Recombinant Human Natural cytotoxicity triggering receptor 1 (NCR1)

1. this paper shows that the decreased expression of activating receptor NKp46 on peripheral blood NK cells is positively associated with gastric cancer progression PMID: 30255106
2. HIF-1alpha inhibits NCR1/NKp46 pathway through up-regulating miR-224, which affects the killing capability of NK cells on prostate cancer, thus inducing immune escape of tumor cells. PMID: 29885835
3. The s demonstrated that mutant NKp46 W32R is aberrantly glycosylated, accumulates in the endoplasmic reticulum, and is unstable on the cell surface. PMID: 28134248
4. Low NKp46 expression on on NK cells is associated with Nasopharyngeal Carcinoma. PMID: 29580037
5. Signaling via the natural killer cell receptor NKp46 (human) and Ncr1 (mouse) induced interferon-gamma (IFN-gamma) secretion from intratumoral natural killer cells. PMID: 29329948
6. findings show HIV reservoir size is dependent on the presence of a defined NK cell population with a specific transcriptional signature: high NCR (NKp46 and NKp30) and IFN-gamma inducibility upon NCR and cytokine receptor engagement PMID: 28956765
7. NKp46 cleavage by Cathepsin G severely impairs NKp46-mediated responses of Natural killer cells. PMID: 27587403
8. The NKp46 and NKp46-ligand interaction contributes to NK cell activation. PMID: 28328926
9. this study shows that the NKp46-activating receptor recognizes an unknown ligand expressed by human metapneumovirus-infected cells PMID: 28191644
10. Intrahepatic NKp46 NK cells exhibited anti-HCV activity via cell-to-cell contact. The variation of the NKp46 proportion in individuals could be attributed to the diversity of HCV resistance observed in these individuals. PMID: 26714120
11. Taken together, these results demonstrate that endogenous levels of IFN-alpha secreted by plasmacytoid dendritic cells induce natural killer cells to lyse HIV-1-infected autologous CD4+ primary T cells via the engagement of NKp46 and NKG2D. PMID: 26372382
12. NKp46 was thus involved in the production of serine proteases and interleukin-22 in human mast cells. PMID: 25940096
13. Age and CMV serostatus influence the expression of NKp30, NKp46 and DNAM-1 activating receptors on resting and IL-2 activated natural killer cells. PMID: 25991472
14. Ncr1-Noe proteins accumulate in the endoplasmic reticulum, and that the expression of Ncr1-Noe proteins, but not WT Ncr1, leads to increased Helios expression PMID: 26371250
15. Data show that regulatory dendritic cells (regDC) restrain IFN-gamma secretion by NK cells through secretion of interleukin-10 (IL-10), engagement of MHC class I-specific inhibitory receptors, and the activating receptor NKp46. PMID: 26232426
16. Expression of NKp46/NCR1 in NK cells was significantly higher in untreated severe aplastic anemia patients than those in remission SAA and controls. This may be the reason for the hyperfunction of the immune system in SAA patients. PMID: 26554241
17. Downregulated NKG2D, NKp46, and DNAM-1 receptors associated with impaired NK cell effector function are important biomarkers of advanced disease with a poor prognosis in melanoma patients. PMID: 24769842
18. Women, w/ or w/o endometriosis, having larger populations of cytotoxic CD16(+) uterine NK cells and/or higher populations of NKp46(+)CD56(+) cells may be at greater risk of infertility resulting from inflammatory environment during implantation or later PMID: 24807109
19. IL-15+IL-12 has an immunomodulatory effect on NK cell subsets from HIV-infected individuals viz down-regulation of iNKRs, elevation of activatory receptors NKp46 and NKG2D, and induction of coreceptor NKp80. PMID: 22715368
20. NKp46 marks out pathologically activated natural killer cells, which may result from a loss of homeostatic control of activating receptor expression in hepatitis C virus. PMID: 23665989
21. NKp46 is expressed on CD4 lymphocytes in mycosis fungoides and Sezary syndrome. PMID: 23900021
22. Cytokine stimulation combined with natural killer cell receptor engagement are required for human natural killer cell functional diversity. PMID: 23490421
