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  4. Recombinant Zaire ebolavirus Membrane-associated protein VP24 (VP24)

Recombinant Zaire ebolavirus Membrane-associated protein VP24 (VP24)

  • 中文名称：
    Recombinant Zaire ebolavirus Membrane-associated protein VP24(VP24),Yeast
  • 货号：
    CSB-YP312226ZAB
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Zaire ebolavirus Membrane-associated protein VP24(VP24),Yeast
  • 货号：
    CSB-EP312226ZAB
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Zaire ebolavirus Membrane-associated protein VP24(VP24),Yeast
  • 货号：
    CSB-EP312226ZAB-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Zaire ebolavirus Membrane-associated protein VP24(VP24),Yeast
  • 货号：
    CSB-BP312226ZAB
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Zaire ebolavirus Membrane-associated protein VP24(VP24),Yeast
  • 货号：
    CSB-MP312226ZAB
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    VP24
  • Uniprot No.：
  • 别名：
    VP24Membrane-associated protein VP24; Ebola VP24; eVP24
  • 种属：
    Zaire ebolavirus (strain Mayinga-76) (ZEBOV) (Zaire Ebola virus)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-251
  • 氨基酸序列
    MAKATGRYNL ISPKKDLEKG VVLSDLCNFL VSQTIQGWKV YWAGIEFDVT HKGMALLHRL KTNDFAPAWS MTRNLFPHLF QNPNSTIESP LWALRVILAA GIQDQLIDQS LIEPLAGALG LISDWLLTTN TNHFNMRTQR VKEQLSLKML SLIRSNILKF INKLDALHVV NYNGLLSSIE IGTQNHTIII TRTNMGFLVE LQEPDKSAMN RMKPGPAKFS LLHESTLKAF TQGSSTRMQS LILEFNSSLA I
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Prevents the establishment of cellular antiviral state by blocking the interferon-alpha/beta (IFN-alpha/beta) and IFN-gamma signaling pathways. Blocks the IFN-induced nuclear accumulation of host phosphorylated STAT1 by interacting with the STAT1-binding region of host importins. Alternatively interacts also directly with host STAT1 and may additionally inhibit its non-phosphorylated form. Plays a role in assembly of viral nucleocapsid and virion budding. May act as a minor matrix protein that plays a role in assembly of viral nucleocapsid and virion budding.
  • 基因功能参考文献：
    1. Novel molecular detail on the interaction of Reston virus VP24 and Ebola virus VP24 with human KPNA5 are provided PMID: 28812539
    2. VP24 protein plays a critical role in the evasion of the host immune response by interacting with human ATP1a1 protein. PMID: 25158218
    3. The VP24 induces host gene expression at 8 h but blocks it at 24 h. PMID: 25972536
    4. eVP24 recognizes a unique nonclassical nuclear localization signal binding site on KPNA5 that is necessary for efficient phosphoryated STAT1 nuclear transport. PMID: 25121748
    5. VP24 directly binds STAT1 and has a novel, pyramidal fold. PMID: 22383882
    6. The VP24 IFN antagonist function requires the ability of VP24 to interact with KPNalpha. PMID: 19889762
    7. These findings suggest that VP24 inhibits interaction of PY-STAT1 with karyopherins alpha1, alpha5, or alpha6 by binding within the PY-STAT1 binding region of the karyopherins. PMID: 17928350

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  • 亚细胞定位：
    Virion membrane; Peripheral membrane protein. Host cell membrane; Peripheral membrane protein; Cytoplasmic side. Host endomembrane system; Peripheral membrane protein.
  • 蛋白家族：
    Filoviridae membrane-associated protein VP24 family
  • 数据库链接：

    KEGG: vg:911828