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  4. Recombinant Human Killer cell immunoglobulin-like receptor 2DL3 (KIR2DL3)

Recombinant Human Killer cell immunoglobulin-like receptor 2DL3 (KIR2DL3)

  • 货号：
    CSB-CF012354HU
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
  • Uniprot No.：
  • 别名：
    KIR2DL3; CD158B2; KIRCL23; NKAT2; Killer cell immunoglobulin-like receptor 2DL3; CD158 antigen-like family member B2; KIR-023GB; Killer inhibitory receptor cl 2-3; MHC class I NK cell receptor; NKAT2a; NKAT2b; Natural killer-associated transcript 2; NKAT-2; p58 natural killer cell receptor clone CL-6; p58 NK receptor CL-6; p58.2 MHC class-I-specific NK receptor; CD antigen CD158b2
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    22-341
  • 氨基酸序列
    HEGVHRKPSLLAHPGPLVKSEETVILQCWSDVRFQHFLLHREGKFKDTLHLIGEHHDGVSKANFSIGPMMQDLAGTYRCYGSVTHSPYQLSAPSDPLDIVITGLYEKPSLSAQPGPTVLAGESVTLSCSSRSSYDMYHLSREGEAHERRFSAGPKVNGTFQADFPLGPATHGGTYRCFGSFRDSPYEWSNSSDPLLVSVTGNPSNSWPSPTEPSSETGNPRHLHVLIGTSVVIILFILLLFFLLHRWCCNKKNAVVMDQEPAGNRTVNREDSDEQDPQEVTYAQLNHCVFTQRKITRPSQRPKTPPTDIIVYTELPNAEP
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Receptor on natural killer (NK) cells for HLA-C alleles (HLA-Cw1, HLA-Cw3 and HLA-Cw7). Inhibits the activity of NK cells thus preventing cell lysis.
  • 基因功能参考文献：
    1. These results suggest a detrimental role of HLA-A-Bw4 and HLA-C2 groups, which are associated with the development of chronic hepatitis B, and a protective role of KIR2DL3. PMID: 28211154
    2. A minority (21%) of HLA-B( *)46:01 peptides, with common C-terminal characteristics, form ligands for KIR2DL3. PMID: 28514659
    3. These results show that 2DL3(+) NK cells are mediators of HIV-specific responses. Furthermore, responses of NK cell populations to iCD4 are influenced not only by NK cell education through specific KIR/HLA pairs, but also by differential HIV-mediated changes in HLA expression. PMID: 27506421
    4. Results identified three SNPs (S320F, H245Y, and H77Y) as highly deleterious in KIR2DL3 and nine SNPs (R157Q, H156Y, S63L, R157 W, F179 V, H128R, T101 M, R180C and F176I) in case of IFNL3, in coding region only with high conservation ranks highlighting the functional SNPs on phenotypic variability and disease susceptibility on HCV clearance candidate genes. PMID: 27461217
    5. gene polymorphism is associated with Crohn's disease in Spanish patients PMID: 26542067
    6. study compared KIR gene repertoire of HIV-1 positive with exposed uninfected (EU)) infants to elucidate its association with transmission; results revealed presence of significantly high frequencies of activating gene KIR 2DS5 and inhibitory gene KIR 2DL3 in EU infants as compared to HIV-1 positive infants PMID: 26255774
    7. The s have identified a deleterious effect of the KIR2DL3-HLA-C1 receptor-ligand combination on HIV clinical outcomes in a Thai cohort. PMID: 26372271
    8. Single Nucleotide Polymorphism in KIR2DL3 gene is associated with Asthma and Atopic Dermatitis. PMID: 26430804
    9. KIR2DL3 has previously been identified as important for clearance of the Hepatitis C virus after established infection,not found to be relevant to resistance to Hepatitis C infection. PMID: 24845613
    10. CD4(+) CD28(-) cells exhibited increased KIR2DS2, reduced KIR2DL3 and increased DAP12 expression in HD-ESRD compared with NDD-CKD patients. PMID: 25484131
    11. KIR2DL3 and KIR3DS1 genes could be protector genes and immuno-genetic markers for Hepatits B in the Turkish population. PMID: 24407110
    12. Higher frequency of CD158b+ natural killer cells combined with fewer activated NK cells may be associated with HCV-related chronic inflammation. PMID: 23813131
    13. Low frequency of KIR2DL3 is associated with nodular melanoma and in ulcerated melanoma. PMID: 23370861
    14. Gene frequency of KIR2DL3 is lower in subjects with rheumatoid arthritis than in control. PMID: 22960345
    15. Our study indicates that the absence of the inhibitory KIR2DL3 gene is associated with an increased risk of developing multiple sclerosis in individuals carrying HLA-C1 alleles PMID: 22185807
