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  4. Recombinant Human Gonadotropin-releasing hormone receptor (GNRHR)

Recombinant Human Gonadotropin-releasing hormone receptor (GNRHR)

  • 货号：
    CSB-CF009637HU
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
  • Uniprot No.：
  • 别名：
    GNRHR; GRHR; Gonadotropin-releasing hormone receptor; GnRH receptor; GnRH-R
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-328
  • 氨基酸序列
    MANSASPEQNQNHCSAINNSIPLMQGNLPTLTLSGKIRVTVTFFLFLLSATFNASFLLKL QKWTQKKEKGKKLSRMKLLLKHLTLANLLETLIVMPLDGMWNITVQWYAGELLCKVLSYL KLFSMYAPAFMMVVISLDRSLAITRPLALKSNSKVGQSMVGLAWILSSVFAGPQLYIFRM IHLADSSGQTKVFSQCVTHCSFSQWWHQAFYNFFTFSCLFIIPLFIMLICNAKIIFTLTR VLHQDPHELQLNQSKNNIPRARLKTLKMTVAFATSFTVCWTPYYVLGIWYWFDPEMLNRL SDPVNHFFFLFAFLNPCFDPLIYGYFSL
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Receptor for gonadotropin releasing hormone (GnRH) that mediates the action of GnRH to stimulate the secretion of the gonadotropic hormones luteinizing hormone (LH) and follicle-stimulating hormone (FSH). This receptor mediates its action by association with G-proteins that activate a phosphatidylinositol-calcium second messenger system. Isoform 2 may act as an inhibitor of GnRH-R signaling.
  • 基因功能参考文献：
    1. Data, including identification of GnRH/GnRH-receptor system in both ovary and endometrium, suggest that the spectrum of action of GnRH/GnRH-receptor system extends outside its well-known hypothalamic functions. [REVIEW] PMID: 29544634
    2. c.364C>T in GNRHR is a complete loss-of-function mutation which caused idiopathic hypogonadotropic hypogonadism. PMID: 29777911
    3. GNRHR (and GNRH) are expressed in trophoblast cell populations and fallopian tube epithelium at tubal ectopic pregnancy sites. PMID: 26920257
    4. first description of a GNRHR gene mutation in three patients diagnosed with polycystic ovary syndrome. PMID: 28348023
    5. We showed that GNRHR and LHCGR were highly expressed in some wildtype aldosterone-producing adenoma samples, and that they positively correlated with GnRH-stimulated aldosterone production. PMID: 27196470
    6. Results show that biallelic gonadotropin releasing hormone receptor (GNRHR) mutations are not a frequent cause of age-related androgen decline in men. PMID: 26044071
    7. GnRH receptors on triple negative breast cancer cells can be used for targeted therapy of these cancers with GnRH agonist triptorelin PMID: 25293576
    8. study found a novel mutation in PROK2 in two male siblings presenting normosmic congenital hypogonadotropic hypogonadism, in whom a mutation in the GNRHR gene had been previously described, suggesting the possibility of a digenic inheritance PMID: 25531638
    9. A high prevalence of endometriosis, polymorphism in the LHCGR and GnRH1 and progonadoliberin-2 antibodies in serum was found among the patients with severe dysmotility after treatment with GnRH analogs. PMID: 25592315
    10. Mutations in GNRHR do not appear to be involved in the pathogenesis of constitutional delay of growth and puberty. PMID: 25016926
    11. Studies of the gonadotrope suggest that extracellular regulatory loops may play a central role in the regulation of gonadotropin gene expression by gonadotropin-releasing hormone (GnRH) receptor activation. PMID: 23994024
    12. Interaction between ER-associated Hsp40s and the Vps34 complex permits the selective degradation of ERAD-resistant membrane protein GNRHR via ERQC autophagy. PMID: 24685158
    13. A species specific motif participates in recognition of endoplasmic reticulum retention of the GnRHR by calnexin. PMID: 23891857
    14. The GnRH receptor is differentially expressed in pituitary gonadotrope cells vs. prostate cancer cells. PMID: 23380421
    15. We have generated human GNRHR1 knock-in mice and described their reproductive phenotype. PMID: 23632635
    16. Reversal of hyogonadotropic hypogonadism and late-onset hypogonadism are reported in an untreated patient with a R262Q mutation of GNRHR. PMID: 22788855
    17. Data show that GnRHR activation affected several cellular markers of locomotion, including actin organization and polymerization as well as active RhoA-GTP levels. PMID: 23176180
    18. SET protein interacts with intracellular domains of the gonadotropin-releasing hormone receptor and differentially regulates receptor signaling to cAMP and calcium in gonadotrope cells PMID: 23233674
    19. Review of the role of GNRHR in neoplasms and as a treatment target. [Review Article] PMID: 22778172
    20. Data suggest that mutations in GNRHR and TACR3 are the most common causative mutations in normosmic idiopathic hypogonadotropic hypogonadism in families in Turkey. PMID: 22766261
    21. GnRHR mutations can be classified into partial or complete loss of function mutations. Partially inactivating substitutions of the GnRHR frequently found in familial hypogonadotrophic hypogonadism are Q106R and R262Q. PMID: 23155690
    22. Normosmic Congenital hypogonadotropic hypogonadism (HH)patients with a R262Q mutation in GHRHR accompanied by other GNRHR mutation may be prone to reversal of HH. PMID: 22724017
