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  4. Recombinant Bovine Lutropin-choriogonadotropic hormone receptor (LHCGR)

Recombinant Bovine Lutropin-choriogonadotropic hormone receptor (LHCGR)

  • 货号：
    CSB-CF635675BO
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
  • Uniprot No.：
  • 别名：
    LHCGR; Lutropin-choriogonadotropic hormone receptor; LH/CG-R; Luteinizing hormone receptor; LSH-R
  • 种属：
    Bos taurus (Bovine)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    27-701
  • 氨基酸序列
    LRPAPCPEPCSCPPDGALRCPGPQAGLSRLSLTYLPIKVIPSQAFRGLNEVIKIEISQSD SLEKIEANAFDNLLNLSEILIQNTKNLVHIEAGAFTNLPRLKYLSICNTGIHKLPDVTKI FSSEFNFILEICDNLHITTIPRNAFQGMNNESITLKLYGNGFEEIQSHAFNGTTLISLEL KENARLEKMHNDAFRGATGPSILDISSTKLQALPTYGLESIQTLIATSSYSLKKLPSREK FTNLLDATLTYPSHCCAFRNLPTNEQNFSFSIFKNFSKQCESTARRPNNETLYSAIFAES ELSGWDYDYGFCLPKTLQCAPEPDAFNPCEDIMGYNFLRVLIWLINILAITGNVTVLFVL LTSRYKLTVPRFLMCNLSFADFCMGLYLLLIASVDAQTKGQYYNHAIDWQTGSGCSAAGF FTVFASELSVYTLTVITLERWHTITYAIQLDQKLRLKHAIPVMLGGWLFSTLIAVLPLVG VSNYMKVSICLPMDVESTLSQVYILTILILNVMAFIIICACYIKIYFAVQNPELMATNKD TKIAKKMAVLIFTDFTCMAPISFFAISAAFKVPLITVTNSKVLLVLFYPVNSCANPFLYA IFTKAFQRDFFLLLSKFGCCKYRAELYRRKDFSAYISNCKNGFTGSNKPSRSTFKLTTLQ CQYSAVLDKTCYKEC
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase.
  • 基因功能参考文献：
    1. large numbers of unknown LH-regulated granulosa cell genes are identified and their putative roles in ovarian function, are reported. PMID: 23716604
    2. Gene expression of granulosa cells reveals that 747 transcripts are potentially regulated by LH. PMID: 28840634
    3. The outcomes of the present study support a dynamic multi-facetted regulation of LHR during pre-translation. PMID: 26507944
    4. expression of LHR mRNA in bovine granulosa cells is established after follicle deviation, and the lower abundance of LRBP mRNA after the expected time of deviation may contribute to greater expression of LHR in the bovine dominant follicle PMID: 26446749
    5. These results suggested an acute regulation of INSL3 by luteinizing hormone (LH) because INSL3 concentrations increased immediately after endogenous and exogenous LH stimulation. PMID: 26318230
    6. INVESTIGATION OF STAT5A, FSHR AND LHR GENE POLYMORPHISMS IN TURKISH INDIGENOUS CATTLE BREEDS PMID: 26845856
    7. These findings strongly support the concept that IGF-1 upregulates LHR expression in granulosa cells and that IGF-1 is required for determining which follicle becomes dominant and acquires ovulatory capacity. PMID: 25626338
    8. LHCGR mRNA expression in granulosa cells was significantly higher in large antral follicles than in cysts, and not detected in granulosa cells of small and medium antral follicles. PMID: 25454493
    9. The luteinizing hormone receptor [LHR] splicing pattern is complex in bovine Leydig cells, and expression of full-length LHR and isoforms A and B changes when induced with LH. PMID: 22843048
    10. Significant correlations were found between sperm quality parameters and polymorphisms in the luteinizing hromoe receptor gene in Chinese Holstein bulls. PMID: 22327646
    11. The LHCGR gene is a potential marker for superovulation response and can be used to predict the most appropriate dose of FSH for superovulation in Chinese Holstein cows. PMID: 21667104
    12. Dominant follicles experience a reduction in FSH dependence (diminished expression of FSHR), but acquire increased LH dependence (enhanced expression of LHCGR) as they grow during the low FSH milieu of follicular waves. PMID: 16481595
    13. Three single nucleotide polymorphisms in LHCGR were significantly associated with variations in cattle fertility and production traits. PMID: 17121604
    14. Granulosa cells do not acquire functional LHR until follicle dominance occurs. PMID: 17154302
    15. Heterozygous heifers showed a higher pregnancy rate (67 and 66% for LHR and FSHR genes, respectively), but no significant effects were observed for the genes studied ( PMID: 18393228
    16. Differential expression of LHRH-receptor in bovine nasal tissue and its role in deslorelin delivery PMID: 18992782

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 1 family, FSH/LSH/TSH subfamily
  • 数据库链接：

    KEGG: bta:281900

    STRING: 9913.ENSBTAP00000022047

    UniGene: Bt.37