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  4. Recombinant Bovine Oxidized low-density lipoprotein receptor 1 (OLR1)

Recombinant Bovine Oxidized low-density lipoprotein receptor 1 (OLR1)

  • 货号：
    CSB-CF016331BO
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
  • Uniprot No.：
  • 别名：
    OLR1; LOX1; Oxidized low-density lipoprotein receptor 1; Ox-LDL receptor 1; Lectin-like oxidized LDL receptor 1; LOX-1; Lectin-like oxLDL receptor 1; bLOX-1; Lectin-type oxidized LDL receptor 1
  • 种属：
    Bos taurus (Bovine)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-270
  • 氨基酸序列
    MTVDDPKGMKDQLDQKPNGKTAKGFVSSWRWYPAAVTLGVLCLGLLVTVILLILQLSQVSDLIKKQQANITHQEDILEGQILAQRRSEKSAQESQKELKEMIETLAHKLDEKSKKLMELHRQNLNLQEVLKEAANYSGPCPQDWLWHEENCYQFSSGSFNWEKSQENCLSLDAHLLKINSTDELEFIQQMIAHSSFPFWMGLSMRKPNYSWLWEDGTPLTPHLFRIQGAVSRMYPSGTCAYIQRGTVFAENCILTAFSICQKKANLLRAQ
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. Also acts as a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram-positive bacteria.
  • 基因功能参考文献：
    1. Endothelial LOX-1 overexpression in an atherosclerosis-prone LDL receptor knockout mice impairs endothelial function, proving its importance in the development of atherosclerosis. PMID: 29096854
    2. bta-miR-370 has a negative regulatory effect on the OLR1 gene at both the gene and protein expression levels and has a role in lipid metabolism in bovine adipocytes PMID: 28294375
    3. Overexpression of LOX-1 leads to the attenuation of protective autophagy response in aortic endothelial cells. PMID: 25703423
    4. These results imply that the 3' UTR SNP of the OLR1 gene is a strong candidate marker for selection in cattle breeding programs. PMID: 23910552
    5. Our data indicate that blocking the LOX-1 receptor signal pathway might be a promising way to improve steroid hormone concentrations in metabolically highly active female mammals PMID: 24115745
    6. In the present study, we show that inhibition of LOX-1 leads to a rearrangement of ceramide from the basal membrane toward the Golgi apparatus PMID: 24710763
    7. The downregulation of eNOS by ox-low-density lipoprotein, as driven by LOX-1-mediated endoplasmic stress, is associated with the PI3K-Akt-eNOS signaling pathway. PMID: 24085225
    8. 3'-UTR SNP assoicated with milk composition traits and somatic cell score PMID: 22365237
    9. Disruption of lipid packing of cholesterol-rich membrane domains plays a key role in oxidized low-density lipoprotein (oxLDL)-induced changes in endothelial biomechanics. PMID: 20410437
    10. Oxidized low-density lipoprotein receptor (OLR1) single nucleotide polymorphism haplotype is associated with milk fat yield and fat percentage PMID: 16606746
    11. synergistic effects of cyclic tensile stretch load and ox-LDL on cell viability and proteoglycan synthesis in chondrocytes, which may be mediated through enhanced expression of LOX-1 PMID: 16795046
    12. Upregulates VEGF expression in articular cartilage, at least in part, through activation of PPAR-gamma. PMID: 16904074
    13. Mediation of electronegative low-density lipoprotein signaling by LOX-1: a possible mechanism of endothelial apoptosis. PMID: 19150883
    14. ox-LDL binding to LOX-1 induces stress-induced senescence of chondrocytes and suppression of telomerase activity. Oxidized LDL may play an important role in the pathogenesis of osteoarthritis by inducing chondrocyte senescence. PMID: 19790061

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  • 亚细胞定位：
    Cell membrane; Lipid-anchor. Cell membrane; Single-pass type II membrane protein. Membrane raft. Secreted.
  • 组织特异性：
    Highly expressed in endothelial cells, aortic intima and lung. Expressed at low level in other tissues.
  • 数据库链接：

    KEGG: bta:281368

    STRING: 9913.ENSBTAP00000005975

    UniGene: Bt.367