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  4. Recombinant Human Cadherin-3 (CDH3)

Recombinant Human Cadherin-3 (CDH3)

  • 货号：
    CSB-CF005052HU
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
    CDH3
  • Uniprot No.：
  • 别名：
    CDH3; CDHP; Cadherin-3; Placental cadherin; P-cadherin
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    108-829
  • 氨基酸序列
    DWVVAPISVPENGKGPFPQRLNQLKSNKDRDTKIFYSITGPGADSPPEGVFAVEKETGWLLLNKPLDREEIAKYELFGHAVSENGASVEDPMNISIIVTDQNDHKPKFTQDTFRGSVLEGVLPGTSVMQVTATDEDDAIYTYNGVVAYSIHSQEPKDPHDLMFTIHRSTGTISVISSGLDREKVPEYTLTIQATDMDGDGSTTTAVAVVEILDANDNAPMFDPQKYEAHVPENAVGHEVQRLTVTDLDAPNSPAWRATYLIMGGDDGDHFTITTHPESNQGILTTRKGLDFEAKNQHTLYVEVTNEAPFVLKLPTSTATIVVHVEDVNEAPVFVPPSKVVEVQEGIPTGEPVCVYTAEDPDKENQKISYRILRDPAGWLAMDPDSGQVTAVGTLDREDEQFVRNNIYEVMVLAMDNGSPPTTGTGTLLLTLIDVNDHGPVPEPRQITICNQSPVRQVLNITDKDLSPHTSPFQAQLTDDSDIYWTAEVNEEGDTVVLSLKKFLKQDTYDVHLSLSDHGNKEQLTVIRATVCDCHGHVETCPGPWKGGFILPVLGAVLALLFLLLVLLLLVRKKRKIKEPLLLPEDDTRDNVFYYGEEGGGEEDQDYDITQLHRGLEARPEVVLRNDVAPTIIPTPMYRPRPANPDEIGNFIIENLKAANTDPTAPPYDTLLVFDYEGSGSDAASLSSLTSSASDQDQDYDYLNEWGSRFKKLADMYGGGEDD
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
  • 基因功能参考文献：
    1. the evaluation of P-cadherin expression in lymph node metastases is an important predictor of disease outcome in breast cancer axillary lymph node metastases PMID: 28084338
    2. P-cadherin (CDH3) is highly dominant in both mouse and human retinal pigment epithelium in situ. The degree of dominance of P-cadherin is surprisingly large, with mouse Cdh3 and human CDH3 accounting for 82-85% and 92-93% of the total of the three cadherin mRNAs, respectively. PMID: 29338041
    3. Ophthalmologists should consider the diagnosis of CDH3-related retinopathy in individuals with such clinical features whether or not there is frank hypotrichosis. PMID: 26885695
    4. Adhesive dimerization of human P-cadherin catalyzed by a chaperone-like mechanism has been described. PMID: 27545624
    5. Results strongly advocated a pathogenic potential of the novel variants of CDH3 for the HJMD phenotypes. PMID: 27456782
    6. CDH3-related disease is characterized by a childhood-onset, progressive chorioretinal atrophy confined to the posterior pole. PMID: 27386845
    7. This study aimed to demonstrate the usefulness of mRNA expression levels of cadherin 3 (CDH3) in brush cytology specimens combined with cytology for the diagnosis of malignant biliary stricture PMID: 27399126
    8. CDH3 was negatively regulated at the genomic, transcriptional, and epigenetic level in PCa. PMID: 26771841
    9. The P-cadherin structure and packing arrangement provide new and valuable information towards the complete structural characterization of the cadherin dimerization pathway. PMID: 25849494
    10. In patients with breast infiltrating ductal carcinoma, P-cadherin was expressed in 40.5% of cases; P-cadherin expression had a negative relationship with the overall survival PMID: 26299056
    11. results establish a link between aberrant P-cadherin expression and hypoxic, glycolytic and acid-resistant breast cancer cells, suggesting a possible role for this marker in cancer cell metabolism PMID: 25269858
    12. Downregulation of P-cadherin expression appears to induce tumorigenicity in hepatocellular carcinoma. PMID: 25337260
    13. P-cadherin is able to potentiate ligand-dependent signaling of insulin-like growth factor 1 receptor in malignant keratinocytes and epidermal growth factor receptor in dysplastic cells. PMID: 25322858
    14. These findings indicate that HOXA9 contributes to poor outcomes in Epithelial ovarian cancer in part by promoting intraperitoneal dissemination via its induction of P-cadherin. PMID: 25023983
    15. The X-dimer plays a key role in the specific cell-cell adhesion mediated by human P-cadherin. PMID: 24559158
    16. Increased expression of CDH3 is associated with colorectal cancer. PMID: 23682078
    17. Loss of P-cadherin expression is associated with oral squamous cell carcinoma. PMID: 23740836
    18. P-cadherin and vimentin could be adjunctive to the commonly used immunohistochemical surrogates for basal-like breast cancer identification PMID: 24139214
    19. High CDH3 expression is associated with aggressive breast tumour behaviour. PMID: 23405208
    20. P-cadherin-mediated signaling is a melanocyte subtype-specific topobiological regulator of normal human pigmentation, possibly via GSK3beta-mediated canonical Wnt signaling. PMID: 23334344
    21. LA carcinomas and carcinomas negative for basal markers were more often negative for epithelial cell adhesion molecule (Ep-CAM) and P-cadherin PMID: 22531681
    22. Hypotrichosis associated with juvenile macular dystrophy is caused by mutations in CDH3, which encodes P-cadherin, a member of the classic cadherin family. PMID: 23143461
