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  4. Recombinant Tropomodulin (unc-94)

Recombinant Tropomodulin (unc-94)

  • 货号：
    CSB-YP515310CXY
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP515310CXY
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP515310CXY-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP515310CXY
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP515310CXY
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    unc-94
  • Uniprot No.：
  • 别名：
    unc-94; tmd-1; C06A5.7; Tropomodulin; Tmod-like protein; cTmd1; Uncoordinated protein 94
  • 种属：
    Caenorhabditis elegans
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-392
  • 氨基酸序列
    MSQAKTDYYS EEKTFSAPSA NSQQGTQLPS KVYNKGLKDL EDNDIEGLLS SLSIDELEDL NNDFDPDNSM LPPSQRCRDQ TDKEPTGPYK RDNLLKFLED KAKTEKDWED VCPYTPGQKR GKVYDSDSGR NSEEPENGKM EMPIEIDLDD DEEELECALV TAPEKDLVDL AGILGMHNVL NQPQYYNALK GKTQDESTGT TFNGIMQSYV PRIVPDEPDN DTDVESCINR LREDDTDLKE VNINNMKRVS KERIRSLIEA ACNSKHIEKF SLANTAISDS EARGLIELIE TSPSLRVLNV ESNFLTPELL ARLLRSTLVT QSIVEFKADN QRQSVLGNQV EMDMMMAIEE NESLLRVGIS FASMEARHRV SEALERNYER VRLRRLGKDP NV
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Acts as the pointed end capping protein which maintains the length and dynamics of the actin filament. Blocks the elongation and depolymerization of the actin filaments at the pointed end.
  • 基因功能参考文献：
    1. The data support a model in which minus-end actin capping by UNC-94 promotes proper F-actin structure and contraction in the terminal web, yielding proper shape of the intestinal lumen. PMID: 24677443
    2. In vitro, UNC-94 acts in combination with HMP-1, leading to longer actin bundles than with HMP-1 alone. PMID: 22771044
    3. C-terminal part of tropomodulin protein 1, isoform A, from Caenorhabditis elegans was expressed in Escherichia coli and purified to homogeneity PMID: 12777789
    4. cTmd1 consists of AAs 196-392. The chain is well defined in the 2Fo-Fc map for the range 222-388. Much of the N-terminus, including AAs 196-221, is entirely disordered. The C-terminus of cTmd1 has 6 additional AAs. 4 of them (389-392) are disordered. PMID: 15211521
    5. study shows that the mutationally identified gene unc-94 corresponds with the sequence-predicted gene tmd-1 (C06A5.7), which encodes a tropomodulin PMID: 17976644

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  • 亚细胞定位：
    Cytoplasm, cytoskeleton.
  • 蛋白家族：
    Tropomodulin family
  • 数据库链接：

    KEGG: cel:CELE_C06A5.7

    STRING: 6239.C06A5.7b

    UniGene: Cel.17356