Recombinant Human B2 bradykinin receptor (BDKRB2)

1. Study results indicated that the bradykinin B2 receptor-mediated pathway is involved in the cPLA2-related inflammatory response from the PKC pathway in traumatic brain injury. PMID: 29894755
2. The most characteristic signaling pathways for B2R and D2R, dependent on intracellular Ca(2+) and cAMP concentration, respectively, were analyzed in cells presenting similar endogenous expression of B2R and D2R.The evidence of B2R-D2R dimerization may open new perspectives in the modulation of diverse cellular functions which depend on their activation. PMID: 28757212
3. These results indicate that KOR can form a heterodimer with B2R and this leads to increased protein kinase A activity by the CREB signaling pathway, leading to a significant increase in cell proliferation. PMID: 28069442
4. Study demonstrated the ability of long-chain polyunsaturated fatty acids to act as agonist to the B2R at nanomolar concentrations and to induce receptor conformational changes. PMID: 23826374
5. Data suggest that N-myc (and STAT) interactor (NMI) could improve its downstream target bradykinin B2 receptor (BDKRB2) expression to induce extracellular signal-regulated kinases (ERK) 1/2 activation, and thereby further evoke malignant progression of hepatocellular carcinoma (HCC). PMID: 28077802
6. BDKRB2 +9/-9 bp polymorphisms affected the gene expression and nitric oxide production, which were associated with radiographic severity of osteoarthritis, suggesting that the BDKRB2 +9/ -9 bp polymorphisms may act as a genetic modulator of osteoarthritis, and play an essential role in inflammatory process in osteoarthritis. PMID: 26764266
7. Review/Meta-analysis: suggest bradykinin B2 receptor -58C allele and -58CC genotype increase the risk of hypertension in Asians and African-Americans. Inversely, -58TT genotype decreases the risk of hypertension in Asians and African-Americans. PMID: 27007662
8. s found significant interactions among PRKCA, NOS3 and BDKRB2 genotypes associated with enalapril responses. PMID: 27696692
9. Bronchial B2R expression is constitutively elevated in allergic asthma and is further increased after allergen exposure together with NF-kB expression. PMID: 26588817
10. Report the presence of nuclear B2R in the utero-placental unit and reduced abundance of nuclear B2R in extravillous trophoblast in preeclampsia. PMID: 26955769
11. Data provide evidence that the BDKRB2 +9/-9 polymorphisms influence pro-inflammatory cytokine levels in knee osteoarthritis by altering TLR-2 expression. PMID: 26982743
12. These results suggest that the response to long-term exercise training could be modulated by the BDKRB2 gene -9/+9 polymorphism in male athletes. In well-trained swimmers, BDKRB2 gene variation was not found to be an independent determinant of swimming performance. PMID: 26907838
13. Significant association between the -58T/C polymorphism and the increased risk of Hypertension was found in Northern Han Chinese population. PMID: 26362411
14. Bradykinin inhibits oxidative stress-induced senescence of endothelial progenitor cells through the B2R/AKT/RB and B2R/EGFR/RB signal pathways. PMID: 26360782
15. Bradykinin receptor B2 (B2R) genetic variation may affect thirst because of effects bradykinin activity. PMID: 25641172
16. These results indicate that B2R couples with P2Y2R and that these G-protein-coupled receptors act together to fine-tune cellular responsiveness. PMID: 25713410
17. The nasal mucosa specimens from chronic rhinosinusitis patients expressed relatively higher B2R and slightly higher kininogen (KNG)/BK and B1R. PMID: 25970620
18. A cross-talk was found between bradykinin B2 receptor and cytokines in retinal pigment epithelium. PMID: 26235941
19. no association between the -9/+9 polymorphism and elite athletic status PMID: 25078958
20. Genetic variation was observed in obese patients with hypertension, obese patients' total cholesterol levels varied by genotype, and waist circumference and blood pressure were elevated in the non-obese having a C/C genotype compared to T/C and T/T. PMID: 25529519
21. Bradykinin receptor B2-VNTR length polymorphism was not associated with angina pectoris and myocardial infarction in Russian men. PMID: 25842860
22. Bradykinin increases IL-6 production via B2R and the ERK pathway, thereby contributing to the invasion and migration of colorectal cancer cells. PMID: 25109623
23. B2 receptor-mediated relaxation reduced in myometrial vessels in pre-eclampsia PMID: 24304135
24. We propose that heterodimerization of bradykinin B2 receptor with lamin C is essential to nuclear localization of bradykinin B2 receptor and plays an important role in cell signaling and function. PMID: 24211782