    23. unidentified genetic and/or environmental factors may combine with singly mutated GNRHR alleles to produce reproductive phenotypes PMID: 22745237
    24. A potential role of GnRHR gene polymorphisms in the development of breast cancer. PMID: 22710726
    25. Molecular deficiencies of the two novel GNRHR1 mutations lead to the CHH phenotype when present as a compound heterozygote. PMID: 22679506
    26. molecular mechanisms involved in GnRH/GnRHR signaling at the maternal-fetal interface. {Review] PMID: 22024993
    27. Hypogonadotropic hypogonadism due to being homozygous for the G416A transition in the GNRHR gene. The parents were heterozygous mutation carriers. PMID: 21717411
    28. the TM4/ECL2 junction of GNRHR is crucial for peptide ligand binding and, consequently, for ligand-induced receptor conformational selection PMID: 21832286
    29. Thr104Ile and Tyr108Cys gonadotropin-releasing hormone receptors are misfolded structures whose function is rescuable by genetic and/or pharmacological strategies PMID: 21277937
    30. Positioning of the long extracellular loop within the seven-alpha-helical bundle regulates GnRH receptor stability, proper trafficking, and function. PMID: 21527534
    31. P-cadherin cooperates with insulin-like growth factor-1 receptor to promote metastatic signaling of gonadotropin-releasing hormone in ovarian cancer via p120 catenin. PMID: 21317933
    32. The findings suggest novel pathophysiological links between the GNRHR locus and thyroid function and insulin secretion in polycystic ovary syndrome patients. PMID: 21274726
    33. Data suggest that a subset of patients with primary aldosteronism has aberrant LHR and GNRHR expression, which could modulate aldosterone secretion. PMID: 21330483
    34. we discuss the composition and role of membrane rafts in cell signaling and examine evidence that the mammalian type I GnRHR is constitutively and exclusively localized to these membrane microdomains in various experimental model--REVIEW PMID: 20836995
    35. LH-RH receptor expression persisted despite prolonged exposure to LH-RH agonists in prostate cancer. PMID: 20670943
    36. GnRHa may be an effective stimulator of local peritoneal fibrinolytic activity, as it decreases PAI-1 secretion in peritoneal Met5A cells by a mechanism linked to GnRHR. PMID: 20236028
    37. Study conclude that the mammalian GnRH-RI is an intracellular GPCR that is expressed on the nuclear membrane. PMID: 20628612
    38. analysis of Pulsatile and sustained gonadotropin-releasing hormone (GnRH) receptor signaling PMID: 20507982
    39. Data show that among those GnRH receptor monoclonal antibodies, GHR-103, GHR-106 and GHR-114 exhibit high affinity and specificity to GnRH receptor as judged by the whole cell binding. PMID: 20182875
    40. Site-directed mutagenesis of the C-terminal domain of extracellular loop 2 of the human GnRH receptor showed that a minimum of two mutations is needed in this region for agonist activity of antagonist 135-18 PMID: 11981042
    41. the E(90)K mutation impairs hGnRHR-effector coupling; sequence modifications that enhance surface expression of the receptor restore function PMID: 11994356
    42. Novel homozygous splice acceptor site GnRH receptor (GnRHR) mutation: human GnRHR "knockout". amenorrhea and absent thelarche and pubarche PMID: 12050282
    43. conserved physical linkage in medaka and human genomes PMID: 12054603
    44. our results strongly indicate a role of the C/EBP and GATA motifs in regulating GnRHR gene transcription in human granulosa-luteal cells PMID: 12089350
    45. Locally expressed LHRH receptors mediate the oncostatic and antimetastatic activity of LHRH agonists on melanoma cells. PMID: 12161512
    46. results clearly indicate a role of octamer transcription factor-1 in the transcriptional repression of the human gonadotropin-releasing hormone receptor gene PMID: 12446597
    47. A missense mutation in this gene is found in a case of complete hypogonadotropic hypogonadism. PMID: 12568864
    48. The dominant-negative effect of the naturally occurring receptor mutants for the WT hGnRHR, which has intrinsic low maturation efficiency suggesting that this effect and the diminished plasma membrane expression is a recent evolutionary event. PMID: 12843188
    49. direct role for the GnRHR in mediating antiproliferative events in two cell systems, neither of which was derived from extrapituitary reproductive tumors. PMID: 14551223
    50. Neurons express GnRH receptor and responded to GnRH with time- and dose-dependent increases in GnRH gene expression and protein release. PMID: 14565958

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  • 相关疾病：
    Hypogonadotropic hypogonadism 7 with or without anosmia (HH7)
  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 1 family
  • 组织特异性：
    Pituitary, ovary, testis, breast and prostate but not in liver and spleen.
  • 数据库链接：

    HGNC: 4421

    OMIM: 138850

    KEGG: hsa:2798

    STRING: 9606.ENSP00000226413

    UniGene: Hs.407587