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  4. Recombinant Human Acyl-CoA desaturase (SCD)

Recombinant Human Acyl-CoA desaturase (SCD)

  • 中文名称：
    人SCD重组蛋白
  • 货号：
    CSB-CF020802HU
  • 规格：
    ￥9720
  • 图片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

产品详情

  • 纯度：
    Greater than 85% as determined by SDS-PAGE.
  • 基因名：
  • Uniprot No.：
  • 别名：
    SCD; FADS5; SCD1; SCDOS; Stearoyl-CoA desaturase; hSCD1; Acyl-CoA desaturase; Delta(9-desaturase; Delta-9 desaturase; Fatty acid desaturase
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length
  • 来源：
    in vitro E.coli expression system
  • 分子量：
    44.3 kDa
  • 表达区域：
    1-359aa
  • 氨基酸序列
    MPAHLLQDDISSSYTTTTTITAPPSRVLQNGGDKLETMPLYLEDDIRPDIKDDIYDPTYKDKEGPSPKVEYVWRNIILMSLLHLGALYGITLIPTCKFYTWLWGVFYYFVSALGITAGAHRLWSHRSYKARLPLRLFLIIANTMAFQNDVYEWARDHRAHHKFSETHADPHNSRRGFFFSHVGWLLVRKHPAVKEKGSTLDLSDLEAEKLVMFQRRYYKPGLLMMCFILPTLVPWYFWGETFQNSVFVATFLRYAVVLNATWLVNSAAHLFGYRPYDKNISPRENILVSLGAVGEGFHNYHHSFPYDYSASEYRWHINFTTFFIDCMAALGLAYDRKKVSKAAILARIKRTGDGNYKSG
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Stearoyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates. Catalyzes the insertion of a cis double bond at the delta-9 position into fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA. Gives rise to a mixture of 16:1 and 18:1 unsaturated fatty acids. Plays an important role in lipid biosynthesis. Plays an important role in regulating the expression of genes that are involved in lipogenesis and in regulating mitochondrial fatty acid oxidation. Plays an important role in body energy homeostasis. Contributes to the biosynthesis of membrane phospholipids, cholesterol esters and triglycerides.
  • 基因功能参考文献：
    1. Study results suggest that stearoyl-coenzyme A desaturase 1 activity is required for cumulus cell lipid storage and steroidogenesis. PMID: 28345489
    2. study has provided evidence supporting the potential role of SCD1 as a biomarker for human bladder cancer prognosis. PMID: 29396722
    3. SCD1 overexpression was found in Hepatocellular Carcinomas , which was associated with shorter disease-free survival. PMID: 28647567
    4. Experimental models in mice and human epithelial cells suggest that inhibition of stearoyl-coenzyme A desaturase activity leads to airway hyper-responsiveness and reduced antiviral defense. PMID: 28397284
    5. alterations in leptin and SCD-1 in HCU patients PMID: 28801090
    6. CD36, also known as FA translocase (FAT), that functions as a transmembrane protein and mediates the uptake of FAs, is observed to be highly expressed in breast cancer tissues. Furthermore, the anti-proliferation effect caused by the SCD1 inhibitor can not be reversed by exogenous oleic acid supplementation in CD36 knockdown breast cancer cells PMID: 28765876
    7. Our findings suggested that SCD1 plays a key role in the pathophysiology of leptin resistance in neuronal cells associated with obesity. PMID: 28768997
    8. high expression of SCD1 is more frequently observed in late stage lung adenocarcinoma patients and presents poor prognosis PMID: 27223066
    9. Our results suggest that relatively common genetic variants in stearoyl CoA desaturase and SREBF1 attenuated the positive associations between intake of a traditional diet rich in n-3 polyunsaturated fatty acids and increases in fasting cholesterol and HbA1c levels, as well as the waist-to-hip ratio among Yup'ik participants. PMID: 27467133
    10. Results provide evidence that SCD is a regulator of breast stemness. PMID: 27306423
    11. these data demonstrate for the first time the involvement of SCD1 in the regulation of the Hippo pathway in lung cancer, and point to fatty acids metabolism as a key regulator of lung cancer stem cells. PMID: 28368399
    12. High SCD1 expression is associated with resistance to cisplatin in lung cancer. PMID: 28797843
    13. Results provide evidence that the hepatic BSCL2 deficiency induces the increase and expansion of lipid droplets potentially via increased SCD1 activity. PMID: 27838812
    14. high SCD1 expression is an independent prognostic factor for OS in patients with ccRCC. Our data suggest that the expression of SCD1 might guide the clinical decisions for patients with ccRCC. PMID: 27861513
    15. A relevant link between one-night sleep deprivation , hepatic SCD1 expression and de-novo fatty acid synthesis via epigenetically driven regulatory mechanisms was found. PMID: 27562731
    16. stearoyl-coenzyme A desaturase 1 has a role in clear cell renal cell carcinoma PMID: 26224474
    17. Chronic exposure to chewing tobacco induces carcinogenesis in non-malignant oral epithelial cells and SCD plays an essential role in this process. PMID: 26391970
    18. This study illustrates for the first time that, in contrast to hepatic and adipose tissue, estrogen induces SCD-1 expression and activity in breast carcinoma cells. These results support SCD-1 as a therapeutic target in estrogen-sensitive breast cancer. PMID: 26022099
    19. The data indicate a direct inhibitory interaction of polyunsaturated fatty acids with LXRalpha, a consequent reduction of SREBP-1 and of its binding to SCD1 promoter. PMID: 25264165
    20. Both siRNA-mediated and pharmacological inhibition of SCD1 impaired tumor cells migration. PMID: 25880005
    21. SCD1 is found upregulated upon renal cell transformation indicating that its activity, while not impacting proliferation, represents a critical bottleneck for tumourigenesis PMID: 24769897
    22. SCD1 negatively regulates autophagy-induced cell death in human hepatocellular carcinoma through inactivation of the AMPK signaling pathway. PMID: 25528629
