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  4. Recombinant Human Killer cell immunoglobulin-like receptor 3DL1 (KIR3DL1)

Recombinant Human Killer cell immunoglobulin-like receptor 3DL1 (KIR3DL1)

  • 货号：
    CSB-CF012364HU
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
  • Uniprot No.：
  • 别名：
    KIR3DL1; CD158E; NKAT3; NKB1; Killer cell immunoglobulin-like receptor 3DL1; CD158 antigen-like family member E; HLA-BW4-specific inhibitory NK cell receptor; MHC class I NK cell receptor; Natural killer-associated transcript 3; NKAT-3; p70 natural killer cell receptor clones CL-2/CL-11; p70 NK receptor CL-2/CL-11; CD antigen CD158e
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    22-444
  • 氨基酸序列
    HMGGQDKPFLSAWPSAVVPRGGHVTLRCHYRHRFNNFMLYKEDRIHIPIFHGRIFQESFNMSPVTTAHAGNYTCRGSHPHSPTGWSAPSNPVVIMVTGNHRKPSLLAHPGPLVKSGERVILQCWSDIMFEHFFLHKEGISKDPSRLVGQIHDGVSKANFSIGPMMLALAGTYRCYGSVTHTPYQLSAPSDPLDIVVTGPYEKPSLSAQPGPKVQAGESVTLSCSSRSSYDMYHLSREGGAHERRLPAVRKVNRTFQADFPLGPATHGGTYRCFGSFRHSPYEWSDPSDPLLVSVTGNPSSSWPSPTEPSSKSGNPRHLHILIGTSVVIILFILLLFFLLHLWCSNKKNAAVMDQEPAGNRTANSEDSDEQDPEEVTYAQLDHCVFTQRKITRPSQRPKTPPTDTILYTELPNAKPRSKVVSCP
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Receptor on natural killer (NK) cells for HLA Bw4 allele. Inhibits the activity of NK cells thus preventing cell lysis.
  • 基因功能参考文献：
    1. human leukocyte antigen (HLA)-Bw4 is associated with susceptibility to psoriatic disease (PsD), but genetic interactions with their cognate ligand, variably expressed killer cell immunoglobulin like receptor (KIR) 3DL1 alleles PMID: 28801811
    2. HLA-Bw4-80(T) and multiple HLA-Bw4 copies in combination with KIR3DL1 are associated with protection against chronic hepatitis C in people who inject drugs by distinct mechanisms. PMID: 28412292
    3. Higher proportion of NK cells expressing inhibitory CD158b and CD158e receptors is associated with significant liver injury in children with chronic hepatitis C. PMID: 28611271
    4. KIR3DL1*0010101 and low mRNA expression is associated with antibody mediated acute rejection and chronic rejection. PMID: 28942035
    5. This study suggests a possible role of killer cell immunoglobulin-like receptors and their ligands in the development of liver damage. The absence of human leucocyte antigen C1 and C2 ligands heterozygosity could lead to less inhibition of natural killer cells and a quicker progression to a high level of fibrosis in patients infected with hepatitis C virus, especially following liver transplantation. PMID: 26717049
    6. KIR loci in terms of copy number and haplotypes are not likely to play a major role in antibody response to measles vaccination. PMID: 28158231
    7. Among 11 discovered KIR genotypes, 6 genotypes showed a considerable role and 4 genotypes could preclude the risk of systemic sclerosis (SSc) disease. significant confounding effects were seen between involved genes in these two combinations: "KIR3DL1; HLA-BW4-Thr80" and "KIR3DL1 -HLA-BW4-A1." PMID: 28120169
    8. The present study for the first time presents the beneficial effects of KIR genotype matching in reducing cGVHD in myeloablative transplant setting using HLA matched (sibling and unrelated) donors. The findings offer a clinically applicable donor selection strategy that can help control cGVHD without affecting the risk of relapse and/or identify patients at a high risk of developing cGVHD PMID: 27341514
    9. the KIR3DL1*001, *005, and *015 polymorphisms are remote from the KIR3DL1-HLA-I interface, the structures of these three KIR3DL1-HLA-I complexes showed that the broader HLA-I specificity of KIR3DL1*005 correlated with an altered KIR3DL1*005 interdomain positioning and increased mobility within its ligand-binding site. PMID: 27045007
    10. evidence that KIR-regulated signaling contributes to Behcet's disease PMID: 27708262
    11. KIR3DL1 in combination with HLA-A and -B alleles bearing the Bw4 motif show strong protective effect against multiple sclerosis in African Americans. PMID: 26866467
    12. s results suggest that low cell-surface expression of KIR3DL1 in the presence of the HLA-Bw4 epitope is associated with an increased risk for developing psoriasis. PMID: 26286807
    13. Using depletion studies and Killer immunoglobulin-like receptors-transfected cell lines, demonstrated that the dengue virus NS1 tetramer bound the inhibitory receptor KIR3DL1. PMID: 26439909
    14. KIR3DL1 interaction with HLA-B27 is altered by ankylosing spondylitis associated ERAP1 and enhanced by MHC class I cross-linking PMID: 26321090
    15. In early axial spondyloarthritis and ankylosing spondylitis Dutch patients, no copy number changes were found for KIR3DL1. PMID: 25940819
    16. KIR3DL1 has a protective effect against the more severe manifestations of ankylosing spondylitis. PMID: 26238044
    17. Individuals who carried both KIR3DS1 and Bw4*80I did not remain HIV seronegative longer than those from a control group who were homozygous for HLA-Bw6 and carried no HLA-A locus Bw4 alleles PMID: 25330014
    18. Protective genotypes in HIV infection reflect superior function of KIR3DS1 over KIR3DL1-expressing CD8+ T cells. PMID: 25112829
