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  4. Recombinant Dog Cyclic nucleotide-gated cation channel beta-3 (CNGB3)

Recombinant Dog Cyclic nucleotide-gated cation channel beta-3 (CNGB3)

  • 货号：
    CSB-CF850746DO
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
  • Uniprot No.：
  • 别名：
    CNGB3; Cyclic nucleotide-gated cation channel beta-3; Cone photoreceptor cGMP-gated channel subunit beta; Cyclic nucleotide-gated cation channel modulatory subunit; Cyclic nucleotide-gated channel beta-3; CNG channel beta-3
  • 种属：
    Canis familiaris (Dog) (Canis lupus familiaris)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-782
  • 氨基酸序列
    MFKSLTIKSNKVKPREENDENKQDPDPSNQPQQSTRQGENKSENKSLQTKMTPVTFEESH AKMQDKISEKNSLRDLTTNPNHQHPTESKGAMSEQKEMETGKEGLVSPKSKPLGVPVINE YADAQLHNLVRRMRQRTMLYKKKLAEGDISSPEASPQTAKPTAVPSTQESNAKLKEEHYY HILCFKFQKMPLTEYLKRFRLPGSIDSYTDRLYLLWLLLVTIAYNWNCWLIPLRLVFPYQ TPDNTHYWFITDITCDIIYLCDMLLIQPRLQFIKGGDIMVDSNELKRHYRSSTKFQLDVA SVMPFDVFYLFFGFNPVFRMNRILKYTSFFEFNHHLESIMDKAYIYRVIRTTGYLLYTLH INACIYYWASDYEGIGSTKWVYNGEGNKYLRCYYWAVRTLITIGGLPEPQTSFEIVFQLL NFFSGVFVFSSLIGQMQDVIGAATANQNNFRISMDHTISYMNTYSIPKNVQNRVRTWYEY TWDSQRMLDESDLLCTLPVTMQLALTVDVNLSIISKVELFKGCDTQMIYDMLLRLKSTVY LPGDFVCKKGEIGKEMYIIKQGEVQVLGGSDGAQVLVTLKAGAVFGEISLLAGRGGNRRT ANVIAHGFANLLTLDKKTLQEILVHYPDSEKLLMKKASVLLKKKAPATETTPPRKGLAFL FPPKQETPKIFKALLGGTGKAGLTRLLKLKREQTIQKTSENSEEGGGKRREYEDKEREPS EKILDSSECRANCIIAEEMPQSIRRAALPRGTTRQSLIISMAPSAEAGEEVLTIEVKEKA KQ
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cGMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors. Induced a flickering channel gating, weakened the outward rectification in the presence of extracellular calcium, increased sensitivity for L-cis diltiazem and enhanced the cAMP efficacy of the channel when coexpressed with CNGA3. Essential for the generation of light-evoked electrical responses in the red-, green- and blue sensitive cones.
  • 基因功能参考文献：
    1. Missense mutation at position 262 in the canine CNGB3 (D262N) subunit results in loss of cone function (daylight blindness), suggesting an important role for this aspartic acid residue in channel biogenesis. PMID: 24586388
    2. Day blindness shows genetic heterogeneity within the CNGB3 gene of the Alaskan Malamute population of Australia. PMID: 16879359
  • 相关疾病：
    Defects in CNGB3 are a cause of cone degeneration (cd). Cd is characterized by day-blindness and absence of retinal cone function. This autosomal recessive disorder occurs naturally in the Alaskan Malamute and German Shorthaired Pointer breeds.
  • 亚细胞定位：
    Membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Cyclic nucleotide-gated cation channel (TC 1.A.1.5) family, CNGB3 subfamily
  • 数据库链接：

    KEGG: cfa:403554

    STRING: 9615.ENSCAFP00000036190

    UniGene: Cfa.72