    16. Substitutions restricted to activating KIR all reduce the avidity of KIR2DL1 and KIR2DL3, further evidence that activating KIR function often becomes subject to selective attenuation. PMID: 22772445
    17. These results suggest that natural selection has reduced the frequency of the KIR2DL3-HLA-C1 combination in malaria high-endemic population. PMID: 22412373
    18. We found an increase in the KIR A haplotype in tuberculosis patients compared to controls, and only KIR 2DL3 was found to be significantly more prevalent among TB patients PMID: 22118180
    19. KIR2DL3, KIR2DS5 and KIR2DL5B genes may be correlated with pathogenesis of nasopharyngeal carcinoma in the Chinese southern Han population. PMID: 21729574
    20. Carriage of specific KIR genes in combination with specific HLA-C and IL28B variants was associated with an altered HCV treatment response. PMID: 21931540
    21. indicated nonspecific stimulation of natural killers, probably mediated by an increase in serum concentration of heat shock protein with a molecular weight of 70 kDa PMID: 21165439
    22. Data shoe that KIR2DL3-C1C2 combination was near-significantly associated with HAM/TSP outcome in the second stage. PMID: 20483367
    23. Despite its particular monoclonal antibody reactivity, the specificity of KIR2DL3*005 for HLA-C molecules does not differ from that of other KIR2DL2/L3 alleles. PMID: 20525888
    24. decidual CD4+ and CD8+ T cells contain increased proportions of KIR2DL3+ cells compared to peripheral blood PMID: 19394706
    25. KIR and HLA-C protection in both treatment response and spontaneously resolving HCV was validated at the allelic level, in which KIR2DL3-HLA-Cw*03 was associated with sustained virological response (SVR)(P = 0.004, OR = 3.4, 95% CI = 1.5-8.7). PMID: 20077564
    26. HLA-Cw7 zygosity affects the size of a subset of CD158b+ natural killer cells. PMID: 11958591
    27. Positive linkage disequilibrium was seen between KRI2DL1 and KIR2DL3.Individuals were subgrouped according to the major HLA-C encoded KIR-epitopes (group C1 versus C2). C2 individuals transcribe RNA from KIR2DL2 genes without specific HLA-C ligands. PMID: 12559621
    28. Decreased expression of NKB1 and GL183 on natural killer (NK) cells in endometrium, but not in myometrium, in women with adenomyosis. May be compensatory effect in which NK cytotoxicity is activated to eradicate abnormal endometrial cells. (GL183) PMID: 15217996
    29. The modulated expression of KIR by IL-2 and TGF-beta can be associated with the changed NK-cytotoxic target-discriminating ability of NK cells upon their exposure to IL-2 and TGF-beta. PMID: 15227739
    30. results show that genes encoding the inhibitory NK cell receptor KIR2DL3 and its human leukocyte antigen C group 1 (HLA-C1) ligand directly influence resolution of hepatitis C virus (HCV) infection PMID: 15297676
    31. donor killer immunoglobulin-like receptor (KIR) genotype-patient KIR ligand combination (Mismatch) and no antithymocyte globulin preadministration are critical factors for the adverse effects of allogeneic stem cell transplantation PMID: 18158964
    32. In contrast to natural killer (NK) cells, the functions of killer inhibitory receptors in CD4+ T lymphocytes might derive from a selective expression of their activating or inhibiting (CD158b2) forms. PMID: 18292496
    33. Allelic polymorphism at sites distal to the ligand-binding site of KIR2DL3 has diversified this receptor's interactions with HLA-C. No cytotoxic interaction between the HLA-C epitope and KIR2DL3 receptor is observed compared to that of KIR2DL2 and HLA-C. PMID: 18322206
    34. Some KIR-HLA genotypes could be associated to the development of clinical forms of leprosy. PMID: 18778326
    35. Support role for KIR2DL3 receptor in determining severity of hepatitis C virus recurrence after liver transplantation. PMID: 19326408
    36. This study provides an estimate of the minimal KIR-HLA system essential for long-term survival of a human population. PMID: 19837691

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  • 亚细胞定位：
    Cell membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Immunoglobulin superfamily
  • 数据库链接：

    HGNC: 6331

    OMIM: 604938

    KEGG: hsa:3804

    STRING: 9606.ENSP00000342215

    UniGene: Hs.654608