    23. An association with Graves ophthalmopathy was shown for SNP rs1393491 in SCD. PMID: 24780075
    24. Stearoyl-CoA desaturase is encoded by an SCD gene, which, depending on the species, may exist as different isoforms. (review) PMID: 24864084
    25. DNA methylation levels of the SCD1 promoter were associated with weight change and with adherence to a Mediterranean diet. PMID: 24827925
    26. These data further support the idea that SCD1 is associated with hepatitis C virus replication complex and that its products may contribute to the proper formation and maintenance of membranous web structures during virus replication. PMID: 25122791
    27. These results demonstrate that cardiometabolic risk factors are modulated by genetic variations in the SCD1 gene alone or in combination with n-3 polyunsaturated fatty acid supplementation. PMID: 24375980
    28. Genetic variation of the SCD1 gene may contribute to the risk of obesity, interacting with the type of dietary fat. PMID: 23934750
    29. The effect of fenretinide on stearoyl-CoA desaturase should be considered in its potential therapeutic role against cancer, type-2 diabetes, and retinal diseases. PMID: 24357007
    30. The results suggest that SCD1 is a critical target in lung cancer tumor-initiating cells. PMID: 24309934
    31. genetic association studies in population of men in Sweden: Data suggest that SNPs in SCD1 are associated with cancer death, especially among men with low intake of dietary polyunsaturated fatty acids. PMID: 24368438
    32. This minireview summarizes the role of skin SCD1 in regulating skin integrity and whole body energy homeostasis and offers a discussion of potential pathways that may connect these seemingly disparate phenotypes. PMID: 24356954
    33. SCD was strongly expressed in surgically resected hepatocellular carcinoma (HCC) (n = 64) and various human HCC cell lines PMID: 24135379
    34. Human breast cancer tissues contain abundant phosphatidylcholine(36ratio1) with high stearoyl-CoA desaturase-1 expression. PMID: 23613812
    35. Increased SCD1 expression supports clear cell renal cell carcinoma cell viability. PMID: 23633458
    36. Patients with primary breast cancers expressing high SCD1 levels had significantly shorter relapse-free survival and overall survival in multivariable analysis. PMID: 23208590
    37. Both SCD1 and HIF-2alpha are critical to promoting tumorigenesis by synergistically acting on maintaining cell survival, triggering cell migration, and enhancing the colony formation ability of ca PMID: 23331615
    38. In a large community-based prospective cohort study, the estimate of SCD-1 activity by SCD16c had the strongest association with incident diabetes. PMID: 22819528
    39. There are no associations between common variants of SCD1 or its inferred haplotypes and the investigated metabolic risk factors. PMID: 23139775
    40. In human bladder cancer cell lines expressing constitutively active FGFR3, knockdown of SCD1 by siRNA markedly attenuated cell-cycle progression, reduced proliferation, and induced apoptosis. PMID: 23019225
    41. findings show low SCD1 expression is linked to a decrease in proliferation rate of breast cancer cells; this was accompanied by an increase in GSK3 activity; nuclear translocation of beta-catenin was decreased and its transactivation capacity; this suggests a role of SCD1 in EMT and cancer progression PMID: 23013158
    42. Thyroid hormone negatively regulates human SCD-1 gene expression in without direct binding of the TH receptor to the SCD-1 gene promoter. PMID: 23221600
    43. The individual hepatic SCD1 activity is a determinant of liver fat accumulation under lipogenic dietary conditions. PMID: 23015656
    44. data indicate that SCD activity may control lung cancer cell metabolism, proliferation and survival by modulating the EGFR-->Akt/ERK signaling platforms PMID: 22946088
    45. study showed cystic fibrosis cells exhibit increased metabolism along metabolic pathways leading to n-7 and n-9 fatty acids compared with wild-type cells; changes are accompanied by increased expression of Delta5, Delta6 and Delta9 desaturases and elongases 5 and 6 PMID: 21544602
    46. The mRNA levels of LXRalpha and SREBP-1c, transcription factors that regulate SCD-1, were decreased by 10,12 conjugated linoleic acid in human adipocytes. PMID: 21775116
    47. data outline an effective strategy to establish an unambiguous link between fatty acid synthesis and cancer cell survival, and point toward SCD1 as a key target in this pathway PMID: 22457791
    48. SCD1 activity and genetic variation have an important role in modulating the relationship between fatty acids and inflammation in young adults PMID: 22209225
    49. Repression of SCD1 by alpha-linolenic acid favorably increased cholesterol efflux and decreased cholesterol accumulation in foam cells. PMID: 21658928
    50. [review] muscle. This review evaluates the role of SCD-1 as a homeostatic check-point between glucose and fatty acid metabolism in the development and progression of obesity. PMID: 21831035

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  • 亚细胞定位：
    Endoplasmic reticulum membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Fatty acid desaturase type 1 family
  • 组织特异性：
    Detected in fetal liver, lung and brain. Highly expressed in adult adipose tissue, and at lower levels in adult brain and lung.
  • 数据库链接：

    HGNC: 10571

    OMIM: 604031

    KEGG: hsa:6319

    STRING: 9606.ENSP00000359380

    UniGene: Hs.558396