23. involved in cytokine production of CD56+ NK cells in the uterine endometrium PMID: 23311919
24. PLS3, Twist, KIR3DL2 and NKp46 gene expression can model efficient molecular Sezary syndrome diagnosis. PMID: 23429988
25. NKp46 expression of hepatitis C virus replication controls the modulation of liver fibrosis. PMID: 22532190
26. Race and gender related variation found in NKp46 receptor expression with differential anti-hepatitis C virus immunity. PMID: 22505144
27. expressed in all investigated cases of transformed mycosis fungoides PMID: 22621189
28. We suggest that NKp46 dimerization contributes to NKp46-mediated lysis by NK cells. PMID: 22615207
29. NKp46 levels remain stable on the natural killer cells that persist at one week post-liver transplant in pediatric patients. PMID: 22360401
30. important role in inhibition of liver fibrosis PMID: 22198715
31. This study demonistrated that NCR1 expression on astrocytes in MS tissue. PMID: 22212381
32. Role of runt-related transcription factor 3 (RUNX3) in transcription regulation of natural cytotoxicity receptor 1 (NCR1/NKp46), an activating natural killer (NK) cell receptor. PMID: 22253448
33. findings show that NK cells can significantly accelerate neutrophil apoptosis, and that this process is dependent on cell-cell contact and mediated by the activating NK cell receptor NKp46 and the Fas pathway PMID: 22231698
34. decreased expression is associated with altered NK-cell function in pediatric transplant patients with PTLD PMID: 22105417
35. we investigate whether NKp46 is involved in the killing of human beta cells PMID: 21849674
36. NKp46 identifies a functionally distinct NKT subset in that appears to be directly susceptible to leukemic transformation when IL-15 is overexpressed. PMID: 21364281
37. Data show that an increase in 2B4-expressing NK cells and a decrease in NKp46(+) NK cells occurred following intramuscular influenza vaccination. PMID: 21214542
38. peripheral blood malignant CD4(+) T lymphocytes from patients with Sezary syndrome, an aggressive form of cutaneous T-cell lymphoma, express NKp46 at their cell surface PMID: 21191411
39. NKp46 interacts with heparin and heparan sulfate, highly sulfated glycans, and multimeric alpha2,3-NeuAc-containing N-glycan; these glycans interact mainly with basic amino acids in NKp46. PMID: 21329668
40. Data show that only NKp46 appeared involved in the NK response. PMID: 21030563
41. NKp46 is essential for the development of type 1 diabetes PMID: 20023661
42. The NKp46 receptor participates in NK cell-mediated lysis of cells infected with the intracellular pathogen Mycobacterium tuberculosis, an activity that is reduced in tuberculosis patients compared with findings in healthy donors. PMID: 11907104
43. crystal structure of the human natural killer (NK) cell activating receptor NKp46 PMID: 12960161
44. NKp46 interacts with both viral hemagglutinins and the unknown tumor ligands via different mechanisms. PMID: 14504081
45. CD59 is physically associated with NKp46 and NKp30 and activate human nk cell-mediated cytotoxicity. PMID: 14635045
46. natural cytotoxicity receptor (NCR) and NK receptor member D of the lectin-like receptor family (NKG2D) were the key NK activating receptors for bone marrow-derived myeloma cell recognition PMID: 15328155
47. NKp46 is not only a triggering molecule essential for antitumor activity but is also a surface receptor involved in natural killer cell suicide. PMID: 15728472
48. Results examine residues in NKp46 that may be involved in heparan sulfate binding on tumor cells. PMID: 16262248
49. defect in cytotoxic effector function is associated with a reduced surface expression of activating NK receptors (NKp30, NKp46, and NKG2D) on CD56(dim) NK cells compared with uninfected newborns. PMID: 16690951
50. The natural cytotoxicity receptor NKp46 was required for the killing of all myeloma cell lines analyzed. PMID: 17875681

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HGNC: 6731

OMIM: 604530

KEGG: hsa:9437

STRING: 9606.ENSP00000291890

UniGene: Hs.97084