    23. P-cadherin regulates human hair growth and cycling via canonical Wnt signaling and transforming growth factor-beta2. PMID: 22696062
    24. Compared with conventional carcinomas, serrated adenocarcinomas showed no significant difference in P-cadherin staining. PMID: 22209340
    25. A novel nonsense CDH3 mutation in hypotrichosis with juvenile macular dystrophy PMID: 22348569
    26. High P-cadherin promotes liver metastasis and is associated with colon cancer. PMID: 21703417
    27. P-cadherin cooperates with insulin-like growth factor-1 receptor to promote metastatic signaling of gonadotropin-releasing hormone in ovarian cancer via p120 catenin. PMID: 21317933
    28. a novel splice site mutation (c.IVS10-1 G --> A) in intron 10, which leads to skipping of exon 11 in CDH3 gene in family with hypotrichosis with juvenile macular dystrophy PMID: 20140736
    29. P-cadherin positivity is associated with high-grade breast cancer subtypes and well-established markers of poor prognosis. PMID: 20852590
    30. Stable knockdown of P-cadherin in RT-112 cells diminished invasion and migration, and promoted intercellular adhesion PMID: 20473917
    31. Data conclude that P-cadherin counteracts the expression and function of myosin II-B, resulting in the suppression of the invasive and migratory behaviour of BLM melanoma cells. PMID: 20860798
    32. P-cadherin and CD24 are expressed in carcinomas of the biliary tract with high frequency and at an early stage of carcinogenesis. PMID: 20621328
    33. Overexpression of CDH3 is associated with basal-like phenotype in breast cancer. PMID: 19882246
    34. C/EBPbeta is able to up-regulate CDH3 promoter activity in breast cancer cells; the expression of P-cadherin linked with a worse prognosis of breast cancer patients PMID: 20385540
    35. 2 splice site mutations (one novel and one recurrent mutation) were in the CDH3 gene leading to hypotrichosis with juvenile macular dystrophy. PMID: 20203473
    36. P-cadherin gene expression proved to be a significant independent prognostic factor for both cancer-specific and recurrence-free survival in bladder cancer PMID: 20204300
    37. high levels of 80 kDa sP-cadherin in human milk. PMID: 11891861
    38. results point to the close relationship between the de novo expression of P-cadherin and the disruption of the cadherin/catenins complex with the squamoid phenotype of mucoepidermoid carcinoma of the thyroid (MECT) PMID: 12021924
    39. may play a central role in the development of endometriosis by mediating endometrial-peritoneal cell interactions in a homophilic manner PMID: 12112590
    40. Regulated expression of P-cadherin/beta-catenin complexes in ovarian tumor cells may represent a key step in disease progression PMID: 12800191
    41. Inappropriate PCAD expression in mouse mammary epithelium is compatible with normal mammary gland function. PMID: 12919105
    42. An absent P-cadherin expression could constitute a hallmark of aggressive biological behaviour in oral squamous cell carcinoma. PMID: 15375751
    43. In summary, we have ascertained a third gene associated with ectrodactyly and have demonstrated a hitherto unrecognised role of CDH3 in shaping the human hand PMID: 15805154
    44. A short truncated 50 kDa form of the N-terminal part of P-cadherin expresses in melanoma cell lines compared to melanocytes and keratinocytes. PMID: 15817166
    45. P-cadherin may have a role in progression of oral squamous cell carcinoma PMID: 15967043
    46. P-cadherin expression was strongly associated with tumor aggressiveness, being a good indicator of clinical outcome, and the aberrant expression of P-cadherin in breast cancer might be regulated by gene promoter hypomethylation. PMID: 16115928
    47. Novel heterozygous CDH3 mutations in hypotrichosis with juvenile macular dystrophy in two nonconsaguineous families. PMID: 17342797
    48. P-cadherin may be regarded as an additional immunohistochemical marker of basal-like breast carcinomas. PMID: 18074863
    49. P-cadherin is a newly defined transcriptional target gene of p63, with a crucial role in hair follicle morphogenesis as well as the apical ectodermal ridge during limb bud outgrowth in humans. PMID: 18199584
    50. Tunisian IBCs are characterized by frequent basal and ERBB2 phenotypes. Surprisingly, luminal inflammatory breast cancer also express the basal marker P-cadherin. PMID: 18230143

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  • 相关疾病：
    Hypotrichosis congenital with juvenile macular dystrophy (HJMD); Ectodermal dysplasia, ectrodactyly, and macular dystrophy syndrome (EEMS)
  • 亚细胞定位：
    Cell membrane; Single-pass type I membrane protein.
  • 组织特异性：
    Expressed in some normal epithelial tissues and in some carcinoma cell lines.
  • 数据库链接：

    HGNC: 1762

    OMIM: 114021

    KEGG: hsa:1001

    STRING: 9606.ENSP00000264012

    UniGene: Hs.191842