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  4. Recombinant Human Brain protein I3 (BRI3)

Recombinant Human Brain protein I3 (BRI3)

  • 货号：
    CSB-CF002811HU
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
    BRI3
  • Uniprot No.：
  • 别名：
    BRI3; Brain protein I3; pRGR2
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-125
  • 氨基酸序列
    MDHKPLLQERPPAYNLEAGQGDYACGPHGYGAIPAAPPPPPYPYLVTGIPTHHPRVYNIH SRTVTRYPANSIVVVGGCPVCRVGVLEDCFTFLGIFLAIILFPFGFICCFALRKRRCPNC GATFA
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Participates in tumor necrosis factor-alpha (TNF)-induced cell death. May be a target of Wnt/beta-catenin signaling in the liver.
  • 基因功能参考文献：
    1. In the context of hepatocellular carcinoma cells, BRI3 is a target of WNT signaling. PMID: 20538055
    2. An X-ray data set was collected to 1.6 A resolution using synchrotron radiation, of a ligandin recombinant fusion protein. PMID: 16508092
    3. Possible roles of BRI3 in the process of neuronal differentiation. PMID: 18452648
    4. BRI3 inhibits the various processing of amyloid protein precursor by blocking the access of alpha- and beta-secretases. PMID: 19366692
    5. BRI3 RNA is expressed less in stage 3 colon cancer in comparison to stage 2 colon cancer, and it is among 8 genes which can be used as a gene signature to differentiate colon cancer stages. PMID: 17390049

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  • 亚细胞定位：
    Lysosome membrane; Multi-pass membrane protein.; [Isoform 1]: Cytoplasm, perinuclear region.; [Isoform 2]: Cytoplasm. Nucleus.
  • 蛋白家族：
    BRI3 family
  • 数据库链接：

    HGNC: 1109

    OMIM: 615628

    KEGG: hsa:25798

    STRING: 9606.ENSP00000297290

    UniGene: Hs.567438