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  4. Recombinant Xenopus laevis Forkhead box protein A2-A (foxa2-a)

Recombinant Xenopus laevis Forkhead box protein A2-A (foxa2-a)

  • 中文名称：
    有爪蟾蜍foxa2-a重组蛋白
  • 货号：
    CSB-YP849602XBE
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    有爪蟾蜍foxa2-a重组蛋白
  • 货号：
    CSB-EP849602XBE
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    有爪蟾蜍foxa2-a重组蛋白
  • 货号：
    CSB-EP849602XBE-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    有爪蟾蜍foxa2-a重组蛋白
  • 货号：
    CSB-BP849602XBE
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    有爪蟾蜍foxa2-a重组蛋白
  • 货号：
    CSB-MP849602XBE
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    foxa2-a
  • Uniprot No.：
  • 别名：
    foxa2-aForkhead box protein A2-A; FoxA2-A; FoxA2a; Fork head domain-related protein 3; xFD-3; Hepatocyte nuclear factor 3-beta homolog A; HNF-3-beta-A; HNF3-beta homolog A; HNF3-beta-A; xHNF3-beta-A; xbeta-1
  • 种属：
    Xenopus laevis (African clawed frog)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-434
  • 氨基酸序列
    MLGAVKMEGH EATDWSSYYG EAEAYSSVGN MNAGLSMNPM NTYMSMSAMR TSANMTASSM NMSYVNTGMS PSLTGMSPGT GAMTGMGTGV PSMASHLSPS MIPMSAQTTA MNALAPYTNI NSMSPIYGQS NINRSRDPKT YRRSYTHAKP PYSYISLITM AIQQSPNKML TLSEIYQWIM DLFPFYRQNQ QRWQNSIRHS LSFNDCFLKV PRSPDKPGKG SFWTLHPDSG NMFENGCYLR RQKRFKCEKK PSLREGGGKK LSEGASSVGS AANSSSESSV GNESPHSSSS PCQEQKRSLV DMKSSQGLSP KHATSPASQA QHLLSQHHSV LSHEAQSHLK PEHHYSFNHP FSINNLMSSE QQHHHHHHHN HHHHHKMDLK AYEQVMHYSS YGSPMAGSLA MSTVTNKSGL ESSPITSDTS YYQGGYSRPI MNSS
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Acts as a transcriptional activator during early development, limiting the extent of mesoderm formation in the gastrula. Binds to DNA via the target sequence 5'-GT[AC]AACA-3', with 5'-GTAAACA-3' being the preferred binding site.
  • 基因功能参考文献：
    1. Together SMAD3 and ZIC2 regulate FOXA2 transcription in cultured cells and Zic2 also controls the foxA2 expression during Xenopus development. These findings reveal a new mechanism of NODAL signal transduction in the mammalian node and provide the first molecular explanation of how ZIC2 loss-of-function precipitates Holoprosencephaly (HPE). PMID: 27466203
    2. HNF3beta target genes function to limit the extent of mesoderm formation in the Xenopus gastrula. PMID: 14697355
  • 亚细胞定位：
    Nucleus.
  • 组织特异性：
    At gastrula stage, expressed in both the anterior and posterior endoderm, with endodermal expression persisting into early tailbud stages. Expression is absent in gastrula stage ectoderm. During tailbud stages, expressed in the pharyngeal region, the neur
  • 数据库链接：

    KEGG: xla:100127318

    UniGene: Xl.40286