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  4. Recombinant Virulence-associated V antigen (lcrV)

Recombinant Virulence-associated V antigen (lcrV)

  • 货号：
    CSB-YP315209YAS
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP315209YAS-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP315209YAS
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP315209YAS
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    lcrV
  • Uniprot No.：
  • 别名：
    lcrV; icrV; YPCD1.31c; y5047; y0050; YP_pCD52Virulence-associated V antigen; Low calcium response locus protein V
  • 种属：
    Yersinia pestis
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-326
  • 氨基酸序列
    MIRAYEQNPQ HFIEDLEKVR VEQLTGHGSS VLEELVQLVK DKNIDISIKY DPRKDSEVFA NRVITDDIEL LKKILAYFLP EDAILKGGHY DNQLQNGIKR VKEFLESSPN TQWELRAFMA VMHFSLTADR IDDDILKVIV DSMNHHGDAR SKLREELAEL TAELKIYSVI QAEINKHLSS SGTINIHDKS INLMDKNLYG YTDEEIFKAS AEYKILEKMP QTTIQVDGSE KKIVSIKDFL GSENKRTGAL GNLKNSYSYN KDNNELSHFA TTCSDKSRPL NDLVSQKTTQ LSDITSRFNS AIEALNRFIQ KYDSVMQRLL DDTSGK
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Possibly involved in calcium regulation of YOP expression, which includes the export process.
  • 基因功能参考文献：
    1. findings show that LcrV, the cap protein of bacterial type III secretion needles, is modified by host glutathione and that this modification contributes to the high virulence of Y. pestis in mouse and rat models for bubonic plague; these data suggest that Y. pestis exploits glutathione in host tissues to activate a virulence strategy, thereby accelerating plague pathogenesis PMID: 28512097
    2. The crystal structure of LcrV is reported here without the triple mutation and with a different orientation. PMID: 23695558
    3. Our data indicate that the most abundant molecular species of Y. pestis LcrV do not efficiently activate TLR2-signaling and that TLR2-mediated immunomodulation is unlikely to play a significant role in plague. PMID: 17438030
  • 亚细胞定位：
    Secreted.
  • 数据库链接：

    KEGG: ype:YPCD1.31c