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  4. Recombinant Human Killer cell immunoglobulin-like receptor 2DL2 (KIR2DL2)

Recombinant Human Killer cell immunoglobulin-like receptor 2DL2 (KIR2DL2)

  • 货号：
    CSB-CF012353HU
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
  • Uniprot No.：
  • 别名：
    KIR2DL2; CD158B1; NKAT6; Killer cell immunoglobulin-like receptor 2DL2; CD158 antigen-like family member B1; MHC class I NK cell receptor; Natural killer-associated transcript 6; NKAT-6; p58 natural killer cell receptor clone CL-43; p58 NK receptor CL-43; CD antigen CD158b1
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    22-348
  • 氨基酸序列
    HEGVHRKPSLLAHPGRLVKSEETVILQCWSDVRFEHFLLHREGKFKDTLHLIGEHHDGVSKANFSIGPMMQDLAGTYRCYGSVTHSPYQLSAPSDPLDIVITGLYEKPSLSAQPGPTVLAGESVTLSCSSRSSYDMYHLSREGEAHECRFSAGPKVNGTFQADFPLGPATHGGTYRCFGSFRDSPYEWSNSSDPLLVSVIGNPSNSWPSPTEPSSKTGNPRHLHILIGTSVVIILFILLFFLLHRWCSNKKNAAVMDQESAGNRTANSEDSDEQDPQEVTYTQLNHCVFTQRKITRPSQRPKTPPTDIIVYAELPNAESRSKVVSCP
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Receptor on natural killer (NK) cells for HLA-Cw1, 3, 7, and 8 allotypes. Inhibits the activity of NK cells thus preventing cell lysis.
  • 基因功能参考文献：
    1. Killer cell immunoglobulin like receptor two (KIR2DL2) shows a risk association with Chinese Han hepatitis C virus-1b (HCV-1b) patients not responding to the combination therapy of pegylated alpha interferon (PEG-IFN) with ribavirin (RBV). PMID: 30039498
    2. KIR2DL2/HLA-C( *)12:02 and KIR2DL2/HLA-C( *)14:03 compound genotypes have protective effects on control of HIV-1. PMID: 27880898
    3. KIR2DL2 gene polymorphism is associated with HIV-1 infection. PMID: 26888639
    4. association between KIR2DS2 and the response to methotrexate (MTX), moreover, the combination KIR2DL2+/KIR2DS2+ was more frequent in responders to MTX (p = 0.043). PMID: 27251940
    5. KIR2DL2/KIR2DL3-glutamate(35) alleles are functionally stronger than -glutamine(35) alleles. PMID: 27030405
    6. KIR2DL2/2DS2-C1C1 genotype is associated with type 1 diabetes in Saudi children PMID: 26542066
    7. genetic association study in population in Eastern India: Data suggest that interactions between KIRs (KIR2DL2, KIR2DS4, KIR2DL3) and HLA ligands (HLAC1, HLAC2) contribute significantly toward susceptibility and protection toward type 1 diabetes. PMID: 26031759
    8. Allelic polymorphism of KIR2DL2/2DL3 in a southern Chinese population. PMID: 26423800
    9. a significant increase in the frequency of KIR2DL2 (P = 0.019) as well as KIR2DS2 (P = 0.008) in patients with neuroblastoma compared with the healthy control group, was found. PMID: 26202659
    10. Single Nucleotide Polymorphism in KIR2DL2 gene is associated with Asthma and Atopic Dermatitis. PMID: 26430804
    11. genetic polymorphism is associated with chronic hepatitis C and levels of viremia in Poland PMID: 25636579
    12. KIR2DL2 and KIR2DS2 genotype is associated with protection against primary biliary cirrhosis in Han population. PMID: 25575065
    13. Genetic risk for co-occurrence of type 1 diabetes and celiac disease is modified by HLA-C and killer immunoglobulin-like receptors. PMID: 25329633
    14. s showed an increase in HLA-C1/KIR2DL2 and HLA-C1/KIR2DL3 pairs in human papillomavirus high-risk infected patients (OR 3.05, 3.24) with invasive cervical cancer (OR 1.33, 3.68). PMID: 25188020
    15. KIR2DL3-positive NK cells were more sensitive to changes in the peptide content of MHC class I than KIR2DL2-positive NK cells. PMID: 25359276
    16. s showed a significant increased correlation between KIR2DL2/DS2, type 2 diabetes and HLA-C1C1 genotype in the type 2 diabetes patients infected with human herpesvirus 8. PMID: 24122895
    17. these results suggest that inhibitory KIR2DL2 and KIR2DL3, which are alleles of the same locus, play a role in the inverse effects on PM and PM/HIV co-infection PMID: 22715396
    18. These data show that naturally occurring sequence variations within HLA-C03:04-restricted HIV-1 p24 Gag epitopes can have a significant impact on the binding of inhibitory KIR2DL2 receptors and primary natural killer cell function. PMID: 24785948
    19. The strongest association for the development of epithelial ovarian cancer has been found between KIR2DL2 and HLA-C1 expression. PMID: 24755350
    20. HLA-C genotypes are important determinants of conjunctival scarring in trachoma and that KIR2DL2/KIR2DL3 heterozygosity further increases risk of conjunctival scarring in individuals carrying HLA-C2. PMID: 24651768
    21. combinations of KIR3DL1/HLA-Bw4, KIR2DL2/HLA-C1, and a genetic variant of the IL28B gene are predictive of the response to PEG-IFN and ribavirin therapy in Japanese patients infected with genotype 1b HCV. PMID: 24349500
    22. The results of this study confirmed a possible effect of KIR2DL2 on viral infection susceptibility in multiple sclerosis patients. PMID: 24735502
    23. Different expression levels of KIR2DL2 may contribute to the abnormal function of natural killer (NK) and NKT lymphocytes, which lead to the risk of systemic lupus erythematosus (SLE) susceptibility. PMID: 24839813
