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  4. Recombinant Xenopus laevis Protein Wnt-4 (wnt4)

Recombinant Xenopus laevis Protein Wnt-4 (wnt4)

  • 货号：
    CSB-YP026137XBE
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP026137XBE
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP026137XBE-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP026137XBE
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP026137XBE
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    wnt4; Protein Wnt-4; XWnt-4
  • 种属：
    Xenopus laevis (African clawed frog)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    23-351
  • 氨基酸序列
    SNWLYLAK LSSVGSISEE ETCEKLKGPI QRQVQMCKRN LEVMDSVRRG AQLAIEECQY QFRNRRWNCS TLDTLPVFGK VVTQGTREAA FVYAISSAGV AFAVTRACSS GDLEKCGCDR TVHGVSPQGF QWSGCSDNIL YGVAFSQSFV DVRERSKGGS SSRALMNLHN NEAGRKAILN NMRVECKCHG VSGSCEVKTC WKAMPTFRKV GNVLKEKFDG ATEVEQKKIG STKVLVPKNS QFKPHTDEDL VYLDSSPDFC DHDLKNGVLG TTGRQCNKTS KAIDGCELMC CGRGFHTEEV EIVERCSCKF HWCCFVKCKQ CHKVVEMHTC R
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Ligand for members of the frizzled family of seven transmembrane receptors. Plays an important role in embryonic kidney development. Acts downstream of Notch signaling during pronephric kidney development. During early pronephros development, patterns the proximal pronephric anlagen to promote glomus and nephrostome formation. Also required later in pronephros development for tubulogenesis.
  • 基因功能参考文献：
    1. identified Wnt4 as the ligand that is expressed in the mesoderm of the ventral blood island and is essential for the expression of hematopoietic and erythroid marker genes PMID: 20805504
    2. XWntless and the Retromer complex are required for the efficient secretion of XWnt4, facilitating its role in Xenopus eye development PMID: 19223472
    3. Study shows that Wnt-4 acts through the Notch effector gene hrt1 by upregulating expression of wnt4; Wnt-4 then patterns the proximal pronephric anlagen to establish the specific compartments that span the medio-lateral axis. PMID: 19793883
  • 亚细胞定位：
    Secreted, extracellular space, extracellular matrix.
  • 蛋白家族：
    Wnt family
  • 组织特异性：
    Expressed in the brain and floor plate. In the developing pronephros, expressed in the proximal tubules and nephrostomes but absent from the pronephric duct.
  • 数据库链接：

    KEGG: xla:397706

    UniGene: Xl.952