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  4. Recombinant Transcription factor unc-86 (unc-86)

Recombinant Transcription factor unc-86 (unc-86)

  • 中文名称：
    秀丽隐杆线虫unc-86重组蛋白
  • 货号：
    CSB-YP319563CXY
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    秀丽隐杆线虫unc-86重组蛋白
  • 货号：
    CSB-EP319563CXY
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    秀丽隐杆线虫unc-86重组蛋白
  • 货号：
    CSB-EP319563CXY-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    秀丽隐杆线虫unc-86重组蛋白
  • 货号：
    CSB-BP319563CXY
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    秀丽隐杆线虫unc-86重组蛋白
  • 货号：
    CSB-MP319563CXY
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    unc-86
  • Uniprot No.：
  • 别名：
    unc-86; C30A5.7; Transcription factor unc-86; Uncoordinated protein 86
  • 种属：
    Caenorhabditis elegans
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-467
  • 氨基酸序列
    MEKAHRFRLP FCSFFPVPLL VSVLIFHHSA PFLIQLFFPS PLFNPLLRPS KISRGSENGA CTSHSTLQRT RKIIQWELPK RGGDQDIGDP RPFRIHLSPP SFKVPLFSTD MQNTAPVPTT TTASKMQPFN NSLFGSFDDP ILNARAAQVA LADIDVKNVP QLTNPLMRPH DMFSYSNYFS GIHDTSAATN IYQGLPSSSE PFDASVVVPT SSDDQMTPLQ QVMAMQQSYG APPPFQYNMT HPFSTTSIAS SNNLARYPIA PPTSDMDTDP RQLETFAEHF KQRRIKLGVT QADVGKALAH LKMPGVGSLS QSTICRFESL TLSHNNMVAL KPILHSWLEK AEEAMKQKDT IGDINGILPN TDKKRKRTSI AAPEKRELEQ FFKQQPRPSG ERIASIADRL DLKKNVVRVW FCNQRQKQKR DFRSQFRARS AAAVMGPRVM PVLNGNNSNN NLKQGQTTYN GLPGFFD
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transcription factor required for correct cell fate determination and differentiation in diverse neuronal cell lineages where it plays a role in specifying the fate of daughter cells during cell divisions. Involved in sensory neuron production and function. Binds both alone and with mec-3 to the mec-3 promoter to initiate and maintain mec-3 expression which is required for sensory neuron differentiation. In addition, binds both alone and with mec-3 to the promoters of mec-4 and mec-7 which act to regulate sensory neuron function. Involved in determining the identity of the serotonergic NSM neurons and the cholinergic IL2 sensory and URA motor neurons. Promotes expression of the cfi-1 transcription factor in the URA and IL2 neurons which in turn activates normal URA and IL2 gene expression. Regulates expression of a number of genes in NSM neurons including bas-1, cat-1, dop-3, mgl-3, nlp-13, scd-2 and ptps-1. In the IL2 neurons, required for expression of cho-1, gcy-19, klp-6, lag-2, unc-5 and unc-17. Promotes expression of pkd-2 in the male-specific CEM head neurons. Required for dauer-specific branching of IL2Q neurons and nictation behavior. Controls both the timing and direction of axon outgrowth in HSN neurons. Plays a role in serotonin production by regulating expression of the tryptophan hydrolase tph-1 which catalyzes serotonin synthesis, in the AIM, NSM, HSN and RIH neurons. Involved in regulation of lin-11 expression in the AIZ interneurons, the major interneurons of the olfactory pathway, and is required for odortaxis behavior. Involved in neurite pruning between AIM neurons during larval development by regulating the expression of transcription factor mbr-1. Required for correct localization of unc-40.
  • 基因功能参考文献：
    1. the type of differentiation program that is controlled by ttx-3 in different neuron types is specified by a distinct set of collaborating transcription factors, including the POU homeobox gene unc-86 PMID: 24353061
    2. Data propose that unc-86(lf) HSN axons are misguided due to the temporal decoupling of axon initiation and ventral guidance responses. PMID: 21656875
    3. UNC-86 POU transcription factor modulates olfactory sensitivity PMID: 12883006
  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    POU transcription factor family, Class-4 subfamily
  • 组织特异性：
    Specific to neurons and neuroblasts. Expressed in CEM head neurons and in IL2, URA, URB, URX and URY neurons. Not expressed in olfactory sensory neurons but expressed in AIZ interneurons.
  • 数据库链接：

    KEGG: cel:CELE_C30A5.7

    STRING: 6239.C30A5.7b

    UniGene: Cel.24958