPKFLCNVAGCLFFINTYCSVAFLGVITYNRFQAVT RPIKTAQANTRKRGISLSLVIWVAIVGAASYFLILDSTNTVPDSAGSGNVTRCFEHYEKG SVPVLIIHIFIVFSFFLVFLIILFCNLVIIRTLLMQPVQQQRNAEVKRRALWMVCTVLAV FIICFVPHHVVQLPWTLAELGFQDSKFHQAINDAHQVTLCLLSTNCVLDPVIYCFLTKKF RKHLTEKFYSMRSSRKCSRATTDTVTEVVVPFNQIPGNSLKN
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Receptor for platelet activating factor, a chemotactic phospholipid mediator that possesses potent inflammatory, smooth-muscle contractile and hypotensive activity. Seems to mediate its action via a G protein that activates a phosphatidylinositol-calcium second messenger system.
  • 基因功能参考文献：
    1. he PAFR gene rs5938 or rs313152 polymorphisms might be a potential biomarker for susceptibility to coronary heart disease. PMID: 28197937
    2. Weighted gene co-expression network analysis of gene modules for the prognosis of esophageal cancer yielded PTAFR and FGR as the most important hub genes for predicting patient survival. PMID: 28585144
    3. we demonstrate that PAFR inhibition can selectively enhances the sensitivity of radiotherapy in prostate cancer cells with elevated PAFR expression after irradiation exposure PMID: 28099922
    4. PAFR overexpression is associated with pneumococcal infection. PMID: 28278175
    5. WEB-2086 represents an innovative class of candidate drugs for inhibiting PAFr-dependent lung infections caused by the main bacterial drivers of smoking-related COPD. PMID: 27524890
    6. PAF stimulation dose-dependently promoted the invasion, migration and growth of prostate cancer cells in vitro, while knockdow our findings demonstrate that PAFR can activate ERK1/2 pathway, and subsequently increase MMP-3 expression and decrease E-cadherin expression PMID: 27176648
    7. PAFR is overexpressed in NSCLC as well as in breast, colorectal, and gastric carcinomas. PAFR expression correlates with clinical stages, survival time, and distant metastasis. PAF/PAFR signaling also upregulated IL6 expression and STAT3 activation. PMID: 26359459
    8. we made the first demonstration that dysregulation of PAFR and the positive regulatory loop between PAFR and pAKT contribute to malignant progression of esophageal squamous cell carcinoma PMID: 25639872
    9. Data support an important role for PAFR in tumor growth and suggest that engagement of PAFR interferes with selected pathways in macrophages, changing their phenotype into that of a regulatory with suppressor activities. [review] PMID: 25182608
    10. Epithelial PAFr expression is upregulated in smokers, especially in those with COPD, and is not obviously affected by inhaled corticosteroid therapy. PMID: 25143722
    11. Results suggest that WEB2086 and AG1478 are synergistic in ovarian cancer cells with high expression of both platelet-activating factor receptor (PAFR) and epidermal growth factor receptor (EGFR). PMID: 24886678
    12. PAFR may have an important role in modulating the cisplatin sensitivity of ovarian cancer cells. PMID: 24921917
    13. patients presenting elevated PAFR expression had significantly longer survival times compared to those with low PAFR expression (log-rank test, p<0.001). PMID: 24824933
    14. oxLDL induces the recruitment of PAFR and CD36 into the same lipid rafts, which is important for oxLDL uptake and IL-10 production PMID: 24130805
    15. Data suggest PAF/PAF receptor signaling exerts proinflammatory effect on neutrophil via down-regulation of LXRa (liver X receptor alpha) and target genes (ATP-binding cassette transporter (ABC) A1, ABC G1, sterol response element binding protein 1c). PMID: 24289152
    16. Inhibition of platelet aggregation by lipoteichoic acid was blocked using a monoclonal anti-PafR antibody and Ginkgolide B,a well-defined PafR antagonist, demonstrating that the LTA inhibitory signal occurs via PafR. PMID: 23911710
    17. oxLDL induces alternative macrophage activation by mechanisms involving CD36 and PAFR PMID: 24062612
    18. Data suggest that expression of PAFR and SIRT1 (sirtuin 1) is down-regulated in endothelial progenitor cells of type 2 diabetic patients with poor glycaemic control compared to those with good glycaemic control. PMID: 23070058
    19. An implication of platelet-activating factor receptor A224D mutation in the susceptibility to relapsing-remitting multiple sclerosis in Tunisian population. PMID: 21658861
    20. recognition of apoptotic cells by phagocytes leads to activation of PAFR pathways, resulting in a microenvironment response favorable to melanoma growth PMID: 22577252
    21. PAFR may have a role in tumor response mechanisms, such as stress responses caused by chemotherapeutic agents PMID: 22570511
    22. Eosinophils use their platelet-activating factor receptors (PAFRs) to interact directly with Staphylococcus aureus. PMID: 22595142
    23. Pneumococcal ligands keratin 10, laminin receptor and platelet-activating factor receptor are elevated in aged lungs and contribute to the enhanced susceptibility to pneumonia. PMID: 21615674
