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  4. Recombinant Human Membrane-associated progesterone receptor component 1 (PGRMC1)

Recombinant Human Membrane-associated progesterone receptor component 1 (PGRMC1)

  • 货号：
    CSB-CF017876HU
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
    PGRMC1
  • Uniprot No.：
  • 别名：
    PGRMC1; HPR6.6; PGRMC; Membrane-associated progesterone receptor component 1; mPR; Dap1; IZA
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    2-195
  • 氨基酸序列
    AAEDVVATGADPSDLESGGLLHEIFTSPLNLLLLGLCIFLLYKIVRGDQPAASGDSDDDEPPPLPRLKRRDFTPAELRRFDGVQDPRILMAINGKVFDVTKGRKFYGPEGPYGVFAGRDASRGLATFCLDKEALKDEYDDLSDLTAAQQETLSDWESQFTFKYHHVGKLLKEGEEPTVYSDEEEPKDESARKND
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Component of a progesterone-binding protein complex. Binds progesterone. Has many reported cellular functions (heme homeostasis, interaction with CYPs). Required for the maintenance of uterine histoarchitecture and normal female reproductive lifespan. Intracellular heme chaperone. Regulates heme synthesis via interactions with FECH and acts as a heme donor for at least some hemoproteins.
  • 基因功能参考文献：
    1. High PGRMC1 expression is associated with renal cell carcinoma. PMID: 30015972
    2. Down-regulation of PGRMC1 was associated with poor tumor differentiation and worse patient survival in hepatocellular carcinoma. PMID: 29563759
    3. These new findings demonstrate that PGRMC1 might play an important role in progression and therapy resistance of human breast tumors and could offer an interesting target for anticancer therapy. PMID: 28701017
    4. Cystathionine beta-synthase and PGRMC1 function as carbon monoxide sensors in health and disease. (Review) PMID: 27565814
    5. Sigma-2 receptor and PGRMC1 are not identical. PMID: 28007569
    6. Report a dynamic pattern of PGRMC1 and SERBP1 expression in human endometrium throughout the menstrual cycle and highlight a putative novel implication of PGRMC1 in the human decidualization process. PMID: 28911927
    7. Progesterone, Inflammatory Cytokine (TNF-alpha), and Oxidative Stress (H2O2) Regulate Progesterone Receptor Membrane Component 1 (PGRMC1) Expression in Fetal Membrane Cells. Study concludes that these stimuli act as regulatory factors of PGRMC1 in a cell-specific manner. PMID: 26919974
    8. findings demonstrate PGRMC1, which promotes RCC progression phenotypes in vitro and in vivo, is a novel potential biomarker and therapeutic target for RCC PMID: 28107520
    9. Data suggest that PGRMC1 plays important roles in synthesis of cholesterol and steroids and in energy regulation. [REVIEW] PMID: 28104494
    10. data illustrate a role for PGRMC1 in regulating heme synthesis via interactions with FECH and suggest that PGRMC1 may be a heme chaperone or sensor PMID: 27599036
    11. The effects of progesterone treatment on the expression levels of progesterone receptor membrane component 1 (PGRMC1), plasminogen activator inhibitor 1 RNA-binding protein (PAIRBP1), and progestin and adipoQ receptor 7 (PAQR7) on both mRNA and protein levels were investigated in spheroids derived from human glioma cell lines U-87 MG and LN-229. PMID: 27340667
    12. It can be suggested that women with breast epithelium highly expressing PGRMC1 and in interaction with ERalpha may have an increased risk to develop breast cancer. PMID: 26303031
    13. These results clarify that PGRMC1 and the S2R are distinct binding sites expressed by different genes. PMID: 26870805
    14. Haem-mediated PGRMC1 dimerization is required for interactions with EGFR and cytochromes P450, cancer proliferation and chemoresistance against anti-cancer drugs. PMID: 26988023
    15. indicate that PGRMC1 regulates hepcidin gene expression through an evolutionarily conserved mechanism PMID: 26657863
    16. results suggested that PGRMC1 and sigma2 receptors are two different molecular entities. PMID: 25843410
    17. PGRMC1 is the major progesterone receptor eliciting the protective effects of Norgestrel, a synthetic female progesterone hormone. PMID: 26447367
    18. coding mutations of PGRMC1 do not seem to be a common cause of the disease in Han Chinese PMID: 25246111
    19. PGRMC1 overexpression led to the epithelial-mesenchymal transition and chemoresistance in uterine sarcoma. PMID: 25596698
    20. progesterone binds to hPGRMC1 and introduces spectral changes that manifest conformational changes to the heme. PMID: 25675345
    21. Loss of PGRMC1 expression is associated with endometrial tumor cell viability during chemotherapeutic stress. PMID: 25304370
    22. PGRMC1 binds to key components of the autophagy machinery and is required for the degradative activity of autophagy PMID: 24113030
    23. PGRMC1 expression appears to be diminished in pregnant women with preterm premature rupture of the membranes. PMID: 24680695
    24. PGRMC-1 expression is downregulated in the endometria from women with advanced stage endometriosis. PMID: 23793472