25. Bradykinin activates multiple signal transduction pathways in human trabecular meshwork cells via B2-receptors that also mediate intraocular pressure reduction PMID: 24236827
26. These results suggest that reflex muscle vasodilation and ACE activity in response to exercise training are modulated by BDKRB gene +9/-9 polymorphism in healthy individuals. PMID: 23613132
27. Bradykinin induces ATP release from human subcutaneous fibroblasts via connexin and pannexin-1-containing hemichannels leading to [Ca2+]i mobilization through the cooperation of B2 and P2Y12 receptors PMID: 24047499
28. Bradykinin induced asthmatic fibroblast/myofibroblast activities via bradykinin B2 receptor and different MAPK pathways. PMID: 23588115
29. Our data suggest that the B -9 allele and reduced ACE activity are associated with both ACE-AE and ACE-cough. PMID: 23730990
30. Dominant negative (GDP-locked)-Rab5 and -Rab11 reproduced the effects of inhibitors of tubulin and actin, respectively, on the cycling of bradykinin B receptor. PMID: 23454239
31. These studies have provided evidence of a functional endogenously expressed B-receptor system in the ciliary muscle that appears to be involved in modulating intraocular pressure. PMID: 23805043
32. there is a higher frequency of the D allele (high plasma ACE activity) and +9 allele (lower B2R expression) in transplant patients compared with control individuals PMID: 23362199
33. Triceps brachii morphological response to targeted strength training--hypertrophy--is related to bradykinin type (BK)2 receptor polymorphisms. PMID: 23127247
34. Our findings suggest that both eNOS and bradykinin B2 receptor genotypes may affect the antihypertensive responses to enalapril. PMID: 22706620
35. In coronary artery disease patients, bradykinin-B2-receptor downregulation on endothelial repair-promoting circulating mononuclear cells substantially impairs bradykinin-dependent endothelial repair. PMID: 23275384
36. results suggest that the co-existence of ACE (D/D), BDKRB2 (+9/-9) or LEP (G/A) genotypes in female athletes might be correlated with a superior level of physical performance PMID: 23176367
37. Suggest that the BDKRB2 +9/-9 polymorphism may act as a genetic modulator of glucose homeostasis and increase susceptibility to diabetes. PMID: 23243416
38. Bradykinin up-regulates B(2) receptor expression (P<0.05) and stimulate IL-8 release (P<0.001) in BEAS-2B cells. PMID: 22935637
39. Kinin-B2 receptor activity determines the differentiation fate of neural stem cells. PMID: 23132855
40. The BDKRB2-58T/C gene polymorphism is associated with increased EH risk. The results of this study suggest that carriers of the -58C allele are susceptible to EH. PMID: 22900090
41. Bradykinin enhances cell migration in human prostate cancer cells through B2 receptor/PKCdelta/c-Src dependent signaling pathway. PMID: 22653778
42. The +9/-9 bp polymorphisms of BDKRB2 gene may be used as a genetic marker for the susceptibility and severity of OA. PMID: 23093849
43. expression showed a growing trend with grade of endometrial cancer, reaching the peak in grade 2, whereas grade 3 was characterized by a decrease in transcriptional activity PMID: 22706224
44. Maximakinin is an agonist of the human and rabbit B(2)R with a 8-12 fold lesser potency. PMID: 22108573
45. While -58C>T polymorphism did not reveal any association with essential hypertension, +/-9 bp polymorphism showed a significant association with high risk for heterozygotes (+9/-9) when tested against the pooled frequencies of homozygotes. PMID: 22468762
46. Capillary electrophoresis is a rapid, accurate and sensitive method for genotyping the 9-bp exon 1 insertion/deletion polymorphism in BDKRB2. PMID: 22304584
47. Tested the influence of the interaction between the BDKRB2 -9/+9 and the GNB3 C825T (rs5443) genotypes in relation to endurance performance. There was no interaction between BDKRB2 -9/+9 and GNB3 C825T polymorphisms in relation to endurance. PMID: 21210858
48. Results demonstrate that helix 8 of the B(2)R plays a crucial role not only in efficient trafficking to the plasma membrane or the activation of G proteins but also for the interaction of the B(2)R with GRK2/3 and beta-arrestins. PMID: 22016392
49. Aging cardiac endothelial cells gradually lose their capacity to express BK-2Rs. PMID: 21986469
50. High molecular weight kininogen activates B2 receptor signaling pathway in human vascular endothelial cells. PMID: 21586566

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HGNC: 1030

OMIM: 113503

KEGG: hsa:624

STRING: 9606.ENSP00000307713

UniGene: Hs.654542