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  4. Recombinant Chicken CD166 antigen (ALCAM)

Recombinant Chicken CD166 antigen (ALCAM)

  • 货号：
    CSB-CF001562CH
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
  • Uniprot No.：
  • 别名：
    ALCAM; CD166 antigen; Activated leukocyte cell adhesion molecule; BEN glycoprotein; Protein DM-GRASP; Protein JC7; SC1 glycoprotein; CD antigen CD166
  • 种属：
    Gallus gallus (Chicken)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    34-588
  • 氨基酸序列
    LYTVNAVYGDTITMPCRLEVPDGLMFGKWKYEMPNGSPVFIAFRSSTKKNVQYDDVPDYKDRLSLSENYTLSIKNARISDEKRFVCMLVTEDDVSEEPTVVKVFKQPSQPEILHQADFLETEKLKMLGECVVRDSYPEGNVTWYKNGRVLQPVEEVVVINLRKVENRSTGLFTMTSSLQYMPTKEDANAKFTCIVTYHGPSGQKTIQSEPVVFDVHYPTEKVTIRVLSQSSTIKEGDNVTLKCSGNGNPPPQEFLFYIPGETEGIRSSDTYVMTDVRRNATGEYKCSLIDKSMMDATTITVHYLDLQLTPSGEVTKQIGEALPVSCTISSSRNATVFWIKDNTRMKTSPSFSSLQYQDAGNYICETTLQEVEGLKKRKTLKLIVEGKPQIKMTKKTNTNKMSKTIVCHVEGFPKPAVQWTVTGSGSLINKTEETKYVNGKFSSKIIIAPEENVTLTCIAENELERTVTSLNVSAISIPEYDEPEDRNDDNSEKVNDQAKLIVGIVVGLLLVALVAGVVYWLYVKKSKTASKHVDKDLGNIEENKKLEENNHKSET
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Cell adhesion molecule that mediates both heterotypic cell-cell contacts via its interaction with CD6, as well as homotypic cell-cell contacts. Promotes T-cell activation and proliferation via its interactions with CD6. Contributes to the formation and maturation of the immunological synapse via its interactions with CD6. Mediates homotypic interactions with cells that express ALCAM. Mediates attachment of dendritic cells onto endothelial cells via homotypic interaction. Inhibits endothelial cell migration and promotes endothelial tube formation via homotypic interactions. Required for normal organization of the lymph vessel network. Required for normal hematopoietic stem cell engraftment in the bone marrow. Plays a role in hematopoiesis; required for normal numbers of hematopoietic stem cells in bone marrow. Promotes in vitro osteoblast proliferation and differentiation. Promotes neurite extension, axon growth and axon guidance; axons grow preferentially on surfaces that contain ALCAM. Mediates outgrowth and pathfinding for retinal ganglion cell axons.
  • 基因功能参考文献：
    1. impact of the growth cone translation of ALCAM on axonal functions PMID: 22421359
    2. SC1 might play a potential role in both the structural formation of nephroblastomas, based on its adhesive activity, and normal renal development. PMID: 16328046
    3. ubiquitination and endocytosis of DM-GRASP in concert regulate its cell surface concentration, which is crucial for its function in axon navigation PMID: 18790729
  • 亚细胞定位：
    Cell membrane; Single-pass type I membrane protein. Cell projection, axon. Cell projection, dendrite.
  • 组织特异性：
    Detected in embryo. Detected in embryonic spinal cord and embryonic brain. Within the spinal cord it is localized to axons in the dorsal funiculus, midline floor plate cells, and motoneurons. Detected in embryonic epithelia and brain. After hatching, dete
  • 数据库链接：

    KEGG: gga:396092

    STRING: 9031.ENSGALP00000024723

    UniGene: Gga.2734