    25. In a chorion cell line, PGRMC1 mediates the effects of progestins on matrix metalloproteinase 9 activity. PMID: 23813454
    26. PGRMC1 can act as an adaptor protein for multiple classes of steroid receptors PMID: 24424068
    27. ABHD5, PGRMC1 and SQS are novel markers for sebaceous carcinoma and can reliably distinguish sebaceous neoplasms from non-sebaceous tumors, specifically BCC with clear cell features. PMID: 23557589
    28. The expression of PGRMC1 is strongly associated with the progression of breast cancer. PMID: 22588913
    29. Data suggest that women with breast cells overexpressing PGRMC1 have higher risk of breast cancer when treated with progestins (as in some hormonal contraceptives). PMID: 23116217
    30. miR-98 and miR-181a through their regulatory functions on PGRMC1, PGR, CYP19A1, TIMP3, and DDX3X expression may influence a wide range of endometrial cellular activities during normal menstrual cycle and transition into disease states. PMID: 22492871
    31. Pgrmc1 localizes to secretory vesicles in cancer cells, and Pgrmc1 was secreted by lung cancer cells. Furthermore, Pgrmc1 was significantly elevated in the plasma of lung cancer patients compared to noncancer patients. PMID: 21918976
    32. PGRMC1 negatively modulates the drug-metabolizing activities of P450. PMID: 21825115
    33. In patients with elevated PGRMC1 mRNA levels, gonadotropin-induced follicle development is attenuated, although sufficient numbers of follicles develop to allow for embryo and subsequent pregnancy. PMID: 22245528
    34. roles of progesterone (P4) and Progesterone Receptor Membrane Component 1 (PGRMC1) in regulating mitosis of ovarian cancer cells, SKOV-3. P4's actions appear to be dependent on PGRMC1's function within the mitotic spindle. PMID: 21148105
    35. Expression of PGRMC1 mRNAs was significantly lower in JEG-3 cells compared to non-syncytialized BeWo cells. PMID: 21455559
    36. PGRMC1 is lower in myometrium of women at term either not in labour (P = 0.004) or in labour (P = 0.005) compared with tissues from women in preterm non-labour. PMID: 21131300
    37. we propose that PGRMC1 expression is regulated by the miRNAs let-7/miR-98 PMID: 21109987
    38. Reduced levels of PGRMC1 in peripheral leukocytes are associated with perturbed ovulatory function. PMID: 20537145
    39. Pgrmc1 associates with epidermal growth factor receptor and regulates erlotinib sensitivity PMID: 20538600
    40. increases in vivo tumor growth, anchorage-independent growth, and migration PMID: 20164297
    41. Hpr6.6 regulates cell death through a novel oxidative damage response pathway. PMID: 14523988
    42. The expression of a novel progesterone-binding protein (hmPR2/PGMRC2) was investigated. Transcripts of this protein have been detected in human sperm. PMID: 15702432
    43. Hpr6 homologues regulate cytochrome P450 proteins implicated in hormone, steroid and xenobiotic chemical metabolism; Hpr6 expression linked to cancer progression and cellular survival PMID: 15970648
    44. Our findings support a model in which Hpr6 binds to heme and regulates susceptibility to damaging agents PMID: 16234411
    45. These findings demonstrate that PGRMC1 is required for P450 activity and suggest that interindividual variation in PGRMC1 function may impact multiple biochemical pathways and drug metabolism. PMID: 17276356
    46. PGRMC1 may be involved in sterol metabolism or homeostasis and cell survival [review] PMID: 18249431
    47. PGRMC1 plays an important role in promoting ovarian cancer cell viability and that attenuating PGRMC1's action makes the ovarian cancer cells more sensitive to cisplatin. PMID: 18319313
    48. The aim of this study was to assess the expression, localization and hormonal regulation of two novel P(4) receptor candidates, P(4) receptor membrane component (PGRMC) 1 and PGRMC2, as well as the PGRMC1 partner Serpine 1 mRNA binding protein (SERBP1). PMID: 18440126
    49. The results demonstrate the first demonstration of mPR expression in human epithelial ovarian tumors. PMID: 18479732
    50. These findings suggest that mutant or reduced levels of PGMRC1 may cause premature ovarian failure through impaired activation of the microsomal cytochrome P450 and increased apoptosis of ovarian cells. PMID: 18782852

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  • 亚细胞定位：
    Microsome membrane; Single-pass membrane protein. Smooth endoplasmic reticulum membrane; Single-pass membrane protein. Mitochondrion outer membrane; Single-pass membrane protein; Extracellular side.
  • 蛋白家族：
    Cytochrome b5 family, MAPR subfamily
  • 组织特异性：
    Widely expressed, with highest expression in liver and kidney. Expressed by endometrial glands and stroma (at protein level).
  • 数据库链接：

    HGNC: 16090

    OMIM: 300435

    KEGG: hsa:10857

    STRING: 9606.ENSP00000217971

    UniGene: Hs.90061