    24. the most common KIR2DL2/3 allelic products in European American and African American populations were evaluated PMID: 23686481
    25. Data indicate that increased frequency of the activating receptor KIR2DS1 and a reduced frequency of the KIR-ligand combination KIR2DS2/2DL2 absent/C1 present were significantly associated with chronic myeloid leukemia (CML). PMID: 23380384
    26. presence of KIR2DL2 is associated with rheumatoid arthritis. PMID: 22960345
    27. Engagement of KIR2DL2 might protect virus-infected cells from NK cell-mediated lysis and selections of sequence polymorphisms that increase avidity to KIR2DL2 might provide a mechanism for HIV-1 to escape NK cell-mediated immune pressure. PMID: 22807681
    28. individuals possessing KIR2DL2 and/or KIR2DS2 (and, in most cases, also KIR2DL1) gene but no HLA-C C2 ligand may respond better to treatment and survive longer than people bearing other genotypes. PMID: 22836042
    29. KIR2DS2/KIR2DL2 and HLA-C genotype of rheumatoid arthritis patients may provide predictive information for response to anti-TNF-alpha therapy. PMID: 21373785
    30. The results are the first direct proof of the implication of KIR2DL2 receptor in the control of natural killer cell activation towards herpes virus infection in multiple sclerosis. PMID: 22871633
    31. Amino acid variation at positions 68, 70, and 182 modulates the binding avidity of KIR2DL for histocompatibility antigen HLA-C compared to KIR2DL3. PMID: 22772445
    32. In a comparison of healthy controls and a tightly defined cohort of adult ITP patients, the KIR2DS2/KIR2DL2 genotype was found to be associated with ITP independently of FCGR3a-158 polymorphisms. PMID: 22024796
    33. in two unrelated viral infections, hepatitis C virus and human T lymphotropic virus type 1, possession of the KIR2DL2 gene enhanced both protective and detrimental HLA class I-restricted anti-viral immunity. PMID: 22022261
    34. We report four novel KIR2DL2 alleles and two novel KIR2DL3 alleles identified from an East African population using sequence-based typing. PMID: 20875478
    35. Single nucleotide polymorphism in KIR2DL2 gene is associated with posttransplantation non-Hodgkin lymphoma. PMID: 20207982
    36. The KIR2DL2, KIR2DL3 genotype is predisposing to Crohn's disease in the presence of C1 ligand. PMID: 19789864
    37. Absence of KIR2DS2 and/or KIR2DL2 is associated with failure of antiviral therapy in patients with recurrent hepatitis C after liver transplantation PMID: 19877200
    38. Individuals were subgrouped according to the major HLA-C encoded KIR-epitopes (group C1 versus C2). C2 individuals transcribe RNA from KIR2DL2 genes without specific HLA-C ligands. PMID: 12559621
    39. The genetic combination of KIR2DS2+ and KIR2DL2- is associated with scleroderma. PMID: 15146426
    40. KIR2DL2 is positively associated with diabetes mellitus, type 1. PMID: 15699512
    41. Because few factors interfere with the expression of CD158b on natural killer cells, monitoring of this marker may be accurate and sensitive after kidney transplantation. PMID: 15848530
    42. KIRs on memory T cells operate to uncouple effector functions by modifying the transcriptional profile while leaving granule exocytosis unabated. PMID: 16469873
    43. Lack of KIR2DL2 is associated with poor graft function PMID: 17445184
    44. In contrast to natural killer (NK) cells, the functions of killer inhibitory receptors in CD4+ T lymphocytes might derive from a selective expression of their activating or inhibiting (CD158b1) forms. PMID: 18292496
    45. Allelic polymorphism at sites distal to the ligand-binding site of KIR2DL2 has diversified this receptor's interactions with HLA-C; the interaction between the HLA-C epitope and KIR2DL2 strongly inhibits natural killer cell cytotoxicity. PMID: 18322206
    46. Allele typing data support the view that KIR2DL2 and KIR2DL3 are alleles of the same gene. PMID: 18498296
    47. increased frequency in recurrent spontaneous abortion group PMID: 18572300
    48. The role of DNA methylation in regulating of the genes, KIR2DL2 and KIR2DL4, was characterized;these genes are normally suppressed in part by promoter methylation in non-expressing T cells. PMID: 18945643
    49. a combination KIR2DL2- HLA-C1 plays a critical role in susceptibility or protection in Latvians against type 1 diabetes. PMID: 19046302
    50. Natural killer (NK) cells in a humanized mouse model express multiple killer inhibitory receptors in a stochastic manner, including HLA-Cw3-specific inhibitory receptor KIR2DL2; these mice reject wild-type mouse spleen cells upon intravenous injection. PMID: 19234149

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  • 亚细胞定位：
    Cell membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Immunoglobulin superfamily
  • 数据库链接：

    HGNC: 6330

    OMIM: 604937

    KEGG: hsa:3803

    UniGene: Hs.743949