    24. Urban particulate matter (PM) increases adhesion of S. pneumoniae to human airway epithelial cells. PM-stimulated adhesion is mediated by oxidative stress and PAFR. PMID: 21247619
    25. Platelet-activating factor plays a pivotal role in the oxLDL-induced recruitment of hBMSCs through mechanisms involving platelet-activating factor receptor dependent activation of Mitogen-Activated Protein Kinases. PMID: 21063106
    26. The expression of PAF receptor (PAF-R) in early endothelial progenitor cell and the release of PAF under stimulation with factors involved in endothelial dysfunction, were investigated. PMID: 20637897
    27. Results reveal that some strains of Gram-positive bacteria exploit hypoxia-inducible factor 1 alpha-regulated platelet-activating factor receptor as a means for translocation through intestinal epithelial cells. PMID: 20032301
    28. role in activation of mast cells by PAF. PMID: 20392487
    29. conserved proline in TM6 is crucial for intracellular trafficking of PAFR. PMID: 20007715
    30. activates the extracellular signal-regulated kinase mitogen-activated protein kinase and induces proliferation of epidermal cells PMID: 11861812
    31. Neuroblastoma clone cells show an inverse relationship between invasiveness and differentiative capacity and by the expression of specific cell surface PAF receptors. PMID: 11928813
    32. PAF receptor transcripts in five human cancer cell lines derived from the breast (BT20, SKBR3 and T47D cells), the pancreas (Miapaca cells) and the bladder (5,637 cells) confirm the existence of a splice variant of the PAF-R transcript 2. PMID: 12467527
    33. a novel pathway whereby the epidermal PAF-R can augment chemotherapy-induced apoptotic effects through an NF-kappaB-dependent process PMID: 12601006
    34. the epidermal platelet-activating factor receptor augments staphylococcal alpha-toxin signaling PMID: 12713583
    35. platelet-activating factor receptor is desensitized and internalized by coumermycin-gyrase B-induced dimerization PMID: 12756251
    36. PAFR degradation can occur via both the proteasome and lysosomal pathways and ligand-stimulated degradation is ubiquitin-dependent PMID: 14500726
    37. platelet-activating factor receptor-mediated signaling has a critical role in differentiated endothelial cell functions, including cell migration and proteolytic activation of MMP2 PMID: 14617636
    38. investigated whether the increase of uPA monocyte expression and chemokine releases induced by oxidised low density lipoproteins involved proinflammatory phospholipid products having platelet-activating factor-like activity via the PAFR pathway PMID: 15149885
    39. Analysis of 102 B-CLL patients revealed dramatic differences for their membrane PAF-R expression, a result that might be related to their plasma IL-4 levels. PMID: 15160913
    40. the PAFR gene missense mutation has a relation to the susceptibility for multiple sclerosis . PMID: 15748960
    41. UVB photo-oxidizes cellular phospholipids, creating PAF analogs that stimulate the PAF receptor to induce further PAF synthesis and apoptosis PMID: 16115894
    42. PAF induced CREB and ATF-1 phosphorylation via a PAFR-mediated signal transduction mechanism that required pertussis toxin-insensitive Galphaq protein and adenylate cyclase activity and was antagonized by a cAMP-dependent PKA and p38 MAPK inhibitors. PMID: 16306050
    43. presence of functional PAF-R in arterial spindle-shaped smooth muscle cells of synthetic phenotype may be important for their migration from the media into the intima and atherosclerotic plaques formation PMID: 16793019
    44. The functional PAF-R are present in blast cells of patients with acute leukemia; a result that could be of physiologic importance regarding the important effect of PAF on leukocytes maturation and functions. PMID: 16837045
    45. These studies suggest that SZ95 sebocytes express functional PAF-Rs and PAF-Rs are involved in regulating the expression of inflammatory mediators, including COX-2, PGE(2) and IL-8. PMID: 16984258
    46. epidermal PAF-R can modulate UVB-mediated early gene expression PMID: 17928889
    47. a lower expression of PAFR in HCC correlated with both poor differentiation and portal venous invasion. PMID: 18187960
    48. analysis of PAFR activation and pleiotropic effects on tyrosine phospho-EGFR/Src/FAK/paxillin in ovarian cancer PMID: 18632638
    49. cis-urocanic acid stimulates mediator production by a pathway that is independent of these serotonin 2A and PAF receptors in human keratinocytes PMID: 19474802
    50. PAFR is localized in lipid rafts and/or caveolae, a position that is important for proper coupling to downstream signaling elements. PMID: 19620302

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 1 family
  • 组织特异性：
    Expressed in the placenta, lung, left and right heart ventricles, heart atrium, leukocytes and differentiated HL-60 granulocytes.
  • 数据库链接：

    HGNC: 9582

    OMIM: 173393

    KEGG: hsa:5724

    STRING: 9606.ENSP00000301974

    UniGene: Hs.77542