    19. KIR3DL1-HLA-Bw4 combination and IL28B polymorphism predict response to Peg-IFN and ribavirin with and without telaprevir in chronic hepatitis C patients. PMID: 24929144
    20. the strict conformation of HLA-Bw4 allotypes, held in place by the Glu(76)-Arg(83) interaction, facilitates KIR3DL1 binding, whereas Bw6 allotypes present a platform on the alpha1 helix that is less permissive for KIR3DL1 binding. PMID: 25480565
    21. HIV protective KIR3DL1/S1-HLA-B genotypes influence NK cell-mediated inhibition of HIV replication in autologous CD4 targets. PMID: 24453969
    22. The frequency of KIR3DL1 with HLA-Bw4 was significantly lower in diffuse large B-cell lymphoma patients than in controls. PMID: 24755352
    23. Characterizing Maori and Polynesians is a paucity of HLA-B allotypes recognized by KIR. PMID: 25139336
    24. KIR3DL1 genetic diversity in the Chinese Han population and it's mRNA expression pattern PMID: 24173144
    25. Different KIR3DS1, KIR3DL1 and HLA-Bw4 genotypes and levels of transcripts associate with HIV disease progression. PMID: 24059286
    26. Data indicate the impact of KIR3DL1 polymorphism on peptide-laden HLA recognition. PMID: 24563253
    27. The results of this study found that specific combinations of KIR and their HLA ligands can be either risk factors or protective for immune responses triggering Guillain-Barre Syndrome. PMID: 24367901
    28. HLA-B alleles carrying Bw4 epitope present the highest capability of interaction with KIR3DL1 *001 compared to the HLA-B alleles presenting Bw6. PMID: 23984333
    29. present work has shown that IL-2 and IL-15, cytokines critical for NK cell development and maintenance, greatly stimulate KIR3DL1 reverse promoter activity, but not forward promoter activity PMID: 23328843
    30. Both the nature of KIR3DL1 alleles and the KIR3DL1/S1 allele combination affect the KIR3DL1 NK-cell repertoire in the French population. PMID: 23436464
    31. Report reliable and accurate method for genotyping KIR3DL1/S1 using DNA recovered from plasma. PMID: 23524032
    32. Our data suggest a possible association of KIR/HLA variants and the severity of Gaucher disease. PMID: 23266622
    33. Increased matching between expressed KIR-3DL1 and its ligand HLA-Bw4 was found in Italian patients with paroxysmal nocturnal haemoglobinuria. PMID: 22803950
    34. results show that immunogenetic factors, such as the KIR gene profile, can play a role in tyrosine kinase inhibitor therapy response PMID: 22842045
    35. structure of a human KIR3DL1 receptor bound to HLA-B*5701 complexed with a self-peptide PMID: 22020283
    36. the pattern of inhibitory/activating KIR genes, together with their HLA ligands, is associated with susceptibility to B-cell chronic lymphocytic leukemia and affects the clinical course of this disease PMID: 21726204
    37. KIR3DL1 gene expression is upregulated in intestinal mucosa in active celiac disease. PMID: 21616111
    38. The first Ig domain of KIR3DL1 contacts MHC class I at a secondary site. PMID: 21746965
    39. In this review, KIR3DL1/S1 is described as the most extensively studied of the variable natural killer (NK) cell receptors, exemplifying how variation in all possible parameters of function is recruited to diversify the human NK cell response. PMID: 21690332
    40. The less the KIR/HLA-Cw matched, the more cytotoxic activity was shown in NK cells. PMID: 19549379
    41. Enhanced NK polyfunctionality in HIV slow progressors was dependent upon the coexpression of both KIR3DL1*h/*y and HLA-B*57. PMID: 21471235
    42. Distinct HIV-1 epitopes differentially modulated the binding of KIR3DL1 to HLA-Bw4. PMID: 21471246
    43. It was observed that the Thai population shows polymorphism of the KIR genes and the diversities of KIR genes in Thai differed from other populations. PMID: 21696085
    44. analysis of evolution in the centromeric and telomeric regions of group A and B haplotypes of the human killer cell Ig-like receptor locus PMID: 21206914
    45. genetic polymorphism contributes to pathogenesis of ankylosing spondylitis PMID: 20652381
    46. This finding indicates that the inhibitory KIR3DL1 receptor protects against the development of ankylosing spondylitis and is not simply a passive counterpart of the segregating KIR3DS1 allele encoding the activating receptor. PMID: 20818412
    47. expression levels of KIR3DL1 may be involved in the pathogenesis of ankylosing spondylitis PMID: 20574122
    48. Natural killer (NK) cell receptor KIR3DL1*004 is sequestered in the endoplasmic reticulum of the NK cell where it binds to the chaperone calreticulin and does not induce the unfolded protein response. PMID: 21115737
    49. Results indicate a prominent role for KIR3DL1/HLA-Bw4 interactions in licensing natural killer cells for CD16-mediated effector function. PMID: 20664023
    50. KIR3DL1 and KIR3DS1 allele frequencies were determined by DNA sequencing of the complete coding regions from 100 random unrelated African Americans PMID: 20230527

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  • 亚细胞定位：
    Cell membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Immunoglobulin superfamily
  • 数据库链接：

    HGNC: 6338

    OMIM: 604946

    KEGG: hsa:3811

    STRING: 9606.ENSP00000375608

    UniGene: Hs.645228