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  4. Recombinant Bovine Lysosomal-associated transmembrane protein 4B (LAPTM4B)

Recombinant Bovine Lysosomal-associated transmembrane protein 4B (LAPTM4B)

  • 货号：
    CSB-CF765155BO
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
    LAPTM4B
  • Uniprot No.：
  • 别名：
    LAPTM4B; Lysosomal-associated transmembrane protein 4B
  • 种属：
    Bos taurus (Bovine)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-226
  • 氨基酸序列
    MKMVAPWTRFYSNSCCLCCHVRTGTILLGVWYLILNAVVLLILLSALADPDHYHFSSSEL GGDFEFMDDANMCIAIAISVLMILICAMATYGAYKQRAAWIIPFFCYQIFDFALNTLVAV TVLVYPNSIQEYIRQLPPDFPYKDDIMSVNPTCLVLIILLFISIILAFKGYLISCVWNCY RYINGRNSSDVLVYVTSNDSTVLLPPYDDATVNSATKEPPPPYVSA
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Required for optimal lysosomal function. Blocks EGF-stimulated EGFR intraluminal sorting and degradation. Conversely by binding with the phosphatidylinositol 4,5-bisphosphate, regulates its PIP5K1C interaction, inhibits HGS ubiquitination and relieves LAPTM4B inhibition of EGFR degradation. Recruits SLC3A2 and SLC7A5 (the Leu transporter) to the lysosome, promoting entry of leucine and other essential amino acid (EAA) into the lysosome, stimulating activation of proton-transporting vacuolar (V)-ATPase protein pump (V-ATPase) and hence mTORC1 activation. Plays a role as negative regulator of TGFB1 production in regulatory T cells. Binds ceramide and facilitates its exit from late endosome in order to control cell death pathways.
  • 基因功能参考文献：
    1. This study reports for the first time that bovine LAPTM4B in granulosa cells is present in both unubiquinated and ubiquinated forms, and is differentially expressed in developing ovarian follicles PMID: 25881887
    2. LAPTM4B is differentially expressed at the mRNA and protein levels in different bovine tissues. The mRNA yields a 26.3 kDa protein that undergoes mono-ubiquitination resulting in a 31.5 kDa isoform. Immunohistochemical observations revealed that LAPTM4B expression was highly variable among tissues, and among similar and adjacent cell types. LAPTM4B may confer protection against the accumulation of metabolic byproducts. PMID: 25881887
  • 亚细胞定位：
    Endomembrane system; Multi-pass membrane protein. Late endosome membrane. Cell membrane. Cell projection. Lysosome membrane. Endosome membrane. Endosome, multivesicular body membrane. Endosome, multivesicular body lumen.
  • 蛋白家族：
    LAPTM4/LAPTM5 transporter family
  • 组织特异性：
    Strongly expressed in fetal ovary, testis, adrenal gland, liver and uterus, and weakly expressed in the spleen.
  • 数据库链接：

    KEGG: bta:404155

    STRING: 9913.ENSBTAP00000022559

    UniGene: Bt.1143